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CDC42BPA CDC42 binding protein kinase alpha [ Homo sapiens (human) ]

Gene ID: 8476, updated on 14-Nov-2024

Summary

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Official Symbol
CDC42BPAprovided by HGNC
Official Full Name
CDC42 binding protein kinase alphaprovided by HGNC
Primary source
HGNC:HGNC:1737
See related
Ensembl:ENSG00000143776 MIM:603412; AllianceGenome:HGNC:1737
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRCK; MRCKA; PK428; MRCKalpha
Summary
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2018]
Expression
Ubiquitous expression in testis (RPKM 11.8), kidney (RPKM 9.4) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See CDC42BPA in Genome Data Viewer
Location:
1q42.13
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (226989858..227318492, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (226178223..226506850, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (227177559..227506193, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985354 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:227126665-227127356 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1895 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:227138969-227139468 Neighboring gene MPRA-validated peak738 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:227161529-227162142 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:227166346-227167094 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:227172247-227172425 Neighboring gene coenzyme Q8A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2676 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:227180293-227181492 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:227182370-227182516 Neighboring gene NANOG hESC enhancer GRCh37_chr1:227259898-227260481 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:227309525-227309674 Neighboring gene MPRA-validated peak741 silencer Neighboring gene cathepsin B pseudogene Neighboring gene phosphatidylinositol 4-kinase type 2 beta pseudogene Neighboring gene UBA5 pseudogene 1 Neighboring gene uncharacterized LOC124904531 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:227543671-227544356 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:227544357-227545040 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:227576538-227577298 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:227583939-227585138 Neighboring gene long intergenic non-protein coding RNA 1641 Neighboring gene nuclear casein kinase and cyclin dependent kinase substrate 1 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Gene transfer of MRCKα rescues lipopolysaccharide-induced acute lung injury by restoring alveolar capillary barrier function. Liu J, et al. Sci Rep, 2021 Oct 21. PMID 34675326, Free PMC Article
  2. Evidence for a role of MRCK in mediating HeLa cell elongation induced by the C1 domain ligand HMI-1a3. Talman V, et al. Eur J Pharm Sci, 2014 May 13. PMID 24486483
  3. A novel iron responsive element in the 3'UTR of human MRCKalpha. Cmejla R, et al. Biochem Biophys Res Commun, 2006 Mar 3. PMID 16412980
  4. Genomic organization of human myotonic dystrophy kinase-related Cdc42-binding kinase alpha reveals multiple alternative splicing and functional diversity. Tan I, et al. Gene, 2003 Jan 30. PMID 12568720
  5. Cdc42 antagonizes inductive action of cAMP on cell shape, via effects of the myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) on myosin light chain phosphorylation. Dong JM, et al. Eur J Cell Biol, 2002 Apr. PMID 12018391

See all (99) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tumor-associated macrophage-induced circMRCKalpha encodes a peptide to promote glycolysis and progression in hepatocellular carcinoma.
    Title: Tumor-associated macrophage-induced circMRCKα encodes a peptide to promote glycolysis and progression in hepatocellular carcinoma.
  2. MRCK-Alpha and Its Effector Myosin II Regulatory Light Chain Bind ABCB4 and Regulate Its Membrane Expression.
    Title: MRCK-Alpha and Its Effector Myosin II Regulatory Light Chain Bind ABCB4 and Regulate Its Membrane Expression.
  3. Gene transfer of MRCKalpha rescues lipopolysaccharide-induced acute lung injury by restoring alveolar capillary barrier function.
    Title: Gene transfer of MRCKα rescues lipopolysaccharide-induced acute lung injury by restoring alveolar capillary barrier function.
  4. Effect and in silico characterization of genetic variants associated with severe spermatogenic disorders in a large Iberian cohort.
    Title: Effect and in silico characterization of genetic variants associated with severe spermatogenic disorders in a large Iberian cohort.
  5. Myotonic dystrophy kinase-related CDC42-binding kinase alpha, a new transferrin receptor type 2-binding partner, is a regulator of erythropoiesis.
    Title: Myotonic dystrophy kinase-related CDC42-binding kinase α, a new transferrin receptor type 2-binding partner, is a regulator of erythropoiesis.
  6. The Na+, K+-ATPase beta1 subunit regulates epithelial tight junctions via MRCKalpha.
    Title: The Na+, K+-ATPase β1 subunit regulates epithelial tight junctions via MRCKα.
  7. Functional proteomics interrogation of the kinome identifies MRCKA as a therapeutic target in high-grade serous ovarian carcinoma.
    Title: Functional proteomics interrogation of the kinome identifies MRCKA as a therapeutic target in high-grade serous ovarian carcinoma.
  8. The authors describe the discovery of MRCKalpha as a downstream effector of apoptosis and trigger of epithelial extrusion. By describing this novel role of MRCKalpha during apoptosis, the authors cast light on the complex actomyosin cytoskeleton dynamics in the process of epithelial cell extrusion and, likely, in the homeostatic maintenance of tissues in multicellular organisms.
    Title: MRCKα is activated by caspase cleavage to assemble an apical actin ring for epithelial cell extrusion.
  9. Cdc42BPA and Cdc42 signaling are important for colon cancer invasion, and Cdc42BPA has potential implications for colon cancer prognosis and treatment.
    Title: Comparative Proteomics Analysis Identifies Cdc42-Cdc42BPA Signaling as Prognostic Biomarker and Therapeutic Target for Colon Cancer Invasion.
  10. Silencing of CDC42BPA expression partially reduces miR29a3p inhibitor-induced migration and invasion of SW4807 cells
    Title: Inhibition of cell migration and invasion by miR‑29a‑3p in a colorectal cancer cell line through suppression of CDC42BPA mRNA expression.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23347, KIAA0451, DKFZp686L1738, DKFZp686P1738

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actomyosin structure organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actomyosin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actomyosin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell leading edge ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cell-cell junction ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase MRCK alpha
Names
CDC42 binding protein kinase alpha (DMPK-like)
CDC42 binding protein kinase beta
myotonic dystrophy kinase-related CDC42-binding protein kinase alpha
myotonic dystrophy protein kinase-like alpha
ser-thr protein kinase PK428
ser-thr protein kinase related to the myotonic dystrophy protein kinase
NP_001352939.1
NP_001352940.1
NP_001352948.1
NP_001374479.1
NP_001380943.1
NP_003598.2
NP_055641.3
XP_005273374.1
XP_005273375.1
XP_005273377.1
XP_005273378.1
XP_006711897.1
XP_006711898.1
XP_011542609.1
XP_011542610.1
XP_011542611.1
XP_016858067.1
XP_016858069.1
XP_016858071.1
XP_047288302.1
XP_047288313.1
XP_047288320.1
XP_047288321.1
XP_047288323.1
XP_047288334.1
XP_054195215.1
XP_054195216.1
XP_054195217.1
XP_054195218.1
XP_054195219.1
XP_054195220.1
XP_054195221.1
XP_054195222.1
XP_054195223.1
XP_054195224.1
XP_054195225.1
XP_054195226.1
XP_054195227.1
XP_054195228.1
XP_054195229.1
XP_054195230.1
XP_054195231.1
XP_054195232.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001366010.2 → NP_001352939.1  serine/threonine-protein kinase MRCK alpha isoform D

    Status: REVIEWED

    Source sequence(s)
    AB208968, AL353689, AL627308, BC136333
    UniProtKB/TrEMBL
    B9EGA7
    Conserved Domains (7) summary
    smart00285
    Location:1530 → 1564
    PBD; P21-Rho-binding domain
    COG0419
    Location:442 → 979
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00029
    Location:972 → 1021
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01243
    Location:1031 → 1165
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:1191 → 1455
    CNH; CNH domain
    pfam15796
    Location:530 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

  2. NM_001366011.1 → NP_001352940.1  serine/threonine-protein kinase MRCK alpha isoform E

    Status: REVIEWED

    Source sequence(s)
    AL353689, AL627308, BC136333
    Consensus CDS
    CCDS91168.1
    UniProtKB/TrEMBL
    A0A0A0MRJ0, B9EGA7
    Related
    ENSP00000355726.5, ENST00000366764.8
    Conserved Domains (7) summary
    smart00285
    Location:1538 → 1572
    PBD; P21-Rho-binding domain
    COG0419
    Location:442 → 944
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00029
    Location:980 → 1029
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01243
    Location:1039 → 1173
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:1199 → 1463
    CNH; CNH domain
    pfam15796
    Location:530 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

  3. NM_001366019.2 → NP_001352948.1  serine/threonine-protein kinase MRCK alpha isoform C

    Status: REVIEWED

    Source sequence(s)
    AL353689, AL451047, AL627308
    Consensus CDS
    CCDS91170.1
    UniProtKB/Swiss-Prot
    O75039, Q59GZ1, Q5H9N9, Q5T797, Q5VT25, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646
    UniProtKB/TrEMBL
    B9EGA7
    Related
    ENSP00000335341.6, ENST00000334218.9
    Conserved Domains (6) summary
    COG0419
    Location:432 → 941
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00029
    Location:1013 → 1062
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01243
    Location:1072 → 1206
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:1232 → 1496
    CNH; CNH domain
    pfam15796
    Location:530 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

  4. NM_001387550.1 → NP_001374479.1  serine/threonine-protein kinase MRCK alpha isoform F

    Status: REVIEWED

    Source sequence(s)
    AL353689, AL451047, AL627308
    UniProtKB/TrEMBL
    A0A0A0MRJ1, B9EGA7
    Conserved Domains (6) summary
    COG0419
    Location:432 → 941
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1123 → 1257
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:1283 → 1547
    CNH; CNH domain
    pfam15796
    Location:530 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    cd20864
    Location:1062 → 1121
    C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins

  5. NM_001394014.1 → NP_001380943.1  serine/threonine-protein kinase MRCK alpha isoform G

    Status: REVIEWED

    Source sequence(s)
    AL353689, AL451047, AL627308
    Consensus CDS
    CCDS91169.1
    UniProtKB/TrEMBL
    B9EGA7
    Related
    ENSP00000355728.5, ENST00000366766.8
    Conserved Domains (6) summary
    COG0419
    Location:432 → 941
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:1094 → 1228
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:1254 → 1518
    CNH; CNH domain
    pfam15796
    Location:530 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    cd20864
    Location:1033 → 1092
    C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins

  6. NM_003607.4 → NP_003598.2  serine/threonine-protein kinase MRCK alpha isoform B

    See identical proteins and their annotated locations for NP_003598.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (B) encodes the longer isoform (B).
    Source sequence(s)
    AJ518975, AL353689, AL627308, BC050335, BF765241, BQ232716, BX648219
    Consensus CDS
    CCDS1558.1
    UniProtKB/TrEMBL
    B9EGA7
    Related
    ENSP00000355731.3, ENST00000366769.7
    Conserved Domains (8) summary
    pfam08826
    Location:881 → 941
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77 → 343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:481 → 791
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00029
    Location:1000 → 1049
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01243
    Location:1059 → 1193
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:1219 → 1483
    CNH; CNH domain
    pfam15796
    Location:530 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

  7. NM_014826.5 → NP_055641.3  serine/threonine-protein kinase MRCK alpha isoform A

    See identical proteins and their annotated locations for NP_055641.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A) lacks a coding segment compared to variant B, resulting in an isoform (A) that lacks an internal region, as compared to isoform B.
    Source sequence(s)
    AJ518976, AL353689, AL627308, BC050335, BF765241, BQ232716, BX648219
    Consensus CDS
    CCDS1559.1
    UniProtKB/TrEMBL
    Q8IWQ7
    Related
    ENSP00000355729.3, ENST00000366767.7
    Conserved Domains (7) summary
    pfam08826
    Location:800 → 860
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77 → 343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00029
    Location:919 → 968
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01243
    Location:978 → 1112
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:1138 → 1402
    CNH; CNH domain
    pfam15619
    Location:447 → 614
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    226989858..227318492 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002580.3 → XP_016858069.1  serine/threonine-protein kinase MRCK alpha isoform X11

    UniProtKB/TrEMBL
    B9EGA7

  2. XM_047432364.1 → XP_047288320.1  serine/threonine-protein kinase MRCK alpha isoform X13

  3. XM_047432365.1 → XP_047288321.1  serine/threonine-protein kinase MRCK alpha isoform X14

  4. XM_011544309.4 → XP_011542611.1  serine/threonine-protein kinase MRCK alpha isoform X10

    UniProtKB/TrEMBL
    Q8IWQ7
    Conserved Domains (7) summary
    pfam08826
    Location:800 → 860
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77 → 343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00029
    Location:983 → 1032
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01243
    Location:1042 → 1176
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:1202 → 1466
    CNH; CNH domain
    pfam15619
    Location:447 → 614
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease

  5. XM_005273321.5 → XP_005273378.1  serine/threonine-protein kinase MRCK alpha isoform X8

    UniProtKB/TrEMBL
    B9EGA7
    Conserved Domains (8) summary
    pfam08826
    Location:881 → 941
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77 → 343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:481 → 791
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00029
    Location:1000 → 1049
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01243
    Location:1059 → 1193
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:1219 → 1483
    CNH; CNH domain
    pfam15796
    Location:530 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

  6. XM_006711834.5 → XP_006711897.1  serine/threonine-protein kinase MRCK alpha isoform X3

    UniProtKB/TrEMBL
    B9EGA7
    Conserved Domains (8) summary
    pfam08826
    Location:881 → 941
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77 → 343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:481 → 791
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00029
    Location:1035 → 1084
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01243
    Location:1094 → 1228
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:1254 → 1518
    CNH; CNH domain
    pfam15796
    Location:530 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

  7. XM_005273320.5 → XP_005273377.1  serine/threonine-protein kinase MRCK alpha isoform X6

    UniProtKB/TrEMBL
    B9EGA7
    Conserved Domains (8) summary
    pfam08826
    Location:881 → 941
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77 → 343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:481 → 791
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00029
    Location:1013 → 1062
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01243
    Location:1072 → 1206
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:1232 → 1496
    CNH; CNH domain
    pfam15796
    Location:530 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

  8. XM_017002578.3 → XP_016858067.1  serine/threonine-protein kinase MRCK alpha isoform X9

    UniProtKB/TrEMBL
    B9EGA7

  9. XM_005273318.5 → XP_005273375.1  serine/threonine-protein kinase MRCK alpha isoform X2

    UniProtKB/TrEMBL
    B9EGA7
    Conserved Domains (8) summary
    pfam08826
    Location:881 → 941
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77 → 343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:481 → 791
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00029
    Location:1048 → 1097
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01243
    Location:1107 → 1241
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:1267 → 1531
    CNH; CNH domain
    pfam15796
    Location:530 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

  10. XM_047432357.1 → XP_047288313.1  serine/threonine-protein kinase MRCK alpha isoform X12

  11. XM_006711835.5 → XP_006711898.1  serine/threonine-protein kinase MRCK alpha isoform X5

    UniProtKB/TrEMBL
    B9EGA7
    Conserved Domains (8) summary
    pfam08826
    Location:881 → 941
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77 → 343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:481 → 791
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00029
    Location:1016 → 1065
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01243
    Location:1075 → 1209
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:1235 → 1499
    CNH; CNH domain
    pfam15796
    Location:530 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

  12. XM_005273317.5 → XP_005273374.1  serine/threonine-protein kinase MRCK alpha isoform X1

    UniProtKB/TrEMBL
    B9EGA7
    Conserved Domains (8) summary
    pfam08826
    Location:881 → 941
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77 → 343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:481 → 791
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00029
    Location:1051 → 1100
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01243
    Location:1110 → 1244
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:1270 → 1534
    CNH; CNH domain
    pfam15796
    Location:530 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

  13. XM_011544307.4 → XP_011542609.1  serine/threonine-protein kinase MRCK alpha isoform X4

    UniProtKB/TrEMBL
    B9EGA7
    Conserved Domains (8) summary
    pfam08826
    Location:881 → 941
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77 → 343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:481 → 791
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00029
    Location:1029 → 1078
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01243
    Location:1088 → 1222
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:1248 → 1512
    CNH; CNH domain
    pfam15796
    Location:530 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

  14. XM_011544308.4 → XP_011542610.1  serine/threonine-protein kinase MRCK alpha isoform X7

    UniProtKB/TrEMBL
    B9EGA7
    Conserved Domains (8) summary
    pfam08826
    Location:881 → 941
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77 → 343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:481 → 791
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd01243
    Location:1123 → 1257
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4 → 412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:1064 → 1114
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:1283 → 1547
    CNH; CNH domain
    pfam15796
    Location:530 → 608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

  15. XM_047432346.1 → XP_047288302.1  serine/threonine-protein kinase MRCK alpha isoform X11

  16. XM_047432378.1 → XP_047288334.1  serine/threonine-protein kinase MRCK alpha isoform X17

  17. XM_017002582.3 → XP_016858071.1  serine/threonine-protein kinase MRCK alpha isoform X16

    UniProtKB/TrEMBL
    B9EGA7

  18. XM_047432367.1 → XP_047288323.1  serine/threonine-protein kinase MRCK alpha isoform X15

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    226178223..226506850 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339251.1 → XP_054195226.1  serine/threonine-protein kinase MRCK alpha isoform X11

  2. XM_054339253.1 → XP_054195228.1  serine/threonine-protein kinase MRCK alpha isoform X13

  3. XM_054339254.1 → XP_054195229.1  serine/threonine-protein kinase MRCK alpha isoform X14

  4. XM_054339249.1 → XP_054195224.1  serine/threonine-protein kinase MRCK alpha isoform X10

  5. XM_054339247.1 → XP_054195222.1  serine/threonine-protein kinase MRCK alpha isoform X8

  6. XM_054339242.1 → XP_054195217.1  serine/threonine-protein kinase MRCK alpha isoform X3

  7. XM_054339245.1 → XP_054195220.1  serine/threonine-protein kinase MRCK alpha isoform X6

  8. XM_054339248.1 → XP_054195223.1  serine/threonine-protein kinase MRCK alpha isoform X9

  9. XM_054339241.1 → XP_054195216.1  serine/threonine-protein kinase MRCK alpha isoform X2

  10. XM_054339252.1 → XP_054195227.1  serine/threonine-protein kinase MRCK alpha isoform X12

  11. XM_054339244.1 → XP_054195219.1  serine/threonine-protein kinase MRCK alpha isoform X5

  12. XM_054339240.1 → XP_054195215.1  serine/threonine-protein kinase MRCK alpha isoform X1

  13. XM_054339243.1 → XP_054195218.1  serine/threonine-protein kinase MRCK alpha isoform X4

  14. XM_054339246.1 → XP_054195221.1  serine/threonine-protein kinase MRCK alpha isoform X7

  15. XM_054339250.1 → XP_054195225.1  serine/threonine-protein kinase MRCK alpha isoform X11

  16. XM_054339257.1 → XP_054195232.1  serine/threonine-protein kinase MRCK alpha isoform X17

  17. XM_054339256.1 → XP_054195231.1  serine/threonine-protein kinase MRCK alpha isoform X16

  18. XM_054339255.1 → XP_054195230.1  serine/threonine-protein kinase MRCK alpha isoform X15

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5VT25.1 GenPept UniProtKB/Swiss-Prot:Q5VT25

Gene LinkOut

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