U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ADGRG7 adhesion G protein-coupled receptor G7 [ Homo sapiens (human) ]

Gene ID: 84873, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
ADGRG7provided by HGNC
Official Full Name
adhesion G protein-coupled receptor G7provided by HGNC
Primary source
HGNC:HGNC:19241
See related
Ensembl:ENSG00000144820 MIM:612307; AllianceGenome:HGNC:19241
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPR128
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in duodenum (RPKM 18.5), small intestine (RPKM 17.4) and 2 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
3q12.2
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (100609601..100695479)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (103315353..103401238)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (100328445..100414323)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:100126809-100127334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:100127335-100127860 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:100170016-100170553 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:100184868-100185368 Neighboring gene leukemia NUP98 fusion partner 1 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:100195719-100196404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14573 Neighboring gene transmembrane protein 45A Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:100280470-100281334 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20161 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20162 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20163 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:100427906-100428797 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:100428798-100429688 Neighboring gene glia maturation factor beta pseudogene 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:100456051-100456928 Neighboring gene trafficking from ER to golgi regulator Neighboring gene uncharacterized LOC124906260 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_63759 Neighboring gene ABI family member 3 binding protein Neighboring gene Sharpr-MPRA regulatory region 7106

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. TFG, a target of chromosome translocations in lymphoma and soft tissue tumors, fuses to GPR128 in healthy individuals. Chase A, et al. Haematologica, 2010 Jan. PMID 19797732, Free PMC Article
  2. There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. Fredriksson R, et al. Biochem Biophys Res Commun, 2003 Feb 14. PMID 12565841
  3. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Bjarnadóttir TK, et al. Genomics, 2004 Jul. PMID 15203201
  4. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Hamann J, et al. Pharmacol Rev, 2015. PMID 25713288, Free PMC Article
  5. Systematic identification of pathological lamin A interactors. Dittmer TA, et al. Mol Biol Cell, 2014 May. PMID 24623722, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An expressed in-frame TRK-fused gene-G-protein-coupled receptor GPR128 is identified in healthy individuals and in patients with myeloproliferative neoplasms.
    Title: TFG, a target of chromosome translocations in lymphoma and soft tissue tumors, fuses to GPR128 in healthy individuals.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Clone Names

  • FLJ14454, FLJ16382, FLJ29035, MGC142011, MGC163260

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
adhesion G-protein coupled receptor G7
Names
G-protein coupled receptor 128

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308362.1 → NP_001295291.1  adhesion G-protein coupled receptor G7 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple alternate exons in the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC069223, AK172769, AK295345, DA640995
    Consensus CDS
    CCDS77778.1
    UniProtKB/TrEMBL
    B7Z303, E9PHI0
    Related
    ENSP00000419788.1, ENST00000475887.1
    Conserved Domains (2) summary
    pfam01825
    Location:88 → 126
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:138 → 419
    7tm_4; Olfactory receptor

  2. NM_032787.3 → NP_116176.2  adhesion G-protein coupled receptor G7 isoform 1 precursor

    See identical proteins and their annotated locations for NP_116176.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC069223, AK027360, AK172769
    Consensus CDS
    CCDS2938.1
    UniProtKB/Swiss-Prot
    Q14D94, Q86SQ2, Q96K78
    UniProtKB/TrEMBL
    A1L441
    Related
    ENSP00000273352.3, ENST00000273352.8
    Conserved Domains (2) summary
    smart00303
    Location:383 → 422
    GPS; G-protein-coupled receptor proteolytic site domain
    cd15257
    Location:431 → 737
    7tmB2_GPR128; orphan adhesion receptor GPR128, member of the class B2 family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    100609601..100695479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047449088.1 → XP_047305044.1  adhesion G-protein coupled receptor G7 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    103315353..103401238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348147.1 → XP_054204122.1  adhesion G-protein coupled receptor G7 isoform X1

  2. XM_054348148.1 → XP_054204123.1  adhesion G-protein coupled receptor G7 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96K78.2 GenPept UniProtKB/Swiss-Prot:Q96K78

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous