U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

C8orf76 chromosome 8 open reading frame 76 [ Homo sapiens (human) ]

Gene ID: 84933, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
C8orf76provided by HGNC
Official Full Name
chromosome 8 open reading frame 76provided by HGNC
Primary source
HGNC:HGNC:25924
See related
Ensembl:ENSG00000189376 AllianceGenome:HGNC:25924
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in colon (RPKM 8.2), lymph node (RPKM 8.0) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
8q24.13
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (123219967..123241377, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (124351104..124372514, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (124232207..124253617, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 83 member A Neighboring gene FAM83A antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:124219477-124220229 Neighboring gene microRNA 4663 Neighboring gene ZHX1-C8orf76 readthrough Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:124253403-124253903 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27870 Neighboring gene zinc fingers and homeoboxes 1 Neighboring gene tRNA-Phe (anticodon GAA) 12-1 Neighboring gene RNA, U6 small nuclear 628, pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. C8orf76 Modulates Ferroptosis in Liver Cancer via Transcriptionally Up-Regulating SLC7A11. Li D, et al. Cancers (Basel), 2022 Jul 13. PMID 35884471, Free PMC Article
  2. High Expression of C8orf76 Is an Independent Predictive Factor of Poor Prognosis in Patients with Breast Cancer. Wang Y, et al. Adv Ther, 2022 Jun. PMID 35482249
  3. C8orf76 Promotes Gastric Tumorigenicity and Metastasis by Directly Inducing lncRNA DUSP5P1 and Associates with Patient Outcomes. Wang X, et al. Clin Cancer Res, 2019 May 15. PMID 30733230
  4. Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer. Jung JG, et al. PLoS Genet, 2014 Oct. PMID 25356737, Free PMC Article
  5. The transcriptome of human CD34+ hematopoietic stem-progenitor cells. Kim YC, et al. Proc Natl Acad Sci U S A, 2009 May 19. PMID 19416867, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High Expression of C8orf76 Is an Independent Predictive Factor of Poor Prognosis in Patients with Breast Cancer.
    Title: High Expression of C8orf76 Is an Independent Predictive Factor of Poor Prognosis in Patients with Breast Cancer.
  2. C8orf76 amplication or overexpression plays a pivotal oncogenic role in gastric carcinogenesis and is an independent prognostic factor for gastric cancer patients.
    Title: C8orf76 Promotes Gastric Tumorigenicity and Metastasis by Directly Inducing lncRNA DUSP5P1 and Associates with Patient Outcomes.
  3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Readthrough ZHX1-C8orf76

Readthrough gene: ZHX1-C8orf76, Included gene: ZHX1

Homology

Clone Names

  • MGC9784, FLJ14825

General protein information

Go to the top of the page Help
Preferred Names
uncharacterized protein C8orf76

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032847.3 → NP_116236.1  uncharacterized protein C8orf76

    See identical proteins and their annotated locations for NP_116236.1

    Status: VALIDATED

    Source sequence(s)
    BC067796, DR156993
    Consensus CDS
    CCDS6341.1
    UniProtKB/Swiss-Prot
    Q53HC1, Q96K31
    Related
    ENSP00000276704.4, ENST00000276704.6
    Conserved Domains (2) summary
    TIGR03939
    Location:64 → 199
    PGA_TPR_OMP; poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA
    sd00006
    Location:130 → 159
    TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    123219967..123241377 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    124351104..124372514 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96K31.1 GenPept UniProtKB/Swiss-Prot:Q96K31

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous