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GPAT3 glycerol-3-phosphate acyltransferase 3 [ Homo sapiens (human) ]

Gene ID: 84803, updated on 5-Mar-2024

Summary

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Official Symbol
GPAT3provided by HGNC
Official Full Name
glycerol-3-phosphate acyltransferase 3provided by HGNC
Primary source
HGNC:HGNC:28157
See related
Ensembl:ENSG00000138678 MIM:610958; AllianceGenome:HGNC:28157
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAG1; AGPAT8; AGPAT9; AGPAT10; AGPAT 10; HMFN0839; LPAAT-theta
Summary
This gene encodes a member of the lysophosphatidic acid acyltransferase protein family. The encoded protein is an enzyme which catalyzes the conversion of glycerol-3-phosphate to lysophosphatidic acid in the synthesis of triacylglycerol. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012]
Expression
Broad expression in kidney (RPKM 23.1), duodenum (RPKM 10.2) and 14 other tissues See more
Orthologs
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Genomic context

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Location:
4q21.23
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (83535587..83605875)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (86865686..86935953)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (84457067..84527028)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15542 Neighboring gene solute carrier family 25 member 14 pseudogene 1 Neighboring gene abraxas 1, BRCA1 A complex subunit Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:84469077-84470276 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15543 Neighboring gene ribosomal protein L30 pseudogene 5 Neighboring gene Sharpr-MPRA regulatory region 7334 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:84539256-84540455 Neighboring gene Sharpr-MPRA regulatory region 4612 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:84557857-84558358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21689 Neighboring gene VISTA enhancer hs712 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:84702313-84703031 Neighboring gene uncharacterized LOC105377315 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:84771005-84771616 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:84771617-84772228 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:84775825-84777024 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:84843248-84843790 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:84843791-84844331 Neighboring gene NANOG hESC enhancer GRCh37_chr4:84917176-84917884 Neighboring gene long intergenic non-protein coding RNA 2994 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:85048206-85048769 Neighboring gene RNA, U6 small nuclear 774, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. GPAT3 regulates the synthesis of lipid intermediate LPA and exacerbates Kupffer cell inflammation mediated by the ERK signaling pathway. Fan G, et al. Cell Death Dis, 2023 Mar 24. PMID 36964139, Free PMC Article
  2. Metastasis-associated gene, mag-1 improves tumour microenvironmental adaptation and potentiates tumour metastasis. Wang Y, et al. J Cell Mol Med, 2012 Dec. PMID 22985252, Free PMC Article
  3. [Identification of novel metastasis associated genes MAG-1 and MAG-2]. Zhang J, et al. Zhongguo Fei Ai Za Zhi, 2003 Dec 20. PMID 21310131
  4. GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis. Shan D, et al. J Lipid Res, 2010 Jul. PMID 20181984, Free PMC Article
  5. Functional characterization of the human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 10/glycerol-3-phosphate acyltransferase isoform 3. Sukumaran S, et al. J Mol Endocrinol, 2009 Jun. PMID 19318427, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPAT3 regulates the synthesis of lipid intermediate LPA and exacerbates Kupffer cell inflammation mediated by the ERK signaling pathway.
    Title: GPAT3 regulates the synthesis of lipid intermediate LPA and exacerbates Kupffer cell inflammation mediated by the ERK signaling pathway.
  2. Oligomers of the lipodystrophy protein seipin may co-ordinate GPAT3 and AGPAT2 enzymes to facilitate adipocyte differentiation.
    Title: Oligomers of the lipodystrophy protein seipin may co-ordinate GPAT3 and AGPAT2 enzymes to facilitate adipocyte differentiation.
  3. Data show that 1-acylglycerol-3-phosphate O-acyltransferase 9 (AGPAT9) inhibit cell growth by regulating expression of KLF4/LASS2/V-ATPase proteins in breast cancer.
    Title: AGPAT9 suppresses cell growth, invasion and metastasis by counteracting acidic tumor microenvironment through KLF4/LASS2/V-ATPase signaling pathway in breast cancer.
  4. findings identified a direct role that mag-1 played in metastasis and implicated its function in cellular adaptation to tumour microenvironment
    Title: Metastasis-associated gene, mag-1 improves tumour microenvironmental adaptation and potentiates tumour metastasis.
  5. Results reveal a link between the lipogenic effects of insulin and microsomal GPAT3 and GPAT4, implying their importance in glycerolipid biosynthesis.
    Title: GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis.
  6. LPAAT-theta gene consisted of 12 exons and 11 introns, and mapped to chromosome 4q21.23, was ubiquitously expressed in 18 human tissues and overexpression of LPAAT-theta can induce mTOR-dependent p70S6K and 4EBP1 phosphorylation in HEK293T cells.
    Title: Identification of a novel human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC11324

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-acylglycerol-3-phosphate O-acyltransferase activity TAS
Traceable Author Statement
more info
  
NOT enables glycerol-3-phosphate O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycerol-3-phosphate O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CDP-diacylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol-3-phosphate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidic acid biosynthetic process TAS
Traceable Author Statement
more info
  
involved_in regulation of TOR signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in triglyceride biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in triglyceride biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
glycerol-3-phosphate acyltransferase 3
Names
1-AGP acyltransferase 9
1-AGPAT 9
1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10
1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9
1-acylglycerol-3-phosphate O-acyltransferase 8
1-acylglycerol-3-phosphate O-acyltransferase 9
GPAT-3
MAG-1
acyl-CoA:glycerol-3-phosphate acyltransferase 3
endoplasmic reticulum associated GPAT
hGPAT3
lung cancer metastasis-associated protein 1
lysophosphatidic acid acyltransferase theta
testis secretory sperm-binding protein Li 213e
NP_001243350.1
NP_001243351.1
NP_116106.2
XP_011530686.1
XP_016864269.1
XP_016864270.1
XP_054207093.1
XP_054207094.1
XP_054207095.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256421.1 → NP_001243350.1  glycerol-3-phosphate acyltransferase 3

    See identical proteins and their annotated locations for NP_001243350.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC021192, AC096768, AK055749, BM841009
    Consensus CDS
    CCDS3606.1
    UniProtKB/Swiss-Prot
    Q53EU6, Q68CJ4, Q6GPI6, Q96NA3
    UniProtKB/TrEMBL
    A0A024RDG5, A0A140VK86
    Related
    ENSP00000378651.2, ENST00000395226.6
    Conserved Domains (1) summary
    cd07991
    Location:199 → 408
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

  2. NM_001256422.1 → NP_001243351.1  glycerol-3-phosphate acyltransferase 3

    See identical proteins and their annotated locations for NP_001243351.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC021192, BM841009, DA393801
    Consensus CDS
    CCDS3606.1
    UniProtKB/Swiss-Prot
    Q53EU6, Q68CJ4, Q6GPI6, Q96NA3
    UniProtKB/TrEMBL
    A0A024RDG5, A0A140VK86
    Related
    ENSP00000482571.1, ENST00000611707.4
    Conserved Domains (1) summary
    cd07991
    Location:199 → 408
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

  3. NM_032717.5 → NP_116106.2  glycerol-3-phosphate acyltransferase 3

    See identical proteins and their annotated locations for NP_116106.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC096768, AY358100, BM841009, DA673378
    Consensus CDS
    CCDS3606.1
    UniProtKB/Swiss-Prot
    Q53EU6, Q68CJ4, Q6GPI6, Q96NA3
    UniProtKB/TrEMBL
    A0A024RDG5, A0A140VK86
    Related
    ENSP00000264409.4, ENST00000264409.5
    Conserved Domains (1) summary
    cd07991
    Location:199 → 408
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    83535587..83605875
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008780.2 → XP_016864269.1  glycerol-3-phosphate acyltransferase 3 isoform X1

  2. XM_017008781.2 → XP_016864270.1  glycerol-3-phosphate acyltransferase 3 isoform X2

    UniProtKB/Swiss-Prot
    Q53EU6, Q68CJ4, Q6GPI6, Q96NA3
    UniProtKB/TrEMBL
    A0A024RDG5, A0A140VK86
    Conserved Domains (1) summary
    cd07991
    Location:199 → 408
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

  3. XM_011532384.3 → XP_011530686.1  glycerol-3-phosphate acyltransferase 3 isoform X3

    See identical proteins and their annotated locations for XP_011530686.1

    Conserved Domains (1) summary
    cd07991
    Location:121 → 330
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    86865686..86935953
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054351118.1 → XP_054207093.1  glycerol-3-phosphate acyltransferase 3 isoform X1

  2. XM_054351119.1 → XP_054207094.1  glycerol-3-phosphate acyltransferase 3 isoform X2

    UniProtKB/Swiss-Prot
    Q53EU6, Q68CJ4, Q6GPI6, Q96NA3
    UniProtKB/TrEMBL
    A0A024RDG5, A0A140VK86

  3. XM_054351120.1 → XP_054207095.1  glycerol-3-phosphate acyltransferase 3 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q53EU6.2 GenPept UniProtKB/Swiss-Prot:Q53EU6

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