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RPS31 ubiquitin-ribosomal 40S subunit protein S31 fusion protein [ Saccharomyces cerevisiae S288C ]

Gene ID: 850864, updated on 28-Oct-2024

Summary

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Official Symbol
RPS31
Official Full Name
ubiquitin-ribosomal 40S subunit protein S31 fusion protein
Primary source
SGD:S000004157
Locus tag
YLR167W
See related
AllianceGenome:SGD:S000004157; FungiDB:YLR167W; VEuPathDB:YLR167W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RPS37; UBI3
Summary
Enables protein tag activity. Involved in maintenance of translational fidelity; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S); and ribosomal small subunit assembly. Located in cytoplasm. Part of cytosolic small ribosomal subunit. Orthologous to human RPS27A (ribosomal protein S27a) and RPS27AP5 (ribosomal protein S27a pseudogene 5). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See RPS31 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (498947..499405)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene pseudouridine synthase PUS5 Neighboring gene exocyst subunit SEC10 Neighboring gene Ups2p Neighboring gene Aps1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A human ubiquitin carboxyl extension protein functions in yeast. Monia BP, et al. J Biol Chem, 1990 Nov 5. PMID 2229081
  2. Linear ubiquitin fusion to Rps31 and its subsequent cleavage are required for the efficient production and functional integrity of 40S ribosomal subunits. Lacombe T, et al. Mol Microbiol, 2009 Apr. PMID 19210616
  3. A ribosomal protein is required for translational regulation of GCN4 mRNA. Evidence for involvement of the ribosome in eIF2 recycling. Mueller PP, et al. J Biol Chem, 1998 Dec 4. PMID 9830035
  4. Dissecting the Specificity of Adenosyl Sulfamate Inhibitors Targeting the Ubiquitin-Activating Enzyme. Misra M, et al. Structure, 2017 Jul 5. PMID 28578874
  5. The eukaryote-specific N-terminal extension of ribosomal protein S31 contributes to the assembly and function of 40S ribosomal subunits. Fernández-Pevida A, et al. Nucleic Acids Res, 2016 Sep 19. PMID 27422873, Free PMC Article

See all (121) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interaction between Gtr2p and ribosomal Rps31p affects the incorporation of Rps31p into ribosomes of Saccharomyces cerevisiae.
    Title: Interaction between Gtr2p and ribosomal Rps31p affects the incorporation of Rps31p into ribosomes of Saccharomyces cerevisiae.
  2. Deletion of the ubiquitin moiety from UBI3 led to a decrease in 40S ribosomal subunits and to the incorporation of the 20S pre-rRNA into polyribosomes.
    Title: Linear ubiquitin fusion to Rps31 and its subsequent cleavage are required for the efficient production and functional integrity of 40S ribosomal subunits.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein tag activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tag activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables structural constituent of ribosome IC
Inferred by Curator
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in maintenance of translational fidelity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in modification-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal small subunit assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ubiquitin-ribosomal 40S subunit protein S31 fusion protein
NP_013268.1
  • Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B; homologous to mammalian ribosomal protein S27A, no bacterial homolog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    498947..499405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182054.1 → NP_013268.1  TPA: ubiquitin-ribosomal 40S subunit protein S31 fusion protein [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013268.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYH3, P05759, P14800
    UniProtKB/TrEMBL
    A7A160, B3RH62, C7GIV9, C8ZDE0, G2WJ02, N1P195
    Conserved Domains (2) summary
    cd01803
    Location:1 → 76
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    pfam01599
    Location:103 → 146
    Ribosomal_S27; Ribosomal protein S27a
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P05759.3

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