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TMEM209 transmembrane protein 209 [ Homo sapiens (human) ]

Gene ID: 84928, updated on 3-Nov-2024

Summary

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Official Symbol
TMEM209provided by HGNC
Official Full Name
transmembrane protein 209provided by HGNC
Primary source
HGNC:HGNC:21898
See related
Ensembl:ENSG00000146842 AllianceGenome:HGNC:21898
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NET31
Summary
Predicted to be located in Golgi apparatus and nuclear envelope. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thyroid (RPKM 8.3), testis (RPKM 7.9) and 25 other tissues See more
Orthologs
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Genomic context

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See TMEM209 in Genome Data Viewer
Location:
7q32.2
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (130164713..130205406, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (131478118..131518796, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (129804553..129845246, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18642 Neighboring gene kelch domain containing 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26645 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:129780805-129781468 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:129781469-129782132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26648 Neighboring gene long intergenic non-protein coding RNA 3008 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18643 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18644 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26649 Neighboring gene uncharacterized LOC124901745 Neighboring gene Sharpr-MPRA regulatory region 12451 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:129844685-129845484 Neighboring gene serine rich single-pass membrane protein 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:129912168-129912820 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:129912821-129913472 Neighboring gene Sharpr-MPRA regulatory region 5425 Neighboring gene carboxypeptidase A2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Critical function for nuclear envelope protein TMEM209 in human pulmonary carcinogenesis. Fujitomo T, et al. Cancer Res, 2012 Aug 15. PMID 22719065
  2. Imprinting analysis of 10 genes and/or transcripts in a 1.5-Mb MEST-flanking region at human chromosome 7q32. Yamada T, et al. Genomics, 2004 Mar. PMID 14962666
  3. Nuclear membrane proteins with potential disease links found by subtractive proteomics. Schirmer EC, et al. Science, 2003 Sep 5. PMID 12958361
  4. Conserved Mitotic Phosphorylation of a Proteasome Subunit Regulates Cell Proliferation. Duan J, et al. Cells, 2021 Nov 8. PMID 34831298, Free PMC Article
  5. A whole genome screen for HIV restriction factors. Liu L, et al. Retrovirology, 2011 Nov 14. PMID 22082156, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Findings indicate that TMEM209 overexpression and TMEM209-NUP205 interaction are critical drivers of lung cancer proliferation.
    Title: Critical function for nuclear envelope protein TMEM209 in human pulmonary carcinogenesis.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of transmembrane protein 209 (TMEM209) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ14803

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 209
Names
testicular tissue protein Li 202

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301163.2 → NP_001288092.1  transmembrane protein 209 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AK027709, BC045618, BC057784, DB021198, HY352956
    Consensus CDS
    CCDS75661.1
    UniProtKB/Swiss-Prot
    Q96SK2
    Related
    ENSP00000417258.1, ENST00000473456.5
    Conserved Domains (1) summary
    pfam09786
    Location:11 → 518
    CytochromB561_N; Cytochrome B561, N terminal

  2. NM_001363478.2 → NP_001350407.1  transmembrane protein 209 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC087071, BC045618, BU430476, DB085214, HY352956
    Consensus CDS
    CCDS87547.1
    Related
    ENSP00000419697.1, ENST00000462753.5
    Conserved Domains (1) summary
    pfam09786
    Location:10 → 559
    CytochromB561_N; Cytochrome B561, N terminal

  3. NM_032842.4 → NP_116231.2  transmembrane protein 209 isoform 1

    See identical proteins and their annotated locations for NP_116231.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC087071, AI589217, BC045618
    Consensus CDS
    CCDS47712.1
    UniProtKB/Swiss-Prot
    A4D1L1, Q49A50, Q6PF00, Q8NCH3, Q96SK2, Q96SL6
    UniProtKB/TrEMBL
    A0A140VJX5
    Related
    ENSP00000380747.2, ENST00000397622.7
    Conserved Domains (1) summary
    pfam09786
    Location:11 → 560
    CytochromB561_N; Cytochrome B561, N terminal

RNA

  1. NR_156699.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BC045618, BF930310, HY352956

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    130164713..130205406 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    131478118..131518796 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96SK2.2 GenPept UniProtKB/Swiss-Prot:Q96SK2

Gene LinkOut

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