U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

FCRLA Fc receptor like A [ Homo sapiens (human) ]

Gene ID: 84824, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
FCRLAprovided by HGNC
Official Full Name
Fc receptor like Aprovided by HGNC
Primary source
HGNC:HGNC:18504
See related
Ensembl:ENSG00000132185 MIM:606891; AllianceGenome:HGNC:18504
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FCRL; FCRX; FREB; FCRL1; FCRLX; FCRLb; FCRLd; FCRLe; FCRLM1; FCRLc1; FCRLc2
Summary
This gene encodes a protein similar to receptors for the Fc fragment of gamma immunoglobulin (IgG). These receptors, referred to as FCGRs, mediate the destruction of IgG-coated antigens and of cells induced by antibodies. This encoded protein is selectively expressed in B cells, and may be involved in their development. This protein may also be involved in the development of lymphomas. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Expression
Biased expression in lymph node (RPKM 32.1), spleen (RPKM 21.2) and 3 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1q23.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (161707229..161714352)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (161051554..161058676)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161677019..161684142)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1483 Neighboring gene Fc gamma receptor IIb Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:161640790-161641368 Neighboring gene ribosomal protein L31 pseudogene 11 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1995 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1484 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1997 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1998 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1485 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1486 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1487 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1999 Neighboring gene Fc receptor like B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2000 Neighboring gene RNA, 7SL, cytoplasmic 466, pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Development and Validation of the B Cell-Associated Fc Receptor-like Molecule-Based Prognostic Signature in Skin Cutaneous Melanoma. Liu Y, et al. Biomed Res Int, 2020. PMID 32908921, Free PMC Article
  2. B cell-specific protein FCRLA is expressed by plasmacytoid dendritic cells in humans. Reshetnikova E, et al. Cytometry B Clin Cytom, 2018 Jul. PMID 29236355
  3. FCRLA-A Resident Endoplasmic Reticulum Protein that Associates with Multiple Immunoglobulin Isotypes in B Lineage Cells. Blackburn TE, et al. Curr Top Microbiol Immunol, 2017. PMID 28879521
  4. Characterization of human FCRLA isoforms. Kulemzin S, et al. Immunol Lett, 2013 May. PMID 23742757
  5. FCRLA is a resident endoplasmic reticulum protein that associates with intracellular Igs, IgM, IgG and IgA. Santiago T, et al. Int Immunol, 2011 Jan. PMID 21149418, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Development and Validation of the B Cell-Associated Fc Receptor-like Molecule-Based Prognostic Signature in Skin Cutaneous Melanoma.
    Title: Development and Validation of the B Cell-Associated Fc Receptor-like Molecule-Based Prognostic Signature in Skin Cutaneous Melanoma.
  2. FCRLA has long been viewed as a B cell specific protein, and this is the first time its expression has also been shown in human plasmacytoid dendritic cells
    Title: B cell-specific protein FCRLA is expressed by plasmacytoid dendritic cells in humans.
  3. FCRLA-A Resident Endoplasmic Reticulum Protein that Associates with Multiple Immunoglobulin Isotypes in B Lineage Cells
    Title: FCRLA-A Resident Endoplasmic Reticulum Protein that Associates with Multiple Immunoglobulin Isotypes in B Lineage Cells.
  4. This first genome-wide association approach for cyclophosphamide response in lupus nephritis patients yielded a robust profile of genetic associations including large-effect SNP in the FCGR2B-FCRLA locus, which may provide better insights to cyclophosphamide metabolism and efficacy.
    Title: Response to Intravenous Cyclophosphamide Treatment for Lupus Nephritis Associated with Polymorphisms in the FCGR2B-FCRLA Locus.
  5. FCGR2C SNPs that associated with vaccine efficacy in RV144 also strongly associated with the expression of FCGR2A/C and one of them also associated with the expression of Fc receptor-like A (FCRLA), another Fc-gamma receptor (FcgammaR) gene
    Title: FCGR2C Polymorphisms Associated with HIV-1 Vaccine Protection Are Linked to Altered Gene Expression of Fc-γ Receptors in Human B Cells.
  6. alternative splicing of FCRLA mRNA results in the production of isoforms differing by their domain composition and possessing either the short or long signal peptide.
    Title: Characterization of human FCRLA isoforms.
  7. The studies reported here demonstrate that FCRLA is more broadly expressed among human B lineage cells than originally reported; it is found at significant levels in resting blood B cells and at varying levels in all B-cell subsets in tonsil.
    Title: FCRLA is a resident endoplasmic reticulum protein that associates with intracellular Igs, IgM, IgG and IgA.
  8. Analysis of human cell lines has confirmed that FcRLA is not secreted but is maintained as an intracellular protein in B cells where it interacts with immunoglobulins.
    Title: Fc receptor-like A associates with intracellular IgG and IgM but is dispensable for antigen-specific immune responses.
  9. Observational study of gene-disease association. (HuGE Navigator)
    Title: New genetic associations detected in a host response study to hepatitis B vaccine.
  10. FCRL/FREB may function in melanocytes and melanoma and may be useful for development of diagnostic methods for various pigment disorders and immunotherapy of melanoma.
    Title: Novel melanoma antigen, FCRL/FREB, identified by cDNA profile comparison using DNA chip are immunogenic in multiple melanoma patients.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC4595

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Fc receptor-like A
Names
Fc receptor homolog expressed in B cells (FREB)
Fc receptor related protein X
Fc receptor-like and mucin-like 1
fc receptor homolog expressed in B-cells
fc receptor-like and mucin-like protein 1
fc receptor-like protein
fc receptor-related protein X

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001184866.2 → NP_001171795.2  Fc receptor-like A isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1). This variant has also been called FCRLa1.
    Source sequence(s)
    AL359541
    Consensus CDS
    CCDS53415.2
    Related
    ENSP00000356930.3, ENST00000367953.7
    Conserved Domains (2) summary
    pfam13895
    Location:177 → 266
    Ig_2; Immunoglobulin domain
    cl11960
    Location:85 → 152
    Ig; Immunoglobulin domain

  2. NM_001184867.2 → NP_001171796.2  Fc receptor-like A isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate, in-frame segments, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1. This variant has also been called FCRLb.
    Source sequence(s)
    AL359541
    Consensus CDS
    CCDS53417.2
    Related
    ENSP00000439838.1, ENST00000546024.5
    Conserved Domains (1) summary
    pfam13895
    Location:82 → 171
    Ig_2; Immunoglobulin domain

  3. NM_001184870.2 → NP_001171799.2  Fc receptor-like A isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate, in-frame segments, compared to variant 1. The resulting protein (isoform 4) is shorter when it is compared to isoform 1. This variant has also been called FCRLc1.
    Source sequence(s)
    AL359541
    Consensus CDS
    CCDS53416.2
    Related
    ENSP00000442870.1, ENST00000540521.5
    Conserved Domains (1) summary
    pfam13895
    Location:37 → 126
    Ig_2; Immunoglobulin domain

  4. NM_001184871.2 → NP_001171800.2  Fc receptor-like A isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks four alternate, in-frame segments, compared to variant 1. The resulting protein (isoform 7) is shorter when it is compared to isoform 1. This variant has also been called FCRLe.
    Source sequence(s)
    AL359541
    Consensus CDS
    CCDS53420.1
    Related
    ENSP00000344808.3, ENST00000350710.3

  5. NM_001184872.2 → NP_001171801.2  Fc receptor-like A isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks three alternate, in-frame segments, compared to variant 1. The resulting protein (isoform 5) is shorter when it is compared to isoform 1. This variant has also been called FCRLc2.
    Source sequence(s)
    AL359541
    Consensus CDS
    CCDS53419.2
    Related
    ENSP00000356934.3, ENST00000367957.7
    Conserved Domains (1) summary
    pfam13895
    Location:31 → 120
    Ig_2; Immunoglobulin domain

  6. NM_001184873.2 → NP_001171802.2  Fc receptor-like A isoform 6 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks three alternate, in-frame segments, compared to variant 1. The resulting protein (isoform 6) is shorter when it is compared to isoform 1. This variant has also been called FCRLd.
    Source sequence(s)
    AL359541
    Consensus CDS
    CCDS53418.1
    UniProtKB/TrEMBL
    Q5VXA5
    Related
    ENSP00000356926.2, ENST00000367949.6

  7. NM_001366195.2 → NP_001353124.2  Fc receptor-like A isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AL359541
    Conserved Domains (2) summary
    pfam13895
    Location:176 → 265
    Ig_2; Immunoglobulin domain
    cl11960
    Location:84 → 151
    Ig; Immunoglobulin domain

  8. NM_001366196.2 → NP_001353125.2  Fc receptor-like A isoform 9 precursor

    Status: REVIEWED

    Source sequence(s)
    AL359541
    Consensus CDS
    CCDS91091.1
    Related
    ENSP00000294798.7, ENST00000349527.8
    Conserved Domains (1) summary
    cl11960
    Location:79 → 146
    Ig; Immunoglobulin domain

  9. NM_032738.4 → NP_116127.4  Fc receptor-like A isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate, in-frame segment, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. This variant has also been called FCRLa.
    Source sequence(s)
    AL359541
    Consensus CDS
    CCDS30926.2
    UniProtKB/Swiss-Prot
    A0N0M1, A6NC03, A6NL20, F5H720, F8W743, G3V1J2, Q5VXA1, Q5VXA2, Q5VXA3, Q5VXA4, Q5VXB0, Q5VXB1, Q7L513, Q8NEW4, Q8WXH3, Q96PC6, Q96PJ0, Q96PJ1, Q96PJ2, Q96PJ4, Q9BR57
    Related
    ENSP00000236938.7, ENST00000236938.12
    Conserved Domains (2) summary
    pfam13895
    Location:171 → 260
    Ig_2; Immunoglobulin domain
    cl11960
    Location:79 → 146
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    161707229..161714352
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510065.2 → XP_011508367.2  Fc receptor-like A isoform X2

  2. XM_006711581.4 → XP_006711644.2  Fc receptor-like A isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    161051554..161058676
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339259.1 → XP_054195234.1  Fc receptor-like A isoform X2

  2. XM_054339258.1 → XP_054195233.1  Fc receptor-like A isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7L513.2 GenPept UniProtKB/Swiss-Prot:Q7L513

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous