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GRX8 glutathione-disulfide reductase GRX8 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851079, updated on 2-Nov-2024

Summary

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Official Symbol
GRX8
Official Full Name
glutathione-disulfide reductase GRX8
Primary source
SGD:S000004356
Locus tag
YLR364W
See related
AllianceGenome:SGD:S000004356; FungiDB:YLR364W; VEuPathDB:YLR364W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables glutathione-disulfide reductase (NADPH) activity. Predicted to be involved in cellular oxidant detoxification. Located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See GRX8 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (854062..854391)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Nmd4p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ribosomal 40S subunit protein S22B Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. catalytic mechanism of yeast grx8
    Title: Structure-guided activity enhancement and catalytic mechanism of yeast grx8.
  2. ScGrx8 has several novel structural and mechanistic features expanding the subclasses of glutaredoxins.
    Title: Biochemical characterization of dithiol glutaredoxin 8 from Saccharomyces cerevisiae: the catalytic redox mechanism redux.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables glutathione-disulfide reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glutathione-disulfide reductase GRX8
NP_013468.3
  • Glutaredoxin that employs a dithiol mechanism of catalysis; monomeric; activity is low and null mutation does not affect sensitivity to oxidative stress; GFP-fusion protein localizes to the cytoplasm; expression strongly induced by arsenic

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    854062..854391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182253.3 → NP_013468.3  TPA: glutathione-disulfide reductase GRX8 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013468.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZ03, Q05926
    UniProtKB/TrEMBL
    A7A1P3, B3RHN3, C7GRW0, C8ZDX3, G2WJI3, N1P791
    Conserved Domains (1) summary
    COG0695
    Location:21 → 99
    GrxC; Glutaredoxin [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05926.1

Gene LinkOut

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