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SPC3 signal peptidase complex subunit SPC3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850755, updated on 28-Oct-2024

Summary

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Official Symbol
SPC3
Official Full Name
signal peptidase complex subunit SPC3
Primary source
SGD:S000004056
Locus tag
YLR066W
See related
AllianceGenome:SGD:S000004056; FungiDB:YLR066W; VEuPathDB:YLR066W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in protein targeting to ER and signal peptide processing. Located in endoplasmic reticulum. Part of signal peptidase complex. Orthologous to human SPCS3 (signal peptidase complex subunit 3). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See SPC3 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (267169..267723)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Per33p Neighboring gene Snd2p Neighboring gene Pet309p Neighboring gene Fyv7p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The yeast SPC22/23 homolog Spc3p is essential for signal peptidase activity. Meyer HA, et al. J Biol Chem, 1997 May 16. PMID 9148931
  2. The catalytic mechanism of endoplasmic reticulum signal peptidase appears to be distinct from most eubacterial signal peptidases. VanValkenburgh C, et al. J Biol Chem, 1999 Apr 23. PMID 10206957
  3. Cotranslational Targeting and Posttranslational Translocation can Cooperate in Spc3 Topogenesis. Jung SJ, et al. J Mol Biol, 2021 Sep 3. PMID 34153287
  4. Characterization of Candida albicans orthologue of the Saccharomyces cerevisiae signal-peptidase-subunit encoding gene SPC3. De La Rosa JM, et al. Yeast, 2004 Jul 30. PMID 15300682
  5. Yeast signal peptidase contains a glycoprotein and the Sec11 gene product. YaDeau JT, et al. Proc Natl Acad Sci U S A, 1991 Jan 15. PMID 1846444, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein targeting to ER IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to ER IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal peptide processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal peptide processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal peptide processing IEA
Inferred from Electronic Annotation
more info
  
involved_in signal peptide processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of signal peptidase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of signal peptidase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of signal peptidase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
signal peptidase complex subunit SPC3
NP_013167.1
  • Subunit of signal peptidase complex; complex catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23; other members of the complex are Spc1p, Spc2p, and Sec11p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    267169..267723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181953.1 → NP_013167.1  TPA: signal peptidase complex subunit SPC3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013167.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VY67, Q12133
    UniProtKB/TrEMBL
    A7A0X1, B3LT36, B5VMZ8, C7GQP1, C8ZD38, G2WIQ8, N1P108
    Conserved Domains (1) summary
    pfam04573
    Location:4 → 177
    SPC22; Signal peptidase subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12133.1

Gene LinkOut

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