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MGC16025 uncharacterized LOC85009 [ Homo sapiens (human) ]

Gene ID: 85009, updated on 7-Jan-2024

Summary

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Gene symbol
MGC16025
Gene description
uncharacterized LOC85009
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
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Genomic context

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See MGC16025 in Genome Data Viewer
Location:
2q37.3
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (239193331..239195457, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (239684488..239686614, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (240115027..240117153, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene histone deacetylase 4 Neighboring gene microRNA 4441 Neighboring gene uncharacterized LOC124908009 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240111156-240111673 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240111674-240112190 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240112520-240113118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240117946-240118446 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240123022-240123588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240134871-240135376 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240136104-240136802 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240136803-240137501 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240146814-240147708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240152211-240152711 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240153455-240153994 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240165567-240166264 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:240168807-240170006 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240174119-240174620 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240183749-240184248 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240185799-240186466 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17384 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17385 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240194739-240195516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17386 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:240197413-240197621 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240213415-240213946 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240212885-240213414 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12499 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:240217222-240217838 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240217839-240218454 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17387 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240229260-240229906 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240232601-240233101 Neighboring gene microRNA 4269 Neighboring gene microRNA 2467

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. IRES-dependent translation of the long non coding RNA meloe in melanoma cells produces the most immunogenic MELOE antigens. Charpentier M, et al. Oncotarget, 2016 Sep 13. PMID 27486971, Free PMC Article
  2. Overexpression of meloe gene in melanomas is controlled both by specific transcription factors and hypomethylation. Bobinet M, et al. PLoS One, 2013. PMID 24086527, Free PMC Article
  3. The melanoma antigens MELOE-1 and MELOE-2 are translated from a bona fide polycistronic mRNA containing functional IRES sequences. Carbonnelle D, et al. PLoS One, 2013. PMID 24086473, Free PMC Article
  4. Frequent occurrence of high affinity T cells against MELOE-1 makes this antigen an attractive target for melanoma immunotherapy. Godet Y, et al. Eur J Immunol, 2010 Jun. PMID 20217862
  5. MELOE-1 is a new antigen overexpressed in melanomas and involved in adoptive T cell transfer efficiency. Godet Y, et al. J Exp Med, 2008 Oct 27. PMID 18936238, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate the expression of an additional ORF, MELOE-3, located in the 5' region of meloe.
    Title: IRES-dependent translation of the long non coding RNA meloe in melanoma cells produces the most immunogenic MELOE antigens.
  2. Overexpression of meloe gene in melanomas is controlled both by specific transcription factors and hypomethylation.
    Title: Overexpression of meloe gene in melanomas is controlled both by specific transcription factors and hypomethylation.
  3. meloe is a polycistronic mRNA that generates both MELOE-1 and MELOE-2 antigens through IRES-dependent translation in melanoma cells and that may explain their tumor specificity.
    Title: The melanoma antigens MELOE-1 and MELOE-2 are translated from a bona fide polycistronic mRNA containing functional IRES sequences.
  4. study documents the existence of a large TCR repertoire specific for the MELOE-1/A2 epitope
    Title: Frequent occurrence of high affinity T cells against MELOE-1 makes this antigen an attractive target for melanoma immunotherapy.
  5. MELOE-1 is a new antigen overexpressed in melanomas and involved in adoptive T cell transfer efficiency.
    Title: MELOE-1 is a new antigen overexpressed in melanomas and involved in adoptive T cell transfer efficiency.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_026664.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC017028

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    239193331..239195457 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    239684488..239686614 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_032923.1: Suppressed sequence

    Description
    NM_032923.1: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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