ADE13 adenylosuccinase ADE13 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ADE13
Official Full Name: adenylosuccinase ADE13
Primary source: SGD:S000004351
Locus tag: YLR359W
See related: AllianceGenome:SGD:S000004351; FungiDB:YLR359W; VEuPathDB:YLR359W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: BRA1; BRA8
Summary: Enables N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity. Involved in 'de novo' IMP biosynthetic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in adenylosuccinase lyase deficiency. Orthologous to human ADSL (adenylosuccinate lyase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ADE13 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (844282..845730)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

genes ADE12, ADE13, AAH1, and HAM1 controlling processes of purine utilization and interconversion in yeast make the greatest contribution to the system of protection against the toxic and mutagenic action of the examined analogs.
Title: [Genetic control of metabolism of mutagenic purine base analogs 6-hydroxylaminopurine and 2-amino-6-hydroxylaminopurine in yeast Saccharomyces cerevisiae].

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity	IBA Inferred from Biological aspect of Ancestor more info
enables (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity	IEA Inferred from Electronic Annotation more info
enables N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity	IBA Inferred from Biological aspect of Ancestor more info
enables N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity	IEA Inferred from Electronic Annotation more info
enables N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables lyase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' AMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in 'de novo' AMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 'de novo' IMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 'de novo' IMP biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in 'de novo' IMP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in purine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleotide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in purine ribonucleoside monophosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in purine ribonucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: adenylosuccinase ADE13

NP_013463.1

EC 4.3.2.2

Adenylosuccinate lyase; catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency; human ADSL can complement yeast ADE13 null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

844282..845730

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182248.1 → NP_013463.1 TPA: adenylosuccinase ADE13 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013463.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VYZ6, Q05911

UniProtKB/TrEMBL

A7A1N6, B3RHM7, C7GRY3, C8ZDW6, G2WJH6, N1NZP4

Conserved Domains (1) summary

cd03302
Location:11 → 449

Adenylsuccinate_lyase_2; Adenylsuccinate lyase (ASL)_subgroup 2