U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ACO1 aconitate hydratase ACO1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851013, updated on 28-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
ACO1
Official Full Name
aconitate hydratase ACO1
Primary source
SGD:S000004295
Locus tag
YLR304C
See related
AllianceGenome:SGD:S000004295; FungiDB:YLR304C; VEuPathDB:YLR304C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GLU1
Summary
Enables aconitate hydratase activity and nucleic acid binding activity. Involved in mitochondrial genome maintenance and tricarboxylic acid cycle. Located in cytosol and mitochondrial nucleoid. Used to study central nervous system disease; neurodegenerative disease; optic atrophy 9; and optic nerve disease. Human ortholog(s) of this gene implicated in infantile cerebellar-retinal degeneration and optic atrophy 9. Orthologous to human ACO2 (aconitase 2). [provided by Alliance of Genome Resources, Oct 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ACO1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (735212..737548, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase MET17 Neighboring gene tRNA-Ile Neighboring gene 1-phosphatidylinositol 4-kinase STT4 Neighboring gene NEDD8-conjugating protein UBC12

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Molecular cloning of the yeast mitochondrial aconitase gene (ACO1) and evidence of a synergistic regulation of expression by glucose plus glutamate. Gangloff SP, et al. Mol Cell Biol, 1990 Jul. PMID 1972545, Free PMC Article
  2. GroEL/GroES-mediated folding of a protein too large to be encapsulated. Chaudhuri TK, et al. Cell, 2001 Oct 19. PMID 11672530
  3. The aconitase C-terminal domain is an independent dual targeting element. Ben-Menachem R, et al. J Mol Biol, 2011 Jun 3. PMID 21440554
  4. Selective inhibition of the citrate-to-isocitrate reaction of cytosolic aconitase by phosphomimetic mutation of serine-711. Pitula JS, et al. Proc Natl Acad Sci U S A, 2004 Jul 27. PMID 15263083, Free PMC Article
  5. Quantitation of (a)symmetric inheritance of functional and of oxidatively damaged mitochondrial aconitase in the cell division of old yeast mother cells. Klinger H, et al. Exp Gerontol, 2010 Aug. PMID 20382214

See all (151) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Yeast ACO1 mitochondrial import is modulated by interactions of its C and N terminal domains and SSA1/SSA2.
    Title: Yeast aconitase mitochondrial import is modulated by interactions of its C and N terminal domains and Ssa1/2 (Hsp70).
  2. Lack of the ACO1 gene results in increased zinc tolerance.
    Title: On the molecular relationships between high-zinc tolerance and aconitase (Aco1) in Saccharomyces cerevisiae.
  3. mitochondria are opportunistic organelles that seize proteins, such as metabolic enzymes, for construction of the nucleoid, an mitochondrial DNA maintenance/segregation apparatus
    Title: Yeast aconitase binds and provides metabolically coupled protection to mitochondrial DNA.
  4. essential for mtDNA maintenance independent of its catalytic activity; may integrate metabolic signals and mtDNA maintenance
    Title: Aconitase couples metabolic regulation to mitochondrial DNA maintenance.
  5. Yeast aconitase isoenzymes distribute between two distinct subcellular compartments and participate in two separate metabolic pathways: the glyoxylate shunt in the cytosol and the tricarboxylic acid cycle in mitochondria.
    Title: Yeast aconitase in two locations and two metabolic pathways: seeing small amounts is believing.
  6. frataxin is an iron chaperone protein that protects the aconitase [4Fe-4S]2+ cluster from disassembly and promotes enzyme reactivation
    Title: Frataxin acts as an iron chaperone protein to modulate mitochondrial aconitase activity.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables aconitate hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aconitate hydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aconitate hydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables aconitate hydratase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial genome maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
aconitate hydratase ACO1
NP_013407.1
  • Aconitase; required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy; mutation in human homolog ACO2 is associated with dominant optic nerve atrophy; human homolog ACO2 can complement yeast null mutant

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    735212..737548 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182192.1 → NP_013407.1  TPA: aconitate hydratase ACO1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013407.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYU7, P19414
    UniProtKB/TrEMBL
    A7A1I8, B3RHI2, C7GUC7, C8ZDR7, G2WJC5, N1P1J9
    Conserved Domains (1) summary
    TIGR01340
    Location:41 → 772
    aconitase_mito; aconitate hydratase, mitochondrial
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P19414.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.