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MATALPHA2 homeodomain mating type protein alpha2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850406, updated on 2-Nov-2024

Summary

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Official Symbol
MATALPHA2
Official Full Name
homeodomain mating type protein alpha2
Primary source
SGD:S000000635
Locus tag
YCR039C
See related
AllianceGenome:SGD:S000000635; FungiDB:YCR039C; VEuPathDB:YCR039C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ALPHA2
Summary
Enables DNA binding activity, bending; DNA-binding transcription repressor activity, RNA polymerase II-specific; and sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MATALPHA2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (199546..200178, complement)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene putative ribokinase Neighboring gene SPX domain-containing inorganic phosphate transporter Neighboring gene Ras family guanine nucleotide exchange factor BUD5 Neighboring gene transcriptional co-activator mating type protein alpha Neighboring gene uncharacterized protein Neighboring gene Taf2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Chromatin structure mapping in Saccharomyces cerevisiae in vivo with DNase I. Wang X, et al. Nucleic Acids Res, 2001 May 1. PMID 11328878, Free PMC Article
  2. Targeting of E. coli beta-galactosidase to the nucleus in yeast. Hall MN, et al. Cell, 1984 Apr. PMID 6323016
  3. Corepressor-directed preacetylation of histone H3 in promoter chromatin primes rapid transcriptional switching of cell-type-specific genes in yeast. Desimone AM, et al. Mol Cell Biol, 2010 Jul. PMID 20439496, Free PMC Article
  4. Specific residues in the Pbx homeodomain differentially modulate the DNA-binding activity of Hox and Engrailed proteins. Peltenburg LT, et al. Development, 1997 Mar. PMID 9056783
  5. Analysis of nucleo-cytoplasmic transport in a thermosensitive mutant of nuclear pore protein NSP1. Nehrbass U, et al. Eur J Cell Biol, 1993 Oct. PMID 8269967

See all (120) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MATalpha2 (alpha2) mutants with impaired DNA binding become inaccessible to the Slx5/Slx8 pathway but are still rapidly degraded through efficient shunting to the Doa10 pathway.
    Title: DNA binding by the MATα2 transcription factor controls its access to alternative ubiquitin-modification pathways.
  2. Authors propose that competitive binding to MATalpha2 by the ubiquitylation machinery and alpha2 cofactors is balanced so that alpha2 can function in transcription repression yet be short lived enough to allow cell-type switching.
    Title: STUbL-mediated degradation of the transcription factor MATα2 requires degradation elements that coincide with corepressor binding sites.
  3. Analysis of MATalpha2 binding sites on the HO promotor that mediate repression of the HO gene.
    Title: Repression of the yeast HO gene by the MATalpha2 and MATa1 homeodomain proteins.
  4. Matalpha2 corepressors Tup1 and Ssn6 modify the in vivo degradation rate of Matalpha2.
    Title: The short-lived Matalpha2 transcriptional repressor is protected from degradation in vivo by interactions with its corepressors Tup1 and Ssn6.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding, bending IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
homeodomain mating type protein alpha2
NP_009868.3
  • Homeobox-domain protein; with Mcm1p, represses a-specific genes in haploids; acts with A1p to repress transcription of haploid-specific genes in diploids; one of two genes encoded by the MATalpha mating type cassette

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    199546..200178 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178753.1 → NP_009868.3  TPA: homeodomain mating type protein alpha2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009868.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQV2, P01367, P01368, P0CY08, P0CY09, Q6B2C0
    UniProtKB/TrEMBL
    A6ZTM1, B3LU20, C8Z424, G2WA57
    Conserved Domains (1) summary
    smart00389
    Location:135 → 188
    HOX; Homeodomain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CY08.1
P0CY09.1

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials