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NAA11 N-alpha-acetyltransferase 11, NatA catalytic subunit [ Homo sapiens (human) ]

Gene ID: 84779, updated on 5-Mar-2024

Summary

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Official Symbol
NAA11provided by HGNC
Official Full Name
N-alpha-acetyltransferase 11, NatA catalytic subunitprovided by HGNC
Primary source
HGNC:HGNC:28125
See related
Ensembl:ENSG00000156269 MIM:619432; AllianceGenome:HGNC:28125
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARD2; ARD1B; hARD2
Summary
Enables peptide alpha-N-acetyltransferase activity. Involved in N-terminal protein amino acid acetylation. Located in several cellular components, including Golgi apparatus; centrosome; and nucleoplasm. Part of NatA complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 1.1) and placenta (RPKM 0.8) See more
Orthologs
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Genomic context

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Location:
4q21.21
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (79155376..79326061, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (82491029..82661846, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (80237801..80247215, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene BMP2 inducible kinase Neighboring gene RNA, 7SL, cytoplasmic 127, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15514 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15515 Neighboring gene progestin and adipoQ receptor family member 3 Neighboring gene long intergenic non-protein coding RNA 1088 Neighboring gene uncharacterized LOC124900723 Neighboring gene MPRA-validated peak5059 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:80169419-80169920 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:80218690-80219258 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:80274106-80274606 Neighboring gene uncharacterized LOC105377300 Neighboring gene glycerol kinase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Up-regulation of human arrest-defective 1 protein is correlated with metastatic phenotype and poor prognosis in breast cancer. Wang ZH, et al. Asian Pac J Cancer Prev, 2011. PMID 22292636
  2. Expression of human NAA11 (ARD1B) gene is tissue-specific and is regulated by DNA methylation. Pang AL, et al. Epigenetics, 2011 Nov. PMID 22048246, Free PMC Article
  3. LOH analysis of genes around D4S2964 identifies ARD1B as a prognostic predictor of hepatocellular carcinoma. Huang GL, et al. World J Gastroenterol, 2010 Apr 28. PMID 20419844, Free PMC Article
  4. Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase. Arnesen T, et al. BMC Biochem, 2006 Apr 25. PMID 16638120, Free PMC Article
  5. A novel human NatA Nalpha-terminal acetyltransferase complex: hNaa16p-hNaa10p (hNat2-hArd1). Arnesen T, et al. BMC Biochem, 2009 May 29. PMID 19480662, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NAA11 expression is tissue-specific and is epigenetically regulated by DNA methylation.
    Title: Expression of human NAA11 (ARD1B) gene is tissue-specific and is regulated by DNA methylation.
  2. ARD1 protein was observed at 61.0% (50/82), 54.7% (87/159), 37.9% (25/66), 36.8% (7/19) in IDC, fibroadenoma, hyperplasia, and inflammation, respectively.
    Title: Up-regulation of human arrest-defective 1 protein is correlated with metastatic phenotype and poor prognosis in breast cancer.
  3. LOH in genes around D4S2964, including ARD1B and SEPT11 may play an important role in hepatocellular carcinoma development and progression
    Title: LOH analysis of genes around D4S2964 identifies ARD1B as a prognostic predictor of hepatocellular carcinoma.
  4. hARD2, an N-alpha-acetyltransferase has 81 % sequence identity to hARD1. Its gene may originate from a eutherian-mammal-specific retrotransposition event. hARD2-NATH complexes may be responsible for protein N-alpha-acetylation in human cells.
    Title: Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase.
  5. hARD2 (MGC10646) is a novel human protein N-alpha acetyltransferase
    Title: Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC10646

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables peptide alpha-N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptide-glutamate-alpha-N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide-serine-alpha-N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in N-terminal protein amino acid acetylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
part_of NatA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NatA complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of NatA complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
  
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
N-alpha-acetyltransferase 11
Names
=N-terminal acetyltransferase complex ARD1 subunit homolog B
ARD1 homolog B
N-terminal acetyltransferase complex ARD1 subunit homolog B
human arrest defective 2
natA catalytic subunit Naa11
NP_116082.1
XP_016864266.1
XP_016864267.1
XP_016864268.1
XP_054207090.1
XP_054207091.1
XP_054207092.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032693.3 → NP_116082.1  N-alpha-acetyltransferase 11

    See identical proteins and their annotated locations for NP_116082.1

    Status: VALIDATED

    Source sequence(s)
    AC023277, BC004552
    Consensus CDS
    CCDS47084.1
    UniProtKB/Swiss-Prot
    Q66K19, Q6P479, Q9BSU3
    Related
    ENSP00000286794.4, ENST00000286794.5
    Conserved Domains (2) summary
    COG0456
    Location:1 → 149
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
    pfam00583
    Location:47 → 122
    Acetyltransf_1; Acetyltransferase (GNAT) family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    79155376..79326061 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008779.2 → XP_016864268.1  N-alpha-acetyltransferase 11 isoform X1

    UniProtKB/Swiss-Prot
    Q66K19, Q6P479, Q9BSU3
    Conserved Domains (2) summary
    COG0456
    Location:1 → 149
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
    pfam00583
    Location:47 → 122
    Acetyltransf_1; Acetyltransferase (GNAT) family

  2. XM_017008778.3 → XP_016864267.1  N-alpha-acetyltransferase 11 isoform X1

    UniProtKB/Swiss-Prot
    Q66K19, Q6P479, Q9BSU3
    Conserved Domains (2) summary
    COG0456
    Location:1 → 149
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
    pfam00583
    Location:47 → 122
    Acetyltransf_1; Acetyltransferase (GNAT) family

  3. XM_017008777.2 → XP_016864266.1  N-alpha-acetyltransferase 11 isoform X1

    UniProtKB/Swiss-Prot
    Q66K19, Q6P479, Q9BSU3
    Conserved Domains (2) summary
    COG0456
    Location:1 → 149
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
    pfam00583
    Location:47 → 122
    Acetyltransf_1; Acetyltransferase (GNAT) family

RNA

  1. XR_007057978.1 RNA Sequence

  2. XR_001741340.2 RNA Sequence

  3. XR_001741339.2 RNA Sequence

  4. XR_007057977.1 RNA Sequence

  5. XR_007057979.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    82491029..82661846 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054351117.1 → XP_054207092.1  N-alpha-acetyltransferase 11 isoform X1

    UniProtKB/Swiss-Prot
    Q66K19, Q6P479, Q9BSU3

  2. XM_054351116.1 → XP_054207091.1  N-alpha-acetyltransferase 11 isoform X1

    UniProtKB/Swiss-Prot
    Q66K19, Q6P479, Q9BSU3

  3. XM_054351115.1 → XP_054207090.1  N-alpha-acetyltransferase 11 isoform X1

    UniProtKB/Swiss-Prot
    Q66K19, Q6P479, Q9BSU3

RNA

  1. XR_008487051.1 RNA Sequence

  2. XR_008487050.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BSU3.3 GenPept UniProtKB/Swiss-Prot:Q9BSU3

Gene LinkOut

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