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CAK1 cyclin-dependent protein kinase-activating kinase CAK1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850515, updated on 18-Sep-2024

Summary

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Official Symbol
CAK1
Official Full Name
cyclin-dependent protein kinase-activating kinase CAK1
Primary source
SGD:S000001865
Locus tag
YFL029C
See related
AllianceGenome:SGD:S000001865; FungiDB:YFL029C; VEuPathDB:YFL029C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CIV1
Summary
Enables cyclin-dependent protein kinase activating kinase activity. Involved in several processes, including G2/M transition of mitotic cell cycle; negative regulation of transcription initiation from RNA polymerase II promoter; and protein phosphorylation. Located in cytoplasm. Used to study cystinosis; encephalitis; and intellectual disability. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See CAK1 in Genome Data Viewer
Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (78055..79161, complement)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene transcription factor HAC1 Neighboring gene alanine--glyoxylate transaminase Neighboring gene putative ATP-binding cassette family ATPase CAF16 Neighboring gene GTPase-activating protein GYP8

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Potential roles for autophosphorylation, kinase activity, and abundance of a CDK-activating kinase (Ee;CDKF;1) during growth in leafy spurge. Chao WS, et al. Plant Mol Biol, 2007 Feb. PMID 17063377
  2. Kinetic analysis of the cyclin-dependent kinase-activating kinase (Cak1p) from budding yeast. Enke DA, et al. J Biol Chem, 2000 Oct 27. PMID 10934199
  3. The effects of changing the site of activating phosphorylation in CDK2 from threonine to serine. Kaldis P, et al. J Biol Chem, 2000 Oct 20. PMID 10931829
  4. The CDK-activating kinase (Cak1p) from budding yeast has an unusual ATP-binding pocket. Enke DA, et al. J Biol Chem, 1999 Jan 22. PMID 9890950
  5. Human and yeast cdk-activating kinases (CAKs) display distinct substrate specificities. Kaldis P, et al. Mol Biol Cell, 1998 Sep. PMID 9725911, Free PMC Article

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. unusual stability of this Cak1:Cdc37 association may partly reflect unique structural features of the fungal Cak1
    Title: Cdc37 engages in stable, S14A mutation-reinforced association with the most atypical member of the yeast kinome, Cdk-activating kinase (Cak1).
  2. While Cak1 is constitutively active and expressed, dividing cells tightly regulate Cak1 protein levels to ensure presence of adequate levels of Cdc28 CDK activity.
    Title: A phosphorylation-independent role for the yeast cyclin-dependent kinase activating kinase Cak1.
  3. Hyperpolarized growth of Saccharomyces cerevisiae cak1P212S and cla4 mutants weakens cell walls and renders cells dependent on chitin synthase 3.
    Title: Hyperpolarized growth of Saccharomyces cerevisiae cak1P212S and cla4 mutants weakens cell walls and renders cells dependent on chitin synthase 3.
  4. Ctk1 phosphorylation on Thr-338 is carried out by Cak1 and is required for normal gene transcription during the transition into stationary phase
    Title: Phosphorylation by Cak1 regulates the C-terminal domain kinase Ctk1 in Saccharomyces cerevisiae.
  5. the interactions linking Cak1 with the PAF1 complex and with Ssu72 are not direct but mediated via Ctk1 and Bur1
    Title: Kinase Cak1 functionally interacts with the PAF1 complex and phosphatase Ssu72 via kinases Ctk1 and Bur1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cyclin-dependent protein kinase activating kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cyclin-dependent protein kinase activating kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription initiation by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cyclin-dependent protein kinase-activating kinase CAK1
NP_116624.1
  • Cyclin-dependent kinase-activating kinase; required for passage through the cell cycle; phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases; required for premeiotic DNA synthesis, expression of early and middle sporulation specific genes and direct phosphorylation of the Smk1p MAPK to regulate spore morphogenesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    78055..79161 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179937.1 → NP_116624.1  TPA: cyclin-dependent protein kinase-activating kinase CAK1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116624.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTK1, P43568
    UniProtKB/TrEMBL
    A7A210, C7GY82, G2WDB2, N1P4W8
    Conserved Domains (1) summary
    cl21453
    Location:13 → 234
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43568.1

Gene LinkOut

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