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TRIM52 tripartite motif containing 52 [ Homo sapiens (human) ]

Gene ID: 84851, updated on 3-Apr-2024

Summary

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Official Symbol
TRIM52provided by HGNC
Official Full Name
tripartite motif containing 52provided by HGNC
Primary source
HGNC:HGNC:19024
See related
Ensembl:ENSG00000183718 MIM:619265; AllianceGenome:HGNC:19024
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF102
Summary
Enables transcription coactivator activity and ubiquitin protein ligase activity. Involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; and protein autoubiquitination. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lymph node (RPKM 9.5), spleen (RPKM 9.1) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
5q35.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (181249062..181261143, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (181809597..181821096, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (180682147..180688144, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene receptor for activated C kinase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23790 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23791 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23792 Neighboring gene small nucleolar RNA, C/D box 96A Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180672476-180673404 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180673405-180674331 Neighboring gene uncharacterized LOC101928649 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:180674332-180675259 Neighboring gene small nucleolar RNA, C/D box 95 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23794 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23795 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16798 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16799 Neighboring gene TRIM52 antisense RNA 1 (head to head) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180691856-180692474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180692475-180693092 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:180694171-180694740 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:180694741-180695310 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:180707611-180708313 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180711037-180711557 Neighboring gene RNA, U6 small nuclear 705, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A repetitive acidic region contributes to the extremely rapid degradation of the cell-context essential protein TRIM52. Hacker K, et al. Sci Rep, 2019 May 27. PMID 31133683, Free PMC Article
  2. TRIM52 regulates the proliferation and invasiveness of lung cancer cells via the Wnt/β‑catenin pathway. Mu X, et al. Oncol Rep, 2019 Jun. PMID 31002351
  3. TRIM52 plays an oncogenic role in ovarian cancer associated with NF-kB pathway. Yang W, et al. Cell Death Dis, 2018 Sep 5. PMID 30185771, Free PMC Article
  4. Tripartite Motif Containing 52 (TRIM52) Promotes Cell Proliferation in Hepatitis B Virus-Associated Hepatocellular Carcinoma. Zhang Y, et al. Med Sci Monit, 2017 Nov 1. PMID 29089476, Free PMC Article
  5. TRIM52 positively mediates NF-κB to promote the growth of human benign prostatic hyperplasia cells through affecting TRAF2 ubiquitination. Sun J, et al. Life Sci, 2020 Oct 15. PMID 32898524

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRIM52 knockdown inhibits proliferation, inflammatory responses and oxidative stress in IL-1beta-induced synovial fibroblasts to alleviate temporomandibular joint osteoarthritis.
    Title: TRIM52 knockdown inhibits proliferation, inflammatory responses and oxidative stress in IL-1β-induced synovial fibroblasts to alleviate temporomandibular joint osteoarthritis.
  2. Long non-coding RNA TRIM52-AS1 sponges microRNA-577 to facilitate diffuse large B cell lymphoma progression via increasing TRIM52 expression.
    Title: Long non-coding RNA TRIM52-AS1 sponges microRNA-577 to facilitate diffuse large B cell lymphoma progression via increasing TRIM52 expression.
  3. TRIM52 positively mediates NF-kappaB to promote the growth of human benign prostatic hyperplasia cells through affecting TRAF2 ubiquitination.
    Title: TRIM52 positively mediates NF-κB to promote the growth of human benign prostatic hyperplasia cells through affecting TRAF2 ubiquitination.
  4. A repetitive acidic region contributes to the extremely rapid degradation of the cell-context essential protein TRIM52.
    Title: A repetitive acidic region contributes to the extremely rapid degradation of the cell-context essential protein TRIM52.
  5. TRIM52 plays an oncogenic role in ovarian cancer development.
    Title: TRIM52 plays an oncogenic role in ovarian cancer associated with NF-kB pathway.
  6. Based on these data, it was speculated that TRIM52 is critical for lung cancer progression and that downregulation of TRIM52 could inhibit cell proliferation by blocking cell cycle progression.
    Title: TRIM52 regulates the proliferation and invasiveness of lung cancer cells via the Wnt/β‑catenin pathway.
  7. Our findings suggest that TRIM52 up-regulation promotes proliferation, migration and invasion of HCC cells through the ubiquitination of PPM1A.
    Title: TRIM52 up-regulation in hepatocellular carcinoma cells promotes proliferation, migration and invasion through the ubiquitination of PPM1A.
  8. TRIM52 can promote cell proliferation and HBx may regulate TRIM52 expression via the NF-kappaB signaling pathway in Hepatitis B Virus-Associated Hepatocellular Carcinoma.
    Title: Tripartite Motif Containing 52 (TRIM52) Promotes Cell Proliferation in Hepatitis B Virus-Associated Hepatocellular Carcinoma.
  9. these data suggested that TRIM52 was a positive regulator of the NF-kappaB pathway.
    Title: TRIM52: A nuclear TRIM protein that positively regulates the nuclear factor-kappa B signaling pathway.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC16175

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in defense response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein autoubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase TRIM52
Names
RING finger protein 102
tripartite motif-containing protein 52
NP_001332977.1
NP_001332978.1
NP_001332979.1
NP_001332980.1
NP_116154.1
XP_016865480.1
XP_054209680.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346048.2 → NP_001332977.1  E3 ubiquitin-protein ligase TRIM52 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC008443, KF510262
    Consensus CDS
    CCDS93844.1
    UniProtKB/TrEMBL
    A0A8I5KQM7, A0A8I5KXP2
    Related
    ENSP00000508553.1, ENST00000688015.1
    Conserved Domains (2) summary
    cd16602
    Location:16 → 48
    RING-HC_TRIM41_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM41, TRIM52 and similar proteins
    cd19762
    Location:225 → 268
    Bbox2_TRIM7-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM7, TRIM27 and similar proteins

  2. NM_001346049.2 → NP_001332978.1  E3 ubiquitin-protein ligase TRIM52 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC008443, KF510262
    Consensus CDS
    CCDS93843.1
    UniProtKB/TrEMBL
    A0A8I5KXP2, A0A8I5KYD8
    Related
    ENSP00000509812.1, ENST00000685507.1

  3. NM_001346050.2 → NP_001332979.1  E3 ubiquitin-protein ligase TRIM52 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC008443, KF510262
    Consensus CDS
    CCDS93846.1
    UniProtKB/TrEMBL
    A0A8I5KW90, A0A8I5KXP2
    Related
    ENSP00000510569.1, ENST00000686030.1

  4. NM_001346051.2 → NP_001332980.1  E3 ubiquitin-protein ligase TRIM52 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (5) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC008443, KF510262
    Consensus CDS
    CCDS93845.1
    UniProtKB/TrEMBL
    A0A8I5KRY2, A0A8I5KXP2
    Related
    ENSP00000509327.1, ENST00000510796.2

  5. NM_032765.4 → NP_116154.1  E3 ubiquitin-protein ligase TRIM52 isoform 1

    See identical proteins and their annotated locations for NP_116154.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA806088, AC008443, AK026706, BC007372
    Consensus CDS
    CCDS4467.1
    UniProtKB/Swiss-Prot
    L0CQ38, Q59G66, Q96A61
    UniProtKB/TrEMBL
    A0A8I5KXP2
    Related
    ENSP00000483005.1, ENST00000611618.1
    Conserved Domains (2) summary
    cd00021
    Location:226 → 263
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd16602
    Location:16 → 48
    RING-HC_TRIM41_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM41, TRIM52 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    181249062..181261143 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009991.3 → XP_016865480.1  E3 ubiquitin-protein ligase TRIM52 isoform X1

    UniProtKB/TrEMBL
    A0A8I5KXP2, A0A8I5KXQ2
    Related
    ENSP00000509065.1, ENST00000503005.2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    181809597..181821096 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054353705.1 → XP_054209680.1  E3 ubiquitin-protein ligase TRIM52 isoform X1

    UniProtKB/TrEMBL
    A0A8I5KXQ2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96A61.1 GenPept UniProtKB/Swiss-Prot:Q96A61

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