BNA5 kynureninase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: BNA5
Official Full Name: kynureninase
Primary source: SGD:S000004221
Locus tag: YLR231C
See related: AllianceGenome:SGD:S000004221; FungiDB:YLR231C; VEuPathDB:YLR231C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables kynureninase activity. Involved in 'de novo' NAD biosynthetic process from tryptophan. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in hydroxykynureninuria. Orthologous to human KYNU (kynureninase). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables kynureninase activity	IBA Inferred from Biological aspect of Ancestor more info
enables kynureninase activity	IEA Inferred from Electronic Annotation more info
enables kynureninase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' NAD biosynthetic process from tryptophan	IEA Inferred from Electronic Annotation more info
involved_in 'de novo' NAD biosynthetic process from tryptophan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in L-kynurenine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in NAD biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in anthranilate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in anthranilate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in pyridine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in quinolinate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in tryptophan catabolic process	IEA Inferred from Electronic Annotation more info
involved_in tryptophan catabolic process to kynurenine	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info