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EMA19 Ema19p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850739, updated on 18-Sep-2024

Summary

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Official Symbol
EMA19
Official Full Name
Ema19p
Primary source
SGD:S000004040
Locus tag
YLR050C
See related
AllianceGenome:SGD:S000004040; FungiDB:YLR050C; VEuPathDB:YLR050C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Acts upstream of or within protein targeting to mitochondrion. Located in endoplasmic reticulum. Orthologous to human TMEM97 (transmembrane protein 97). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See EMA19 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (245587..246072, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S0B Neighboring gene Mlo50p Neighboring gene Fcf2p Neighboring gene Ies3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The ER protein Ema19 facilitates the degradation of nonimported mitochondrial precursor proteins. Laborenz J, et al. Mol Biol Cell, 2021 Apr 15. PMID 33596095, Free PMC Article
  2. An ER surface retrieval pathway safeguards the import of mitochondrial membrane proteins in yeast. Hansen KG, et al. Science, 2018 Sep 14. PMID 30213914
  3. Mapping the functional yeast ABC transporter interactome. Snider J, et al. Nat Chem Biol, 2013 Sep. PMID 23831759, Free PMC Article
  4. Functional profiling of the Saccharomyces cerevisiae genome. Giaever G, et al. Nature, 2002 Jul 25. PMID 12140549
  5. The yeast Ess1 prolyl isomerase controls Swi6 and Whi5 nuclear localization. Atencio D, et al. G3 (Bethesda), 2014 Mar 20. PMID 24470217, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The ER protein Ema19 facilitates the degradation of nonimported mitochondrial precursor proteins.
    Title: The ER protein Ema19 facilitates the degradation of nonimported mitochondrial precursor proteins.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein targeting to mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ema19p
NP_013151.1
  • Integral ER membrane protein involved in protein sorting; component of ER-SURF, a pathway involved in retrieving mitochondrial membrane protein precursors and rerouting them to the mitochondrial translocation system; promotes the proteolytic degradation of non-productive mitochondrial precursor proteins suggesting involvement in quality control during protein import; GFP-fusion protein localizes to the ER; member of a conserved family of ER proteins including human homolog TMEM97

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    245587..246072 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181937.1 → NP_013151.1  TPA: Ema19p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013151.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VY52, Q12155
    UniProtKB/TrEMBL
    B3LT21, B5VMY5, C7GQM8, C8ZD22, G2WIP3, N1P6C6
    Conserved Domains (1) summary
    pfam10914
    Location:10 → 160
    DUF2781; Protein of unknown function (DUF2781)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12155.1

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