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PPFIA2 PTPRF interacting protein alpha 2 [ Homo sapiens (human) ]

Gene ID: 8499, updated on 7-Apr-2024

Summary

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Official Symbol
PPFIA2provided by HGNC
Official Full Name
PTPRF interacting protein alpha 2provided by HGNC
Primary source
HGNC:HGNC:9246
See related
Ensembl:ENSG00000139220 MIM:603143; AllianceGenome:HGNC:9246
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein has been shown to bind the calcium/calmodulin-dependent serine protein kinase (MAGUK family) protein (also known as CASK) and proposed to regulate higher-order brain functions in mammals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Expression
Biased expression in brain (RPKM 7.4), adrenal (RPKM 1.4) and 1 other tissue See more
Orthologs
mouse all
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Genomic context

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Location:
12q21.31
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (81257975..81759350, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (81236956..81738412, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (81651754..82153129, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984535 Neighboring gene NANOG hESC enhancer GRCh37_chr12:81489283-81489784 Neighboring gene acyl-CoA synthetase short chain family member 3 Neighboring gene NANOG hESC enhancer GRCh37_chr12:81602215-81602716 Neighboring gene microRNA 4699 Neighboring gene PPFIA2 antisense RNA 1 Neighboring gene uncharacterized LOC105369872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:82005227-82005726 Neighboring gene NANOG hESC enhancer GRCh37_chr12:82087706-82088318 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:82151989-82152927 Neighboring gene vomeronasal 1 receptor 57 pseudogene Neighboring gene long intergenic non-protein coding RNA 2426

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Liprin alfa 2 gene expression is increased by cannabis use and associated with neuropsychological function. He Y, et al. Eur Neuropsychopharmacol, 2019 May. PMID 30879928
  2. SNP array screening of cryptic genomic imbalances in 450 Japanese subjects with intellectual disability and multiple congenital anomalies previously negative for large rearrangements. Uehara DT, et al. J Hum Genet, 2016 Apr. PMID 26740234
  3. Liprin-alpha2 gene, protein tyrosine phosphatase LAR interacting protein related gene, is downregulated by androgens in the human prostate cancer cell line LNCaP. Fujinami K, et al. Int J Mol Med, 2002 Aug. PMID 12119554
  4. Liprin-mediated large signaling complex organization revealed by the liprin-α/CASK and liprin-α/liprin-β complex structures. Wei Z, et al. Mol Cell, 2011 Aug 19. PMID 21855798
  5. Association mapping of the high-grade myopia MYP3 locus reveals novel candidates UHRF1BP1L, PTPRR, and PPFIA2. Hawthorne F, et al. Invest Ophthalmol Vis Sci, 2013 Mar 21. PMID 23422819, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Liprin alfa 2 gene expression is increased by cannabis use and associated with neuropsychological function.
    Title: Liprin alfa 2 gene expression is increased by cannabis use and associated with neuropsychological function.
  2. mong the 22 cases, we identified PPFIA2 as a novel candidate gene forIntellect Analysis of copy-neutral loss of heterozygosity (CNLOH) detected one case in which the CNLOH regions seem to be significant. The SNP array detected a modest fraction of small causative CNVs, which is explained by the fact that the majority of causative CNVs have larger sizes, and those had been mostly identified in the two previous screenings.
    Title: SNP array screening of cryptic genomic imbalances in 450 Japanese subjects with intellectual disability and multiple congenital anomalies previously negative for large rearrangements.
  3. 3 genes identified by association study and supported by ocular expression and/or replication, UHRF1BP1L, PTPRR, and PPFIA2, are novel candidates for myopic development within the MYP3 locus that should be further studied.
    Title: Association mapping of the high-grade myopia MYP3 locus reveals novel candidates UHRF1BP1L, PTPRR, and PPFIA2.
  4. Liprins can mediate assembly of target proteins into large protein complexes capable of regulating numerous cellular activities.
    Title: Liprin-mediated large signaling complex organization revealed by the liprin-α/CASK and liprin-α/liprin-β complex structures.
  5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  6. Liprin-alpha2 expression is downregulated by androgens in prostate cancer cells. It might play a role in androgen-responsive human prostate cancer & the loss of this gene expression might be associated with the androgen-independence.
    Title: Liprin-alpha2 gene, protein tyrosine phosphatase LAR interacting protein related gene, is downregulated by androgens in the human prostate cancer cell line LNCaP.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
EBI GWAS Catalog
Electronic medical records and genomics (eMERGE) network exploration in cataract: Several new potential susceptibility loci.
EBI GWAS Catalog
Genome-wide association study of multiplex schizophrenia pedigrees.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Screening in Jurkat T-cells with a short-hairpin-RNA (shRNA) library identifies protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 (PPFIA2) is important for HIV-1 replication PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ41378, MGC132572

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of presynapse IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell-matrix adhesion TAS
Traceable Author Statement
more info
 PubMed 
involved_in dense core granule cytoskeletal transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in presynapse organization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of dendritic spine development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synaptic vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in synapse organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in dendritic spine IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic specialization IEA
Inferred from Electronic Annotation
more info
  
is_active_in presynaptic active zone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in presynaptic active zone TAS
Traceable Author Statement
more info
 PubMed 
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
liprin-alpha-2
Names
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001220473.3 → NP_001207402.1  liprin-alpha-2 isoform b

    See identical proteins and their annotated locations for NP_001207402.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has multiple differences in the UTRs and coding region, compared to variant 1. It encodes isoform b, which is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AB210009, AW304872, BM661844
    Consensus CDS
    CCDS59236.1
    UniProtKB/TrEMBL
    G3V200, Q4LE62
    Related
    ENSP00000449558.2, ENST00000550584.6
    Conserved Domains (4) summary
    cd09562
    Location:895 → 965
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:1019 → 1084
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1104 → 1175
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:201 → 533
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. NM_001220474.3 → NP_001207403.1  liprin-alpha-2 isoform c

    See identical proteins and their annotated locations for NP_001207403.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences in the UTRs and coding region, compared to variant 1. It encodes isoform c, which is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AB210009, AK126971, AW304872, BQ027545, CB051855, DA329958, EL947964
    Consensus CDS
    CCDS55854.1
    UniProtKB/TrEMBL
    Q4LE62
    Related
    ENSP00000450298.1, ENST00000549325.5
    Conserved Domains (5) summary
    cd09562
    Location:880 → 950
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:1004 → 1069
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1089 → 1160
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:183 → 515
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam05622
    Location:41 → 272
    HOOK; HOOK protein

  3. NM_001220475.2 → NP_001207404.1  liprin-alpha-2 isoform d

    See identical proteins and their annotated locations for NP_001207404.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame exon in the coding region, compared to variant 1. It encodes isoform d, which is shorter than isoform a.
    Source sequence(s)
    AB210009, AW304872, BC104912, BM661844, CB051855, EL947964
    Consensus CDS
    CCDS55855.1
    UniProtKB/TrEMBL
    Q4LE62
    Conserved Domains (4) summary
    cd09562
    Location:895 → 965
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:998 → 1063
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1083 → 1154
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    cl25732
    Location:201 → 533
    SMC_N; RecF/RecN/SMC N terminal domain

  4. NM_001220476.2 → NP_001207405.1  liprin-alpha-2 isoform e

    See identical proteins and their annotated locations for NP_001207405.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 1. It encodes isoform e, which is shorter than isoform a.
    Source sequence(s)
    AB210009, AW304872, BC143485, BM661844, CB051855, EL947964
    Consensus CDS
    CCDS55856.1
    UniProtKB/TrEMBL
    Q4LE62
    Conserved Domains (4) summary
    cd09562
    Location:895 → 965
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:1013 → 1078
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1098 → 1169
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    cl25732
    Location:201 → 533
    SMC_N; RecF/RecN/SMC N terminal domain

  5. NM_001220477.2 → NP_001207406.1  liprin-alpha-2 isoform f

    See identical proteins and their annotated locations for NP_001207406.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has multiple differences in the 5' UTR and coding region, compared to variant 1. It encodes isoform f, which is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AK299853, AL713132, AW304872, BM661844, CB051855, DA329958, EL947964
    Consensus CDS
    CCDS55853.1
    UniProtKB/TrEMBL
    B7Z7Y5
    Related
    ENSP00000385093.4, ENST00000407050.8
    Conserved Domains (4) summary
    cd09562
    Location:821 → 891
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:918 → 983
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1003 → 1074
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:127 → 459
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  6. NM_001220478.2 → NP_001207407.1  liprin-alpha-2 isoform g

    See identical proteins and their annotated locations for NP_001207407.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has multiple differences in the 5' UTR and coding region, compared to variant 1. It encodes isoform g, which is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AK294505, AL713132, AW304872, BM661844, CB051855, DA687865, DC321269, EL947964
    Consensus CDS
    CCDS55852.1
    UniProtKB/TrEMBL
    B7Z7Y5
    Related
    ENSP00000327416.8, ENST00000333447.11
    Conserved Domains (5) summary
    cd09562
    Location:796 → 866
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:914 → 979
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:999 → 1070
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:94 → 434
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:323 → 589
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  7. NM_001220479.3 → NP_001207408.1  liprin-alpha-2 isoform h

    See identical proteins and their annotated locations for NP_001207408.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) has multiple differences in the 5' UTR and coding region, compared to variant 1. It encodes isoform h, which is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK296380, AW304872, BM661844, CB051855, EL947964
    Consensus CDS
    CCDS55851.1
    UniProtKB/Swiss-Prot
    O75334
    Related
    ENSP00000438337.2, ENST00000541570.6
    Conserved Domains (4) summary
    cd09562
    Location:462 → 532
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:555 → 620
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:640 → 711
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    cl25732
    Location:7 → 264
    SMC_N; RecF/RecN/SMC N terminal domain

  8. NM_001220480.3 → NP_001207409.1  liprin-alpha-2 isoform i

    See identical proteins and their annotated locations for NP_001207409.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) has multiple differences in the 5' UTR and coding region but maintains the reading frame, compared to variant 1. This results in a shorter protein (isoform i), compared to isoform a.
    Source sequence(s)
    AK123372, AW304872, BM689808, CB051855, DC322478, EL947964
    Consensus CDS
    CCDS55850.1
    UniProtKB/Swiss-Prot
    O75334
    Related
    ENSP00000445532.1, ENST00000541017.5
    Conserved Domains (3) summary
    cd09562
    Location:112 → 182
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:205 → 270
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:290 → 361
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3

  9. NM_001282536.1 → NP_001269465.1  liprin-alpha-2 isoform j

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) uses an alternate 5' exon structure, and thus differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (j) with a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AK302658, AW304872, BM661844, BU568524, CB051855, DB083201, EL947964
    Consensus CDS
    CCDS73503.1
    UniProtKB/TrEMBL
    B7Z7Y5, H0YHK3
    Related
    ENSP00000447273.2, ENST00000550359.6
    Conserved Domains (4) summary
    cd09562
    Location:742 → 812
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:866 → 931
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:951 → 1022
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    cl25732
    Location:36 → 380
    SMC_N; RecF/RecN/SMC N terminal domain

  10. NM_003625.5 → NP_003616.2  liprin-alpha-2 isoform a

    See identical proteins and their annotated locations for NP_003616.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC079408, AF034799, AW304872, BM661844, CB051855, DA329958, DA368637, DA533482, EL947964
    Consensus CDS
    CCDS55857.1
    UniProtKB/Swiss-Prot
    B3KVT5, B3KXA0, B7Z2A6, B7Z3U9, B7Z663, B7ZKZ5, E7ERB8, E7ETG6, F8VP68, O75334, Q2M3G8
    UniProtKB/TrEMBL
    Q4LE62
    Related
    ENSP00000450337.1, ENST00000549396.6
    Conserved Domains (4) summary
    cd09562
    Location:895 → 965
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:1019 → 1084
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1104 → 1175
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:201 → 533
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    81257975..81759350 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449242.2 → XP_024305010.1  liprin-alpha-2 isoform X30

    UniProtKB/TrEMBL
    Q4LE62
    Conserved Domains (4) summary
    cd09562
    Location:895 → 965
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:988 → 1053
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1073 → 1144
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    cl25732
    Location:201 → 533
    SMC_N; RecF/RecN/SMC N terminal domain

  2. XM_017020107.3 → XP_016875596.1  liprin-alpha-2 isoform X27

    UniProtKB/TrEMBL
    Q4LE62

  3. XM_024449240.2 → XP_024305008.1  liprin-alpha-2 isoform X14

    UniProtKB/TrEMBL
    Q4LE62
    Conserved Domains (4) summary
    cd09562
    Location:895 → 965
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:1009 → 1074
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1094 → 1165
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    cl25732
    Location:201 → 533
    SMC_N; RecF/RecN/SMC N terminal domain

  4. XM_017020090.3 → XP_016875579.1  liprin-alpha-2 isoform X11

    UniProtKB/TrEMBL
    Q4LE62

  5. XM_017020086.2 → XP_016875575.1  liprin-alpha-2 isoform X7

    UniProtKB/TrEMBL
    G3V200, Q4LE62
    Conserved Domains (4) summary
    cd09562
    Location:895 → 965
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:1019 → 1084
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1104 → 1175
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:201 → 533
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  6. XM_017020108.3 → XP_016875597.1  liprin-alpha-2 isoform X29

    UniProtKB/TrEMBL
    Q4LE62

  7. XM_047429786.1 → XP_047285742.1  liprin-alpha-2 isoform X20

  8. XM_047429781.1 → XP_047285737.1  liprin-alpha-2 isoform X12

  9. XM_047429778.1 → XP_047285734.1  liprin-alpha-2 isoform X9

  10. XM_047429775.1 → XP_047285731.1  liprin-alpha-2 isoform X5

  11. XM_017020099.2 → XP_016875588.1  liprin-alpha-2 isoform X19

    UniProtKB/TrEMBL
    Q4LE62

  12. XM_017020105.2 → XP_016875594.1  liprin-alpha-2 isoform X26

    UniProtKB/TrEMBL
    Q4LE62

  13. XM_047429791.1 → XP_047285747.1  liprin-alpha-2 isoform X31

  14. XM_017020103.3 → XP_016875592.1  liprin-alpha-2 isoform X22

    UniProtKB/TrEMBL
    Q4LE62

  15. XM_017020088.2 → XP_016875577.1  liprin-alpha-2 isoform X10

    UniProtKB/TrEMBL
    Q4LE62

  16. XM_047429788.1 → XP_047285744.1  liprin-alpha-2 isoform X23

  17. XM_047429785.1 → XP_047285741.1  liprin-alpha-2 isoform X18

  18. XM_017020094.3 → XP_016875583.1  liprin-alpha-2 isoform X16

    UniProtKB/TrEMBL
    Q4LE62

  19. XM_024449241.2 → XP_024305009.1  liprin-alpha-2 isoform X28

    UniProtKB/TrEMBL
    Q4LE62
    Conserved Domains (4) summary
    cd09562
    Location:895 → 965
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:982 → 1047
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1067 → 1138
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    cl25732
    Location:201 → 533
    SMC_N; RecF/RecN/SMC N terminal domain

  20. XM_047429789.1 → XP_047285745.1  liprin-alpha-2 isoform X24

  21. XM_047429783.1 → XP_047285739.1  liprin-alpha-2 isoform X15

    Related
    ENSP00000447868.1, ENST00000552948.5

  22. XM_047429777.1 → XP_047285733.1  liprin-alpha-2 isoform X8

  23. XM_047429774.1 → XP_047285730.1  liprin-alpha-2 isoform X4

    Related
    ENSP00000449338.1, ENST00000548586.5

  24. XM_047429790.1 → XP_047285746.1  liprin-alpha-2 isoform X25

  25. XM_047429787.1 → XP_047285743.1  liprin-alpha-2 isoform X21

  26. XM_047429784.1 → XP_047285740.1  liprin-alpha-2 isoform X17

  27. XM_047429782.1 → XP_047285738.1  liprin-alpha-2 isoform X13

  28. XM_047429776.1 → XP_047285732.1  liprin-alpha-2 isoform X6

  29. XM_047429773.1 → XP_047285729.1  liprin-alpha-2 isoform X3

  30. XM_047429770.1 → XP_047285726.1  liprin-alpha-2 isoform X1

  31. XM_047429796.1 → XP_047285752.1  liprin-alpha-2 isoform X38

  32. XM_047429795.1 → XP_047285751.1  liprin-alpha-2 isoform X37

  33. XM_047429780.1 → XP_047285736.1  liprin-alpha-2 isoform X10

  34. XM_047429772.1 → XP_047285728.1  liprin-alpha-2 isoform X2

    UniProtKB/Swiss-Prot
    B3KVT5, B3KXA0, B7Z2A6, B7Z3U9, B7Z663, B7ZKZ5, E7ERB8, E7ETG6, F8VP68, O75334, Q2M3G8

  35. XM_047429771.1 → XP_047285727.1  liprin-alpha-2 isoform X1

  36. XM_017020118.2 → XP_016875607.1  liprin-alpha-2 isoform X33

    UniProtKB/TrEMBL
    B7Z7Y5

  37. XM_047429794.1 → XP_047285750.1  liprin-alpha-2 isoform X34

  38. XM_047429793.1 → XP_047285749.1  liprin-alpha-2 isoform X32

  39. XM_047429792.1 → XP_047285748.1  liprin-alpha-2 isoform X32

  40. XM_024449245.2 → XP_024305013.1  liprin-alpha-2 isoform X36

    Conserved Domains (4) summary
    cd09562
    Location:490 → 560
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:614 → 679
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:699 → 770
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    cl25732
    Location:1 → 289
    SMC_N; RecF/RecN/SMC N terminal domain

  41. XM_024449244.2 → XP_024305012.1  liprin-alpha-2 isoform X35

    Conserved Domains (1) summary
    cl25732
    Location:201 → 533
    SMC_N; RecF/RecN/SMC N terminal domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    81236956..81738412 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373675.1 → XP_054229650.1  liprin-alpha-2 isoform X30

  2. XM_054373672.1 → XP_054229647.1  liprin-alpha-2 isoform X27

  3. XM_054373658.1 → XP_054229633.1  liprin-alpha-2 isoform X11

  4. XM_054373654.1 → XP_054229629.1  liprin-alpha-2 isoform X7

    UniProtKB/TrEMBL
    G3V200

  5. XM_054373674.1 → XP_054229649.1  liprin-alpha-2 isoform X29

  6. XM_054373665.1 → XP_054229640.1  liprin-alpha-2 isoform X20

  7. XM_054373655.1 → XP_054229630.1  liprin-alpha-2 isoform X9

  8. XM_054373653.1 → XP_054229628.1  liprin-alpha-2 isoform X5

  9. XM_054373664.1 → XP_054229639.1  liprin-alpha-2 isoform X19

  10. XM_054373671.1 → XP_054229646.1  liprin-alpha-2 isoform X26

  11. XM_054373676.1 → XP_054229651.1  liprin-alpha-2 isoform X31

  12. XM_054373667.1 → XP_054229642.1  liprin-alpha-2 isoform X22

  13. XM_054373656.1 → XP_054229631.1  liprin-alpha-2 isoform X10

  14. XM_054373668.1 → XP_054229643.1  liprin-alpha-2 isoform X23

  15. XM_054373663.1 → XP_054229638.1  liprin-alpha-2 isoform X18

  16. XM_054373661.1 → XP_054229636.1  liprin-alpha-2 isoform X16

  17. XM_054373673.1 → XP_054229648.1  liprin-alpha-2 isoform X28

  18. XM_054373669.1 → XP_054229644.1  liprin-alpha-2 isoform X24

  19. XM_054373660.1 → XP_054229635.1  liprin-alpha-2 isoform X15

  20. XM_054373652.1 → XP_054229627.1  liprin-alpha-2 isoform X4

  21. XM_054373670.1 → XP_054229645.1  liprin-alpha-2 isoform X25

  22. XM_054373666.1 → XP_054229641.1  liprin-alpha-2 isoform X21

  23. XM_054373662.1 → XP_054229637.1  liprin-alpha-2 isoform X17

  24. XM_054373659.1 → XP_054229634.1  liprin-alpha-2 isoform X13

  25. XM_054373651.1 → XP_054229626.1  liprin-alpha-2 isoform X3

  26. XM_054373648.1 → XP_054229623.1  liprin-alpha-2 isoform X1

  27. XM_054373684.1 → XP_054229659.1  liprin-alpha-2 isoform X38

  28. XM_054373683.1 → XP_054229658.1  liprin-alpha-2 isoform X37

  29. XM_054373657.1 → XP_054229632.1  liprin-alpha-2 isoform X10

  30. XM_054373650.1 → XP_054229625.1  liprin-alpha-2 isoform X2

    UniProtKB/Swiss-Prot
    B3KVT5, B3KXA0, B7Z2A6, B7Z3U9, B7Z663, B7ZKZ5, E7ERB8, E7ETG6, F8VP68, O75334, Q2M3G8

  31. XM_054373649.1 → XP_054229624.1  liprin-alpha-2 isoform X1

  32. XM_054373679.1 → XP_054229654.1  liprin-alpha-2 isoform X33

  33. XM_054373680.1 → XP_054229655.1  liprin-alpha-2 isoform X34

  34. XM_054373678.1 → XP_054229653.1  liprin-alpha-2 isoform X32

  35. XM_054373677.1 → XP_054229652.1  liprin-alpha-2 isoform X32

  36. XM_054373682.1 → XP_054229657.1  liprin-alpha-2 isoform X36

  37. XM_054373681.1 → XP_054229656.1  liprin-alpha-2 isoform X35

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75334.2 GenPept UniProtKB/Swiss-Prot:O75334

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