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BUD8 Bud8p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851067, updated on 2-Nov-2024

Summary

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Official Symbol
BUD8
Official Full Name
Bud8p
Primary source
SGD:S000004345
Locus tag
YLR353W
See related
AllianceGenome:SGD:S000004345; FungiDB:YLR353W; VEuPathDB:YLR353W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in cellular bud site selection and pseudohyphal growth. Located in cellular bud tip; incipient cellular bud site; and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See BUD8 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (834352..836163)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene putative hydrolase Neighboring gene Lug1p Neighboring gene sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase TAL1 Neighboring gene ketol-acid reductoisomerase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Up-regulation of the Cdc42 GTPase limits the replicative life span of budding yeast. Kang PJ, et al. Mol Biol Cell, 2022 Apr 1. PMID 35044837, Free PMC Article
  2. The role of cell cycle-regulated expression in the localization of spatial landmark proteins in yeast. Schenkman LR, et al. J Cell Biol, 2002 Mar 4. PMID 11877459, Free PMC Article
  3. Bud8p and Bud9p, proteins that may mark the sites for bipolar budding in yeast. Harkins HA, et al. Mol Biol Cell, 2001 Aug. PMID 11514631, Free PMC Article
  4. Asymmetrically localized Bud8p and Bud9p proteins control yeast cell polarity and development. Taheri N, et al. EMBO J, 2000 Dec 15. PMID 11118203, Free PMC Article
  5. Mitotic and pheromone-specific intrinsic polarization cues interfere with gradient sensing in Saccharomyces cerevisiae. Vasen G, et al. Proc Natl Acad Sci U S A, 2020 Mar 24. PMID 32152126, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These observations suggest that the interaction of Rax2p with Bud8p and Bud9p may contribute to the translocation of bipolar landmarks to the correct sites.
    Title: Subcellular localization of the interaction of bipolar landmarks Bud8p and Bud9p with Rax2p in Saccharomyces cerevisiae diploid cells.
  2. Bud8p and Bud9p carry distinct domains for delivery of the proteins to the cell poles, for interaction with the general budding machinery and for association with other cortical tag proteins.
    Title: Distinct domains of yeast cortical tag proteins Bud8p and Bud9p confer polar localization and functionality.
  3. Rax1p and Rax2p interact closely with each other and with Bud8p and Bud9p in the establishment and/or maintenance of the cortical landmarks for bipolar budding
    Title: Interactions among Rax1p, Rax2p, Bud8p, and Bud9p in marking cortical sites for bipolar bud-site selection in yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cellular bud site selection IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pseudohyphal growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cellular bud tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in incipient cellular bud site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Bud8p
NP_013457.1
  • Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole; BUD8 has a paralog, BUD9, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    834352..836163
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182242.1 → NP_013457.1  TPA: Bud8p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013457.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYZ1, P41698, Q06482
    UniProtKB/TrEMBL
    B3RHM2, C8ZDW0, G2WJH1, N1P1P2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41698.2

Gene LinkOut

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