KIN2 serine/threonine protein kinase KIN2 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: KIN2
Official Full Name: serine/threonine protein kinase KIN2
Primary source: SGD:S000004086
Locus tag: YLR096W
See related: AllianceGenome:SGD:S000004086; FungiDB:YLR096W; VEuPathDB:YLR096W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables protein serine/threonine kinase activity. Involved in positive regulation of IRE1-mediated unfolded protein response and positive regulation of exocytosis. Located in cellular bud neck; cellular bud tip; and plasma membrane. Human ortholog(s) of this gene implicated in anencephaly; developmental and epileptic encephalopathy 30; and uterine fibroid. Orthologous to several human genes including NUAK1 (NUAK family kinase 1); NUAK2 (NUAK family kinase 2); and SIK3 (SIK family kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Phosphorylation of Pal2 by the protein kinases Kin1 and Kin2 modulates HAC1 mRNA splicing in the unfolded protein response in yeast.
Title: Phosphorylation of Pal2 by the protein kinases Kin1 and Kin2 modulates HAC1 mRNA splicing in the unfolded protein response in yeast.
Recognition of phosphorylated substrates by Kin1/Kin2 was mediated by a patch of basic residues located in the region of the kinase alphaC helix.
Title: Substrate priming enhances phosphorylation by the budding yeast kinases Kin1 and Kin2.
Overexpression of Kin2 affects septin organization and cell wall.
Title: Kin2, the Budding Yeast Ortholog of Animal MARK/PAR-1 Kinases, Localizes to the Sites of Polarized Growth and May Regulate Septin Organization and the Cell Wall.
Kin2 has a role in regulating HAC1 mRNA translocation, splicing, and translation
Title: A novel role for protein kinase Kin2 in regulating HAC1 mRNA translocation, splicing, and translation.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	HDA more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of IRE1-mediated unfolded protein response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of exocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of exocytosis	IPI Inferred from Physical Interaction more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cellular bud neck	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud tip	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IPI Inferred from Physical Interaction more info	PubMed

NP_013197.1

S/T protein kinase; regulates polarized exocytosis and the Ire1p-mediated UPR; regulates HAC1 mRNA translocation, splicing and translation with KIN1 during ER stress; direct phosphorylation of Sec9p (S190) is enhanced by prior substrate priming (S192); localizes to the cytoplasmic face of the PM and sites of polarized growth; may regulate septin and cell wall organization; activation loop phosphorylation (T281) required for full kinase activity; orthologous to MARK/PAR-1, AMPK family members

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The following sections contain reference sequences that belong to a specific genome build. Explain