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BUD3 Bud3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850345, updated on 1-Aug-2024

Summary

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Gene symbol
BUD3
Gene description
Bud3p
Primary source
FungiDB:YCL014W
Locus tag
YCL014W
See related
SGD:S000000520; AllianceGenome:SGD:S000000520; VEuPathDB:YCL014W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YCL012W
Summary
Enables guanyl-nucleotide exchange factor activity. Involved in axial cellular bud site selection; cytogamy; and positive regulation of GTPase activity. Located in cellular bud neck contractile ring. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See BUD3 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (96281..101191)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene cysteine desulfurase Neighboring gene Dcc1p Neighboring gene uncharacterized protein Neighboring gene single-stranded telomeric DNA-binding/mRNA-binding protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of an amphipathic helix important for the formation of ectopic septin spirals and axial budding in yeast axial landmark protein Bud3p. Guo J, et al. PLoS One, 2011 Mar 8. PMID 21408200, Free PMC Article
  2. Critical Roles of a RhoGEF-Anillin Module in Septin Architectural Remodeling during Cytokinesis. Chen X, et al. Curr Biol, 2020 Apr 20. PMID 32197082, Free PMC Article
  3. Cell cycle programs of gene expression control morphogenetic protein localization. Lord M, et al. J Cell Biol, 2000 Dec 25. PMID 11134078, Free PMC Article
  4. Coupling of septins to the axial landmark by Bud4 in budding yeast. Kang PJ, et al. J Cell Sci, 2013 Mar 1. PMID 23345395, Free PMC Article
  5. Role of Bud3p in producing the axial budding pattern of yeast. Chant J, et al. J Cell Biol, 1995 May. PMID 7730410, Free PMC Article

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Critical Roles of a RhoGEF-Anillin Module in Septin Architectural Remodeling during Cytokinesis.
    Title: Critical Roles of a RhoGEF-Anillin Module in Septin Architectural Remodeling during Cytokinesis.
  2. Cell polarization in Saccharomyces cerevisiae, to a proper growth site, requires activation of Cdc42 by Bud3.
    Title: Bud3 activates Cdc42 to establish a proper growth site in budding yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in axial cellular bud site selection IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytogamy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck contractile ring IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Bud3p
NP_009914.2
  • Guanine nucleotide exchange factor (GEF) for Cdc42p; activates Cdc42p in early G1, accounting for the first stage of biphasic activation, with Cdc24p accounting for the second stage in late G1; involved in the Cdc42p-mediated assembly of the axial landmark that dictates the site for the next round of budding, resulting in the axial budding pattern in haploids; localizes with septins to the bud neck contractile ring in mitosis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    96281..101191
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178662.1 → NP_009914.2  TPA: Bud3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009914.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQZ9, P25556, P25557, P25558, P87007
    UniProtKB/TrEMBL
    A6ZTH1, C7GQK5, N1PAP5
    Conserved Domains (2) summary
    smart00325
    Location:265 → 441
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam12015
    Location:27 → 205
    DUF3507; Domain of unknown function (DUF3507)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25558.2

Gene LinkOut

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