YCP4 flavodoxin-like fold family protein [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: YCP4
Official Full Name: flavodoxin-like fold family protein
Primary source: SGD:S000000597
Locus tag: YCR004C
See related: AllianceGenome:SGD:S000000597; FungiDB:YCR004C; VEuPathDB:YCR004C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable FMN binding activity and NAD(P)H dehydrogenase (quinone) activity. Acts upstream of or within positive regulation of ferroptosis. Located in eisosome and plasma membrane. Is active in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome III - NC_001135.5 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Disruption of YCP4 enhances freeze-thaw tolerance in Saccharomyces cerevisiae.
Title: Disruption of YCP4 enhances freeze-thaw tolerance in Saccharomyces cerevisiae.
YCP4 and RFS1 have a clear role in the regulation of metabolism at the late stages of growth.
Title: The Saccharomyces cerevisiae flavodoxin-like proteins Ycp4 and Rfs1 play a role in stress response and in the regulation of genes related to metabolism.
These results suggest that the reduction of oxidized hPTEN is regulated by Grx5 and Ycp4.
Title: Redox regulation of the tumor suppressor PTEN by glutaredoxin 5 and Ycp4.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables FMN binding	IEA Inferred from Electronic Annotation more info
enables NAD(P)H dehydrogenase (quinone) activity	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of ferroptosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in eisosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

NP_009930.1

hypothetical protein; has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

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The following sections contain reference sequences that belong to a specific genome build. Explain