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UBL7 ubiquitin like 7 [ Homo sapiens (human) ]

Gene ID: 84993, updated on 5-Mar-2024

Summary

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Official Symbol
UBL7provided by HGNC
Official Full Name
ubiquitin like 7provided by HGNC
Primary source
HGNC:HGNC:28221
See related
Ensembl:ENSG00000138629 MIM:609748; AllianceGenome:HGNC:28221
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TCBA1; BMSC-UbP
Summary
Predicted to enable polyubiquitin modification-dependent protein binding activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 17.2), brain (RPKM 14.5) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
15q24.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (74445977..74461188, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (72313701..72328914, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (74738318..74753529, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9751 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9752 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74675326-74675826 Neighboring gene long intergenic non-protein coding RNA 2255 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9753 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:74676645-74677844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74678372-74678912 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74678913-74679452 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:74679453-74679994 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:74679995-74680534 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:74680535-74681075 Neighboring gene CRISPRi-validated cis-regulatory element chr15.2230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9757 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9758 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:74688843-74690042 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74692014-74692514 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74693783-74694283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9764 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74695428-74696393 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9768 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9769 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9770 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9771 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74701581-74702081 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74703990-74704490 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74704491-74704991 Neighboring gene semaphorin 7A (JohnMiltonHagen blood group) Neighboring gene microRNA 6881 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:74713934-74714565 Neighboring gene Sharpr-MPRA regulatory region 521 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:74715829-74716459 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9773 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9774 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9775 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6649 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6650 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6651 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:74734123-74734632 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:74734999-74735183 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:74735145-74735654 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:74741828-74742328 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9776 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74751547-74752066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74752067-74752586 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:74752742-74753588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74754520-74755020 Neighboring gene UBL7 divergent transcript Neighboring gene small nucleolar RNA SNORD77

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Solution structure of the ubiquitin-associated domain of human BMSC-UbP and its complex with ubiquitin. Chang YG, et al. Protein Sci, 2006 Jun. PMID 16731964, Free PMC Article
  2. Cloning and identification of a novel ubiquitin-like protein, BMSC-UbP, from human bone marrow stromal cells. Liu S, et al. Immunol Lett, 2003 Apr 3. PMID 12644319
  3. UBL7 enhances antiviral innate immunity by promoting Lys27-linked polyubiquitination of MAVS. Jiang W, et al. Cell Rep, 2023 Mar 28. PMID 36943869
  4. Selectivity of the CUBAN domain in the recognition of ubiquitin and NEDD8. Castagnoli L, et al. FEBS J, 2019 Feb. PMID 30659753
  5. Identification of polyubiquitin binding proteins involved in NF-kappaB signaling using protein arrays. Fenner BJ, et al. Biochim Biophys Acta, 2009 Jul. PMID 19285159

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the solution NMR structure of the ubiquitin-associated domain of the human BMSC-UbP protein and its complex with ubiquitin
    Title: Solution structure of the ubiquitin-associated domain of human BMSC-UbP and its complex with ubiquitin.
  2. BMSC-UbP might play roles in regulation of BMSC function or cell differentiation through an evocator- and cell-specific pattern.
    Title: Cloning and identification of a novel ubiquitin-like protein, BMSC-UbP, from human bone marrow stromal cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC14421

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin-like protein 7
Names
ubiquitin-like 7 (bone marrow stromal cell-derived)
ubiquitin-like protein SB132

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286739.2 → NP_001273668.1  ubiquitin-like protein 7 isoform a

    See identical proteins and their annotated locations for NP_001273668.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (a).
    Source sequence(s)
    BC030055, BG704085, HY135530
    Consensus CDS
    CCDS10263.1
    UniProtKB/Swiss-Prot
    D3DW57, Q96I03, Q96S82
    Related
    ENSP00000457708.1, ENST00000565335.5
    Conserved Domains (2) summary
    cd01815
    Location:18 → 92
    BMSC_UbP_N; Ubiquitin-like domain of BMSC-UbP
    cd14326
    Location:346 → 375
    UBA_UBL7; UBA domain found in ubiquitin-like protein 7 (UBL7) and similar proteins

  2. NM_001286740.1 → NP_001273669.1  ubiquitin-like protein 7 isoform a

    See identical proteins and their annotated locations for NP_001273669.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (a).
    Source sequence(s)
    BC007913, HY135530
    Consensus CDS
    CCDS10263.1
    UniProtKB/Swiss-Prot
    D3DW57, Q96I03, Q96S82
    Conserved Domains (2) summary
    cd01815
    Location:18 → 92
    BMSC_UbP_N; Ubiquitin-like domain of BMSC-UbP
    cd14326
    Location:346 → 375
    UBA_UBL7; UBA domain found in ubiquitin-like protein 7 (UBL7) and similar proteins

  3. NM_001286741.2 → NP_001273670.1  ubiquitin-like protein 7 isoform b

    See identical proteins and their annotated locations for NP_001273670.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a longer N-terminus, compared to isoform a. Both variants 5 and 6 encode the same isoform.
    Source sequence(s)
    BC007913, BP192909
    Conserved Domains (3) summary
    cd01815
    Location:58 → 132
    BMSC_UbP_N; Ubiquitin-like domain of BMSC-UbP
    smart00213
    Location:79 → 130
    UBQ; Ubiquitin homologues
    cd14326
    Location:386 → 415
    UBA_UBL7; UBA domain found in ubiquitin-like protein 7 (UBL7) and similar proteins

  4. NM_001286742.2 → NP_001273671.1  ubiquitin-like protein 7 isoform b

    See identical proteins and their annotated locations for NP_001273671.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a longer N-terminus, compared to isoform a. Both variants 5 and 6 encode the same isoform.
    Source sequence(s)
    BC030055, BC033919, BP192909
    Conserved Domains (3) summary
    cd01815
    Location:58 → 132
    BMSC_UbP_N; Ubiquitin-like domain of BMSC-UbP
    smart00213
    Location:79 → 130
    UBQ; Ubiquitin homologues
    cd14326
    Location:386 → 415
    UBA_UBL7; UBA domain found in ubiquitin-like protein 7 (UBL7) and similar proteins

  5. NM_032907.5 → NP_116296.1  ubiquitin-like protein 7 isoform a

    See identical proteins and their annotated locations for NP_116296.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the shorter isoform (a). Variants 1-4 encode the same isoform.
    Source sequence(s)
    BC007913, BP192909
    Consensus CDS
    CCDS10263.1
    UniProtKB/Swiss-Prot
    D3DW57, Q96I03, Q96S82
    Related
    ENSP00000378518.2, ENST00000395081.7
    Conserved Domains (2) summary
    cd01815
    Location:18 → 92
    BMSC_UbP_N; Ubiquitin-like domain of BMSC-UbP
    cd14326
    Location:346 → 375
    UBA_UBL7; UBA domain found in ubiquitin-like protein 7 (UBL7) and similar proteins

  6. NM_201265.2 → NP_957717.1  ubiquitin-like protein 7 isoform a

    See identical proteins and their annotated locations for NP_957717.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (a).
    Source sequence(s)
    BC007913, BI552240
    Consensus CDS
    CCDS10263.1
    UniProtKB/Swiss-Prot
    D3DW57, Q96I03, Q96S82
    Related
    ENSP00000354883.4, ENST00000361351.8
    Conserved Domains (2) summary
    cd01815
    Location:18 → 92
    BMSC_UbP_N; Ubiquitin-like domain of BMSC-UbP
    cd14326
    Location:346 → 375
    UBA_UBL7; UBA domain found in ubiquitin-like protein 7 (UBL7) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    74445977..74461188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522124.3 → XP_011520426.1  ubiquitin-like protein 7 isoform X1

    See identical proteins and their annotated locations for XP_011520426.1

    Conserved Domains (3) summary
    cd01815
    Location:58 → 132
    BMSC_UbP_N; Ubiquitin-like domain of BMSC-UbP
    smart00213
    Location:79 → 130
    UBQ; Ubiquitin homologues
    cd14326
    Location:386 → 415
    UBA_UBL7; UBA domain found in ubiquitin-like protein 7 (UBL7) and similar proteins

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160016.1 Reference GRCh38.p14 PATCHES

    Range
    275246..290457 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332567.1 → XP_054188542.1  ubiquitin-like protein 7 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    72313701..72328914 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379032.1 → XP_054235007.1  ubiquitin-like protein 7 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96S82.2 GenPept UniProtKB/Swiss-Prot:Q96S82

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