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ZNF607 zinc finger protein 607 [ Homo sapiens (human) ]

Gene ID: 84775, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF607provided by HGNC
Official Full Name
zinc finger protein 607provided by HGNC
Primary source
HGNC:HGNC:28192
See related
Ensembl:ENSG00000198182 AllianceGenome:HGNC:28192
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 3.1), thyroid (RPKM 2.6) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF607 in Genome Data Viewer
Location:
19q13.12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (37696363..37719761, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (40498113..40521515, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (38187264..38210662, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 781 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38186077-38186752 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:38187429-38188103 Neighboring gene selenoprotein K pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10557 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10558 Neighboring gene zinc finger protein 573 Neighboring gene H3K27ac hESC enhancers GRCh37_chr19:38269714-38270377 and GRCh37_chr19:38270378-38271040 Neighboring gene uncharacterized LOC105372394 Neighboring gene IST1 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ΔNp63α Suppresses TGFB2 Expression and RHOA Activity to Drive Cell Proliferation in Squamous Cell Carcinomas. Abraham CG, et al. Cell Rep, 2018 Sep 18. PMID 30232004, Free PMC Article
  2. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. Oguri M, et al. Am J Hypertens, 2010 Jan. PMID 19851296
  3. Association of genetic variants with hemorrhagic stroke in Japanese individuals. Yoshida T, et al. Int J Mol Med, 2010 Apr. PMID 20198315
  4. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. Xiao T, et al. Proc Natl Acad Sci U S A, 2018 Jul 31. PMID 29987050, Free PMC Article
  5. Next-generation sequencing to generate interactome datasets. Yu H, et al. Nat Methods, 2011 Jun. PMID 21516116, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association of genetic variants with hemorrhagic stroke in Japanese individuals.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ14802, MGC13071

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 607

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172677.1 → NP_001166148.1  zinc finger protein 607 isoform 2

    See identical proteins and their annotated locations for NP_001166148.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 1. The resulting isoform (2) lacks one internal amino acid, compared to isoform 1.
    Source sequence(s)
    AC093227
    Consensus CDS
    CCDS54259.1
    UniProtKB/Swiss-Prot
    Q96SK3
    Related
    ENSP00000438015.1, ENST00000395835.7
    Conserved Domains (3) summary
    smart00349
    Location:7 → 66
    KRAB; krueppel associated box
    COG5048
    Location:222 → 618
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:450 → 470
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001375895.1 → NP_001362824.1  zinc finger protein 607 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC093227
    Consensus CDS
    CCDS54259.1
    Conserved Domains (3) summary
    smart00349
    Location:7 → 66
    KRAB; krueppel associated box
    COG5048
    Location:222 → 618
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:450 → 470
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_032689.5 → NP_116078.4  zinc finger protein 607 isoform 1

    See identical proteins and their annotated locations for NP_116078.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC093227
    Consensus CDS
    CCDS33006.1
    UniProtKB/Swiss-Prot
    F5H141, Q6ZMN2, Q6ZMN4, Q96C40, Q96SK3
    Related
    ENSP00000347338.2, ENST00000355202.9
    Conserved Domains (5) summary
    smart00349
    Location:7 → 67
    KRAB; krueppel associated box
    COG5048
    Location:279 → 687
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:451 → 471
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 45
    KRAB; KRAB box
    pfam13465
    Location:407 → 432
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    37696363..37719761 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439553.1 → XP_047295509.1  zinc finger protein 607 isoform X2

  2. XM_047439552.1 → XP_047295508.1  zinc finger protein 607 isoform X2

  3. XM_006723435.5 → XP_006723498.1  zinc finger protein 607 isoform X1

    See identical proteins and their annotated locations for XP_006723498.1

    UniProtKB/Swiss-Prot
    F5H141, Q6ZMN2, Q6ZMN4, Q96C40, Q96SK3
    Conserved Domains (5) summary
    smart00349
    Location:7 → 67
    KRAB; krueppel associated box
    COG5048
    Location:279 → 687
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:451 → 471
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 45
    KRAB; KRAB box
    pfam13465
    Location:407 → 432
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    40498113..40521515 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322408.1 → XP_054178383.1  zinc finger protein 607 isoform X2

  2. XM_054322407.1 → XP_054178382.1  zinc finger protein 607 isoform X2

  3. XM_054322406.1 → XP_054178381.1  zinc finger protein 607 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96SK3.3 GenPept UniProtKB/Swiss-Prot:Q96SK3

Gene LinkOut

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