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ATG17 protein kinase regulatory subunit ATG17 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851142, updated on 18-Sep-2024

Summary

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Official Symbol
ATG17
Official Full Name
protein kinase regulatory subunit ATG17
Primary source
SGD:S000004415
Locus tag
YLR423C
See related
AllianceGenome:SGD:S000004415; FungiDB:YLR423C; VEuPathDB:YLR423C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
APG17
Summary
Enables SNARE binding activity; molecular adaptor activity; and protein kinase activator activity. Involved in several processes, including autophagosome organization; autophagy of nucleus; and positive regulation of autophagosome assembly. Located in phagophore assembly site and vacuole-isolation membrane contact site. Part of Atg1/ULK1 kinase complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ATG17 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (971917..973170, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene proteasome regulatory particle lid subunit RPN13 Neighboring gene Dck1p Neighboring gene mRNA splicing protein SPP382 Neighboring gene tRNA-Asn

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Autophagy induction under carbon starvation conditions is negatively regulated by carbon catabolite repression. Adachi A, et al. J Biol Chem, 2017 Dec 1. PMID 29042435, Free PMC Article
  2. Autophosphorylation within the Atg1 activation loop is required for both kinase activity and the induction of autophagy in Saccharomyces cerevisiae. Yeh YY, et al. Genetics, 2010 Jul. PMID 20439775, Free PMC Article
  3. Cis1/Atg31 is required for autophagosome formation in Saccharomyces cerevisiae. Kabeya Y, et al. Biochem Biophys Res Commun, 2007 May 4. PMID 17362880
  4. Using GBP Nanotrap to Restore Autophagy in the Rab5/Vps21 Mutant by Forcing Snf7 and Atg17 Interaction. Zhao M, et al. Methods Mol Biol, 2021. PMID 34453717
  5. Structural basis of starvation-induced assembly of the autophagy initiation complex. Fujioka Y, et al. Nat Struct Mol Biol, 2014 Jun. PMID 24793651

See all (127) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TOR-mediated Ypt1 phosphorylation regulates autophagy initiation complex assembly.
    Title: TOR-mediated Ypt1 phosphorylation regulates autophagy initiation complex assembly.
  2. Atg17 adopts multiple conformations in the absence of Atg31 and Atg29 suggests that the two smaller components play key roles in defining and maintaining the distinct curvature of the ternary complex
    Title: Structural characterization of the Saccharomyces cerevisiae autophagy regulatory complex Atg17-Atg31-Atg29.
  3. single-particle electron microscopy analysis of the Atg17-Atg31-Atg29 complex reveals an elongated structure with Atg29 located at the opposing ends.
    Title: Atg29 phosphorylation regulates coordination of the Atg17-Atg31-Atg29 complex with the Atg11 scaffold during autophagy initiation.
  4. The PAS scaffold proteins (Atg13 and Atg17) and phosphatidylinositol 3-kinase complex I were localized to a position at the junction between the IM and the vacuolar membrane, termed the vacuole-IM contact site (VICS).
    Title: Fine mapping of autophagy-related proteins during autophagosome formation in Saccharomyces cerevisiae.
  5. in autophagy-inducing condition, Atg9 is recruited to the pre-autophagosomal structure in a manner dependent on Atg17
    Title: Atg17 recruits Atg9 to organize the pre-autophagosomal structure.
  6. Atg17-Atg29-Atg31 ternary complex acts as a functional unit for autophagosome formation.
    Title: Characterization of the Atg17-Atg29-Atg31 complex specifically required for starvation-induced autophagy in Saccharomyces cerevisiae.
  7. Atg17 regulates the magnitude of the autophagic response
    Title: Atg17 regulates the magnitude of the autophagic response.
  8. Atg17-Atg13 complex formation plays an important role in normal autophagosome formation via binding to and activating the Atg1 kinase.
    Title: Atg17 functions in cooperation with Atg1 and Atg13 in yeast autophagy.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables SNARE binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular adaptor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagy of mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in autophagy of peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to nitrogen starvation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pexophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in piecemeal microautophagy of the nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in piecemeal microautophagy of the nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of autophagosome assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of autophagosome size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to phagophore assembly site IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of Atg1/ULK1 kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Atg1/ULK1 kinase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Atg1/ULK1 kinase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
is_active_in phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagophore assembly site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagophore assembly site membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole-isolation membrane contact site IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein kinase regulatory subunit ATG17
NP_013527.3
  • Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity; human ortholog RB1CC1/FIP200 interacts with p53, which inhibits autophagy in human cells

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    971917..973170 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182311.3 → NP_013527.3  TPA: protein kinase regulatory subunit ATG17 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013527.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZ59, Q06410
    UniProtKB/TrEMBL
    B3RHT3, B5VNV8, C7GXM4, C8ZE31, N1NZW4
    Conserved Domains (1) summary
    pfam04108
    Location:8 → 404
    APG17; Autophagy protein Apg17
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06410.1

Gene LinkOut

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