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RERG RAS like estrogen regulated growth inhibitor [ Homo sapiens (human) ]

Gene ID: 85004, updated on 5-Mar-2024

Summary

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Official Symbol
RERGprovided by HGNC
Official Full Name
RAS like estrogen regulated growth inhibitorprovided by HGNC
Primary source
HGNC:HGNC:15980
See related
Ensembl:ENSG00000134533 MIM:612664; AllianceGenome:HGNC:15980
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
RERG, a member of the RAS superfamily of GTPases, inhibits cell proliferation and tumor formation (Finlin et al., 2001 [PubMed 11533059]).[supplied by OMIM, Mar 2009]
Expression
Broad expression in endometrium (RPKM 41.3), adrenal (RPKM 21.0) and 16 other tissues See more
Orthologs
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Genomic context

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See RERG in Genome Data Viewer
Location:
12p12.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (15107783..15221417, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (14985067..15098688, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (15260717..15374351, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6065 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4277 Neighboring gene long intergenic non-protein coding RNA 1489 Neighboring gene phosphodiesterase 6H Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:15191267-15191767 Neighboring gene RERG intronic transcript 1 Neighboring gene uncharacterized LOC124902887 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:15332809-15332980 Neighboring gene RERG antisense RNA 1 Neighboring gene uncharacterized LOC124902886 Neighboring gene uncharacterized LOC105369673 Neighboring gene methyltransferase like 8 pseudogene 1 Neighboring gene protein tyrosine phosphatase receptor type O

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. RERG (Ras-like, oestrogen-regulated, growth-inhibitor) expression in breast cancer: a marker of ER-positive luminal-like subtype. Habashy HO, et al. Breast Cancer Res Treat, 2011 Jul. PMID 20697807
  2. ERK5‑regulated RERG expression promotes cancer progression in prostatic carcinoma. Xiong Y, et al. Oncol Rep, 2019 Feb. PMID 30431143
  3. MicroRNA-382-5p aggravates breast cancer progression by regulating the RERG/Ras/ERK signaling axis. Ho JY, et al. Oncotarget, 2017 Apr 4. PMID 27705918, Free PMC Article
  4. ERβ- and prostaglandin E2-regulated pathways integrate cell proliferation via Ras-like and estrogen-regulated growth inhibitor in endometriosis. Monsivais D, et al. Mol Endocrinol, 2014 Aug. PMID 24992181, Free PMC Article
  5. NF-κB-mediated miR-650 plays oncogenic roles and activates AKT/ERK/NF-κB pathways by targeting RERG in glioma cells. Jin S, et al. Cell Oncol (Dordr), 2020 Dec. PMID 32986146

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NF-kappaB-mediated miR-650 plays oncogenic roles and activates AKT/ERK/NF-kappaB pathways by targeting RERG in glioma cells.
    Title: NF-κB-mediated miR-650 plays oncogenic roles and activates AKT/ERK/NF-κB pathways by targeting RERG in glioma cells.
  2. Study revealed that ERK5 can inhibit Raslike oestrogenregulated growth inhibitor (RERG) protein expression and that the inhibition of RERG expression promotes prostatic carcinoma cell proliferation and migration.
    Title: ERK5‑regulated RERG expression promotes cancer progression in prostatic carcinoma.
  3. In particular, methylation levels of ITGA4, RERG, and ZNF671 could distinguish Nasopharyngeal carcinoma (NPC) patients from non-cancer nasopharyngeal epithelium (NNE) subjects. We identified the DNA methylation rates of previously unidentified NPC candidate genes.
    Title: Quantitation of DNA methylation in Epstein-Barr virus-associated nasopharyngeal carcinoma by bisulfite amplicon sequencing.
  4. this study shows that miR-382-5p expression is negatively correlated with RERG expression, and functions as an independent oncomiR for the higher incidence and poorer prognosis of breast cancer
    Title: MicroRNA-382-5p aggravates breast cancer progression by regulating the RERG/Ras/ERK signaling axis.
  5. Estradiol estrogen receptor-beta and PGE2 integrate at RERG, leading to increased endometriotic cell proliferation.
    Title: ERβ- and prostaglandin E2-regulated pathways integrate cell proliferation via Ras-like and estrogen-regulated growth inhibitor in endometriosis.
  6. Results describe the mRNA expression of CRABP1, RERG, and GRP in pituitary adenomas.
    Title: Expression of CRABP1, GRP, and RERG mRNA in clinically non-functioning and functioning pituitary adenomas.
  7. Loss of RERG expression is associated with breast cancer and distant metastasis.
    Title: RERG (Ras-like, oestrogen-regulated, growth-inhibitor) expression in breast cancer: a marker of ER-positive luminal-like subtype.
  8. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
  9. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic susceptibility to distinct bladder cancer subphenotypes.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC15754

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GDP binding TAS
Traceable Author Statement
more info
 PubMed 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear estrogen receptor binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of cell growth IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to hormone IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in small GTPase-mediated signal transduction NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fibrillar center IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ras-related and estrogen-regulated growth inhibitor
NP_001177655.1
NP_116307.1
XP_047285753.1
XP_047285754.1
XP_054229660.1
XP_054229661.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190726.2 → NP_001177655.1  ras-related and estrogen-regulated growth inhibitor isoform 2

    See identical proteins and their annotated locations for NP_001177655.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK295343, BC007997
    Consensus CDS
    CCDS53753.1
    UniProtKB/Swiss-Prot
    Q96A58
    Related
    ENSP00000444485.1, ENST00000546331.5
    Conserved Domains (1) summary
    cl38936
    Location:8 → 150
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_032918.3 → NP_116307.1  ras-related and estrogen-regulated growth inhibitor isoform 1

    See identical proteins and their annotated locations for NP_116307.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC007997, DC331754
    Consensus CDS
    CCDS8673.1
    UniProtKB/Swiss-Prot
    B2R9R0, B4DI02, Q96A58
    Related
    ENSP00000256953.2, ENST00000256953.6
    Conserved Domains (1) summary
    cd04146
    Location:8 → 169
    RERG_RasL11_like; Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    15107783..15221417 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047429797.1 → XP_047285753.1  ras-related and estrogen-regulated growth inhibitor isoform X1

  2. XM_047429798.1 → XP_047285754.1  ras-related and estrogen-regulated growth inhibitor isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    14985067..15098688 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373685.1 → XP_054229660.1  ras-related and estrogen-regulated growth inhibitor isoform X1

  2. XM_054373686.1 → XP_054229661.1  ras-related and estrogen-regulated growth inhibitor isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96A58.1 GenPept UniProtKB/Swiss-Prot:Q96A58

Gene LinkOut

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