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SORBS2 sorbin and SH3 domain containing 2 [ Homo sapiens (human) ]

Gene ID: 8470, updated on 5-Mar-2024

Summary

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Official Symbol
SORBS2provided by HGNC
Official Full Name
sorbin and SH3 domain containing 2provided by HGNC
Primary source
HGNC:HGNC:24098
See related
Ensembl:ENSG00000154556 MIM:616349; AllianceGenome:HGNC:24098
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARGBP2; PRO0618
Summary
Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Broad expression in heart (RPKM 46.6), adrenal (RPKM 26.3) and 19 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
4q35.1
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (185585523..185956372, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (188926307..189297353, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (186506677..186877526, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15856 Neighboring gene uncharacterized LOC105377590 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr4:186401399-186401900 Neighboring gene coiled-coil domain containing 110 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:186423455-186423954 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:186434842-186436041 Neighboring gene PDZ and LIM domain 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:186480278-186481124 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:186481125-186481969 Neighboring gene VISTA enhancer hs2502 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:186508176-186509375 Neighboring gene SORBS2 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:186559524-186560163 Neighboring gene Sharpr-MPRA regulatory region 2405 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:186633271-186633806 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:186650535-186650732 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:186658253-186658822 Neighboring gene Sharpr-MPRA regulatory region 123 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:186717334-186717850 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:186717851-186718366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:186742039-186742866 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:186760070-186761269 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:186784850-186784952 Neighboring gene uncharacterized LOC101928929 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC124900828 Neighboring gene uncharacterized LOC124900830 Neighboring gene uncharacterized LOC124900829

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Musk ketone induces apoptosis of gastric cancer cells via downregulation of sorbin and SH3 domain containing 2. An J, et al. Mol Med Rep, 2021 Jun. PMID 33880576, Free PMC Article
  2. Elevated myocardial SORBS2 and the underlying implications in left ventricular noncompaction cardiomyopathy. Li C, et al. EBioMedicine, 2020 Mar. PMID 32143182, Free PMC Article
  3. The RNA binding protein SORBS2 suppresses metastatic colonization of ovarian cancer by stabilizing tumor-suppressive immunomodulatory transcripts. Zhao L, et al. Genome Biol, 2018 Mar 16. PMID 29548303, Free PMC Article
  4. Sorbin and SH3 domain-containing protein 2 (SORBS2) is a component of the acto-myosin ring at the apical junctional complex in epithelial cells. Fredriksson-Lidman K, et al. PLoS One, 2017. PMID 28961272, Free PMC Article
  5. SORBS2 transcription is activated by telomere position effect-over long distance upon telomere shortening in muscle cells from patients with facioscapulohumeral dystrophy. Robin JD, et al. Genome Res, 2015 Dec. PMID 26359233, Free PMC Article

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SORBS2 is a genetic factor contributing to cardiac malformation of 4q deletion syndrome patients.
    Title: SORBS2 is a genetic factor contributing to cardiac malformation of 4q deletion syndrome patients.
  2. Musk ketone induces apoptosis of gastric cancer cells via downregulation of sorbin and SH3 domain containing 2.
    Title: Musk ketone induces apoptosis of gastric cancer cells via downregulation of sorbin and SH3 domain containing 2.
  3. LncRNA H19 Inhibits the Progression of Sepsis-Induced Myocardial Injury via Regulation of the miR-93-5p/SORBS2 Axis.
    Title: LncRNA H19 Inhibits the Progression of Sepsis-Induced Myocardial Injury via Regulation of the miR-93-5p/SORBS2 Axis.
  4. RNA-binding protein SORBS2 suppresses clear cell renal cell carcinoma metastasis by enhancing MTUS1 mRNA stability.
    Title: RNA-binding protein SORBS2 suppresses clear cell renal cell carcinoma metastasis by enhancing MTUS1 mRNA stability.
  5. Knockout of SORBS2 Protein Disrupts the Structural Integrity of Intercalated Disc and Manifests Features of Arrhythmogenic Cardiomyopathy.
    Title: Knockout of SORBS2 Protein Disrupts the Structural Integrity of Intercalated Disc and Manifests Features of Arrhythmogenic Cardiomyopathy.
  6. Elevated myocardial SORBS2 and the underlying implications in left ventricular noncompaction cardiomyopathy.
    Title: Elevated myocardial SORBS2 and the underlying implications in left ventricular noncompaction cardiomyopathy.
  7. The RNA-binding protein SORBS2 suppresses hepatocellular carcinoma tumourigenesis and metastasis by stabilizing RORA mRNA.
    Title: The RNA-binding protein SORBS2 suppresses hepatocellular carcinoma tumourigenesis and metastasis by stabilizing RORA mRNA.
  8. By enhancing the stability of gene transcripts, SORBS2 suppresses ovarian cancer invasiveness and affects monocyte to myeloid-derived suppressor cell and M2-like macrophage polarization, eliciting a tumor-suppressive immune microenvironment.
    Title: The RNA binding protein SORBS2 suppresses metastatic colonization of ovarian cancer by stabilizing tumor-suppressive immunomodulatory transcripts.
  9. results thus contribute to the knowledge of the regulatory mechanism of HSF1 in down-regulating ArgBP2, providing new insight into the HSF1&MORC2-PRC2-ArgBP2 signaling pathway and a better understanding of their functions in gastric cancer cells.
    Title: HSF1, in association with MORC2, downregulates ArgBP2 via the PRC2 family in gastric cancer cells.
  10. In spite of our finding that SORBS2 is clearly a component of the apical junction complex, it does not appear to be required for either normal tight- or adherens junction assembly, structure or function or for growth factor-mediated changes in tight junction dynamics
    Title: Sorbin and SH3 domain-containing protein 2 (SORBS2) is a component of the acto-myosin ring at the apical junctional complex in epithelial cells.
Submit: New GeneRIF Correction See all GeneRIFs (29)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr upregulates SORBS2 in HeLa cells within 12 hours of exposure PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ93447, KIAA0777

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables cytoskeletal anchor activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
 PubMed 
enables structural constituent of muscle TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in cell growth involved in cardiac muscle cell development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Z disc NAS
Non-traceable Author Statement
more info
 PubMed 
located_in actin cytoskeleton TAS
Traceable Author Statement
more info
 PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sorbin and SH3 domain-containing protein 2
Names
Arg binding protein 2
Arg/Abl-interacting protein 2
arg-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029709.1 RefSeqGene

    Range
    149523..376194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001145670.2 → NP_001139142.1  sorbin and SH3 domain-containing protein 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) originates from an alternate promoter and has a different 5'UTR and first coding exon compared to variant 1. The resulting protein isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC093797, AC104805, AC108472
    Consensus CDS
    CCDS47173.1
    UniProtKB/TrEMBL
    H7BXR3
    Related
    ENSP00000397262.2, ENST00000449407.6
    Conserved Domains (3) summary
    cd11923
    Location:485 → 541
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    pfam02208
    Location:156 → 197
    Sorb; Sorbin homologous domain
    cl17036
    Location:584 → 644
    SH3; Src Homology 3 domain superfamily

  2. NM_001145671.3 → NP_001139143.1  sorbin and SH3 domain-containing protein 2 isoform 4

    See identical proteins and their annotated locations for NP_001139143.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) originates from an alternate promoter and has a different 5'UTR and first coding exon and includes alternate in-frame exons compared to variant 1. The resulting protein isoform (4) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC093797, AC104805, AC108472
    Consensus CDS
    CCDS47174.1
    UniProtKB/TrEMBL
    H7BXR3
    Related
    ENSP00000322182.9, ENST00000319471.13
    Conserved Domains (3) summary
    smart00459
    Location:153 → 203
    Sorb; Sorbin homologous domain
    cd11923
    Location:572 → 628
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cl17036
    Location:671 → 731
    SH3; Src Homology 3 domain superfamily

  3. NM_001145672.2 → NP_001139144.1  sorbin and SH3 domain-containing protein 2 isoform 5

    See identical proteins and their annotated locations for NP_001139144.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) originates from an alternate promoter and has a different 5'UTR and first coding exon and includes alternate in-frame exons compared to variant 1. The resulting protein isoform (5) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC093797, AC104805, AC108472
    Consensus CDS
    CCDS54825.1
    UniProtKB/TrEMBL
    H7BXR3
    Related
    ENSP00000401818.2, ENST00000451974.6
    Conserved Domains (4) summary
    cd11923
    Location:502 → 558
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    PHA03132
    Location:219 → 411
    PHA03132; thymidine kinase; Provisional
    pfam02208
    Location:139 → 183
    Sorb; Sorbin homologous domain
    cl17036
    Location:601 → 661
    SH3; Src Homology 3 domain superfamily

  4. NM_001145673.3 → NP_001139145.1  sorbin and SH3 domain-containing protein 2 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) originates from an alternate promoter and has a different 5'UTR and first coding exon and includes alternate in-frame exons compared to variant 1. The resulting protein isoform (6) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC093797, AC104805, AC108472
    Consensus CDS
    CCDS47175.1
    UniProtKB/TrEMBL
    A0A9L9PXP6
    Related
    ENSP00000396008.2, ENST00000437304.6
    Conserved Domains (3) summary
    cd11923
    Location:665 → 721
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    pfam02208
    Location:249 → 293
    Sorb; Sorbin homologous domain
    cl17036
    Location:764 → 824
    SH3; Src Homology 3 domain superfamily

  5. NM_001145674.3 → NP_001139146.1  sorbin and SH3 domain-containing protein 2 isoform 7

    See identical proteins and their annotated locations for NP_001139146.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) originates from an alternate promoter and has a different 5'UTR and first coding exon compared to variant 1. The resulting protein isoform (7) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC093797
    Consensus CDS
    CCDS47176.1
    UniProtKB/Swiss-Prot
    O94875
    Related
    ENSP00000511887.1, ENST00000487836.6
    Conserved Domains (4) summary
    cd11917
    Location:944 → 1004
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:845 → 901
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cl02617
    Location:8 → 29
    Sorb; Sorbin homologous domain
    cl17036
    Location:770 → 824
    SH3; Src Homology 3 domain superfamily

  6. NM_001145675.3 → NP_001139147.1  sorbin and SH3 domain-containing protein 2 isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) originates from an alternate promoter and has a different 5' UTR and first coding exon compared to variant 1. The resulting protein isoform (8) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC093797
    Consensus CDS
    CCDS93677.1
    UniProtKB/TrEMBL
    A0A8Q3WKF2, B7Z997
    Related
    ENSP00000511889.1, ENST00000490562.6
    Conserved Domains (3) summary
    cd11923
    Location:333 → 389
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cl02617
    Location:8 → 33
    Sorb; Sorbin homologous domain
    cl17036
    Location:432 → 492
    SH3; Src Homology 3 domain superfamily

  7. NM_001270771.3 → NP_001257700.1  sorbin and SH3 domain-containing protein 2 isoform 9

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) originates from an alternate promoter, has a different 5' UTR, and several in-frame differences in the coding region compared to variant 1, which results in a longer isoform (7) compared to isoform 1.
    Source sequence(s)
    AC093797, AC096659, AC104805, AC108472
    Consensus CDS
    CCDS59482.1
    UniProtKB/Swiss-Prot
    O94875
    Related
    ENSP00000347852.5, ENST00000355634.9
    Conserved Domains (4) summary
    cd11917
    Location:1140 → 1200
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:966 → 1020
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1041 → 1097
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    pfam02208
    Location:170 → 214
    Sorb; Sorbin homologous domain

  8. NM_001394245.1 → NP_001381174.1  sorbin and SH3 domain-containing protein 2 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC093797, AC104805, AC108472
    Conserved Domains (4) summary
    smart00459
    Location:153 → 203
    Sorb; Sorbin homologous domain
    cd11917
    Location:1226 → 1286
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:1052 → 1106
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1127 → 1183
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  9. NM_001394246.1 → NP_001381175.1  sorbin and SH3 domain-containing protein 2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC093797, AC104805, AC108472
    Conserved Domains (4) summary
    smart00459
    Location:153 → 203
    Sorb; Sorbin homologous domain
    cd11917
    Location:1207 → 1267
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:1033 → 1087
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1108 → 1164
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  10. NM_001394247.1 → NP_001381176.1  sorbin and SH3 domain-containing protein 2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC093797, AC104805, AC108472
    Conserved Domains (4) summary
    smart00459
    Location:153 → 203
    Sorb; Sorbin homologous domain
    cd11917
    Location:1207 → 1267
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:1033 → 1087
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1108 → 1164
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  11. NM_001394248.1 → NP_001381177.1  sorbin and SH3 domain-containing protein 2 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC093797, AC096659, AC104805, AC108472
    Conserved Domains (4) summary
    smart00459
    Location:130 → 180
    Sorb; Sorbin homologous domain
    cd11917
    Location:1184 → 1244
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:1010 → 1064
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1085 → 1141
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  12. NM_001394249.1 → NP_001381178.1  sorbin and SH3 domain-containing protein 2 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC093797, AC104805, AC108472
    Conserved Domains (4) summary
    smart00459
    Location:130 → 180
    Sorb; Sorbin homologous domain
    cd11917
    Location:1184 → 1244
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:1010 → 1064
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1085 → 1141
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  13. NM_001394250.1 → NP_001381179.1  sorbin and SH3 domain-containing protein 2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC093797, AC104805, AC108472
    Conserved Domains (4) summary
    smart00459
    Location:153 → 203
    Sorb; Sorbin homologous domain
    cd11917
    Location:1179 → 1239
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:1005 → 1059
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1080 → 1136
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  14. NM_001394251.1 → NP_001381180.1  sorbin and SH3 domain-containing protein 2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC093797, AC104805, AC108472
    Consensus CDS
    CCDS59482.1
    Conserved Domains (4) summary
    cd11917
    Location:1140 → 1200
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:966 → 1020
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1041 → 1097
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    pfam02208
    Location:170 → 214
    Sorb; Sorbin homologous domain

  15. NM_001394252.1 → NP_001381181.1  sorbin and SH3 domain-containing protein 2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC093797, AC104805, AC108472
    Consensus CDS
    CCDS59482.1
    Conserved Domains (4) summary
    cd11917
    Location:1140 → 1200
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:966 → 1020
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1041 → 1097
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    pfam02208
    Location:170 → 214
    Sorb; Sorbin homologous domain

  16. NM_001394253.1 → NP_001381182.1  sorbin and SH3 domain-containing protein 2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC093797, AC104805, AC108472
    Consensus CDS
    CCDS59482.1
    Conserved Domains (4) summary
    cd11917
    Location:1140 → 1200
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:966 → 1020
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1041 → 1097
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    pfam02208
    Location:170 → 214
    Sorb; Sorbin homologous domain

  17. NM_001394254.1 → NP_001381183.1  sorbin and SH3 domain-containing protein 2 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC093797, AC104805, AC108472
    Consensus CDS
    CCDS93678.1
    UniProtKB/TrEMBL
    A0A8Q3WKH1
    Related
    ENSP00000511891.1, ENST00000695410.1
    Conserved Domains (4) summary
    smart00459
    Location:67 → 117
    Sorb; Sorbin homologous domain
    cd11917
    Location:1140 → 1200
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:966 → 1020
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1041 → 1097
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  18. NM_001394255.1 → NP_001381184.1  sorbin and SH3 domain-containing protein 2 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC093797, AC096659, AC104805, AC108472
    Conserved Domains (4) summary
    smart00459
    Location:153 → 203
    Sorb; Sorbin homologous domain
    cd11917
    Location:1126 → 1186
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:952 → 1006
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1027 → 1083
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  19. NM_001394256.1 → NP_001381185.1  sorbin and SH3 domain-containing protein 2 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC093797, AC104805, AC108472
    Conserved Domains (4) summary
    smart00459
    Location:153 → 203
    Sorb; Sorbin homologous domain
    cd11917
    Location:1126 → 1186
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:952 → 1006
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1027 → 1083
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  20. NM_001394257.1 → NP_001381186.1  sorbin and SH3 domain-containing protein 2 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC093797, AC096659, AC104805, AC108472
    Conserved Domains (4) summary
    smart00459
    Location:153 → 203
    Sorb; Sorbin homologous domain
    cd11917
    Location:1126 → 1186
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:952 → 1006
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1027 → 1083
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  21. NM_001394258.1 → NP_001381187.1  sorbin and SH3 domain-containing protein 2 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC093797, AC104805, AC108472
    Conserved Domains (4) summary
    smart00459
    Location:67 → 117
    Sorb; Sorbin homologous domain
    cd11917
    Location:1121 → 1181
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:947 → 1001
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1022 → 1078
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  22. NM_001394259.1 → NP_001381188.1  sorbin and SH3 domain-containing protein 2 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC093797, AC104805, AC108472
    Conserved Domains (4) summary
    smart00459
    Location:153 → 198
    Sorb; Sorbin homologous domain
    cd11917
    Location:1111 → 1171
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:937 → 991
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1012 → 1068
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  23. NM_001394260.1 → NP_001381189.1  sorbin and SH3 domain-containing protein 2 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC093797, AC104805, AC108472
    Conserved Domains (4) summary
    smart00459
    Location:153 → 198
    Sorb; Sorbin homologous domain
    cd11917
    Location:1111 → 1171
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:937 → 991
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1012 → 1068
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  24. NM_001394261.1 → NP_001381190.1  sorbin and SH3 domain-containing protein 2 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC093797, AC104805, AC108472
    Conserved Domains (4) summary
    smart00459
    Location:136 → 186
    Sorb; Sorbin homologous domain
    cd11917
    Location:1109 → 1169
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:935 → 989
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1010 → 1066
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  25. NM_001394262.1 → NP_001381191.1  sorbin and SH3 domain-containing protein 2 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC093797, AC096659, AC104805, AC108472
    Conserved Domains (4) summary
    smart00459
    Location:130 → 180
    Sorb; Sorbin homologous domain
    cd11917
    Location:1103 → 1163
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:929 → 983
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1004 → 1060
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  26. NM_001394263.1 → NP_001381192.1  sorbin and SH3 domain-containing protein 2 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC093797, AC104805, AC108472
    Conserved Domains (4) summary
    smart00459
    Location:130 → 180
    Sorb; Sorbin homologous domain
    cd11917
    Location:1103 → 1163
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:929 → 983
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1004 → 1060
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  27. NM_001394264.1 → NP_001381193.1  sorbin and SH3 domain-containing protein 2 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC093797, AC096659, AC104805, AC108472
    Conserved Domains (4) summary
    smart00459
    Location:67 → 112
    Sorb; Sorbin homologous domain
    cd11917
    Location:1078 → 1138
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:904 → 958
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:979 → 1035
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  28. NM_001394265.1 → NP_001381194.1  sorbin and SH3 domain-containing protein 2 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC093797, AC104805, AC108472
    Conserved Domains (4) summary
    smart00459
    Location:113 → 158
    Sorb; Sorbin homologous domain
    cd11917
    Location:1071 → 1131
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:897 → 951
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:972 → 1028
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  29. NM_001394266.1 → NP_001381195.1  sorbin and SH3 domain-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC093797, AC096659, AC104805, AC108472
    Consensus CDS
    CCDS3845.1
    UniProtKB/Swiss-Prot
    A6NEK9, B3KPQ7, B7Z1G5, B7Z3X6, C9JKV9, D3DP62, D3DP63, E9PAS5, E9PAW4, G3XAI0, H7BXR4, J3KNZ5, O60592, O60593, O94875, Q96EX0
    Conserved Domains (4) summary
    smart00459
    Location:67 → 117
    Sorb; Sorbin homologous domain
    cd11917
    Location:1040 → 1100
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:866 → 920
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:941 → 997
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  30. NM_001394267.1 → NP_001381196.1  sorbin and SH3 domain-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC093797, AC096659, AC104805, AC108472
    Consensus CDS
    CCDS3845.1
    UniProtKB/Swiss-Prot
    A6NEK9, B3KPQ7, B7Z1G5, B7Z3X6, C9JKV9, D3DP62, D3DP63, E9PAS5, E9PAW4, G3XAI0, H7BXR4, J3KNZ5, O60592, O60593, O94875, Q96EX0
    Conserved Domains (4) summary
    smart00459
    Location:67 → 117
    Sorb; Sorbin homologous domain
    cd11917
    Location:1040 → 1100
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:866 → 920
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:941 → 997
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  31. NM_001394268.1 → NP_001381197.1  sorbin and SH3 domain-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC093797, AC096659, AC104805, AC108472
    Consensus CDS
    CCDS3845.1
    UniProtKB/Swiss-Prot
    A6NEK9, B3KPQ7, B7Z1G5, B7Z3X6, C9JKV9, D3DP62, D3DP63, E9PAS5, E9PAW4, G3XAI0, H7BXR4, J3KNZ5, O60592, O60593, O94875, Q96EX0
    Conserved Domains (4) summary
    smart00459
    Location:67 → 117
    Sorb; Sorbin homologous domain
    cd11917
    Location:1040 → 1100
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:866 → 920
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:941 → 997
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  32. NM_001394270.1 → NP_001381199.1  sorbin and SH3 domain-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC093797, AC104805, AC108472
    Consensus CDS
    CCDS3845.1
    UniProtKB/Swiss-Prot
    A6NEK9, B3KPQ7, B7Z1G5, B7Z3X6, C9JKV9, D3DP62, D3DP63, E9PAS5, E9PAW4, G3XAI0, H7BXR4, J3KNZ5, O60592, O60593, O94875, Q96EX0
    Conserved Domains (4) summary
    smart00459
    Location:67 → 117
    Sorb; Sorbin homologous domain
    cd11917
    Location:1040 → 1100
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:866 → 920
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:941 → 997
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  33. NM_001394271.1 → NP_001381200.1  sorbin and SH3 domain-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC093797, AC104805, AC108472
    Consensus CDS
    CCDS3845.1
    UniProtKB/Swiss-Prot
    A6NEK9, B3KPQ7, B7Z1G5, B7Z3X6, C9JKV9, D3DP62, D3DP63, E9PAS5, E9PAW4, G3XAI0, H7BXR4, J3KNZ5, O60592, O60593, O94875, Q96EX0
    Conserved Domains (4) summary
    smart00459
    Location:67 → 117
    Sorb; Sorbin homologous domain
    cd11917
    Location:1040 → 1100
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:866 → 920
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:941 → 997
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  34. NM_001394272.1 → NP_001381201.1  sorbin and SH3 domain-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC093797, AC104805, AC108472
    Consensus CDS
    CCDS3845.1
    UniProtKB/Swiss-Prot
    A6NEK9, B3KPQ7, B7Z1G5, B7Z3X6, C9JKV9, D3DP62, D3DP63, E9PAS5, E9PAW4, G3XAI0, H7BXR4, J3KNZ5, O60592, O60593, O94875, Q96EX0
    Conserved Domains (4) summary
    smart00459
    Location:67 → 117
    Sorb; Sorbin homologous domain
    cd11917
    Location:1040 → 1100
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:866 → 920
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:941 → 997
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  35. NM_001394273.1 → NP_001381202.1  sorbin and SH3 domain-containing protein 2 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC093797
    Conserved Domains (4) summary
    cd11917
    Location:1031 → 1091
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:857 → 911
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:932 → 988
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cl02617
    Location:4 → 36
    Sorb; Sorbin homologous domain

  36. NM_001394274.1 → NP_001381203.1  sorbin and SH3 domain-containing protein 2 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC093797, AC104805, AC108472
    Conserved Domains (4) summary
    smart00459
    Location:67 → 112
    Sorb; Sorbin homologous domain
    cd11917
    Location:1025 → 1085
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:851 → 905
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:926 → 982
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  37. NM_001394275.1 → NP_001381204.1  sorbin and SH3 domain-containing protein 2 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC093797, AC104805, AC108472
    Conserved Domains (4) summary
    smart00459
    Location:67 → 112
    Sorb; Sorbin homologous domain
    cd11917
    Location:1025 → 1085
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:851 → 905
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:926 → 982
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  38. NM_001394276.1 → NP_001381205.1  sorbin and SH3 domain-containing protein 2 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC093797, AC104805, AC108472
    Conserved Domains (4) summary
    smart00459
    Location:485 → 535
    Sorb; Sorbin homologous domain
    cd11917
    Location:1003 → 1063
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:829 → 883
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:904 → 960
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  39. NM_001394277.1 → NP_001381206.1  sorbin and SH3 domain-containing protein 2 isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC093797
    Conserved Domains (4) summary
    cd11917
    Location:959 → 1019
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:785 → 839
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:860 → 916
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cl02617
    Location:4 → 36
    Sorb; Sorbin homologous domain

  40. NM_001395207.1 → NP_001382136.1  sorbin and SH3 domain-containing protein 2 isoform 26

    Status: REVIEWED

    Description
    Transcript Variant: This variant (42) represents the longest transcript and encodes the longest isoform (26).
    Source sequence(s)
    AC093797, AC104805, AC108472
    Consensus CDS
    CCDS93679.1
    UniProtKB/TrEMBL
    A0A8Q3WKK4
    Related
    ENSP00000511888.1, ENST00000695409.1
    Conserved Domains (4) summary
    smart00459
    Location:167 → 217
    Sorb; Sorbin homologous domain
    cd11917
    Location:1240 → 1300
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:1066 → 1120
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1141 → 1197
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  41. NM_003603.7 → NP_003594.3  sorbin and SH3 domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_003594.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs at the 5' end, and contains a small in-frame insertion and a large in-frame deletion compared to transcript variant 2. It encodes a shorter isoform (1) with a different amino-terminal, but the same carboxy-terminal sequence containing three SH3 domains, as isoform 2.
    Source sequence(s)
    AC093797, AC104805, AC108472
    Consensus CDS
    CCDS43289.2
    UniProtKB/TrEMBL
    H7BXR3
    Related
    ENSP00000377162.3, ENST00000393528.7
    Conserved Domains (3) summary
    smart00459
    Location:113 → 163
    Sorb; Sorbin homologous domain
    cd11923
    Location:507 → 563
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cl17036
    Location:606 → 666
    SH3; Src Homology 3 domain superfamily

  42. NM_021069.6 → NP_066547.1  sorbin and SH3 domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_066547.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs at the 5' end, and contains a large in-frame insertion and a small in-frame deletion compared to transcript variant 1. It encodes a longer isoform (2) with a different amino-terminal, but the same carboxy-terminal sequence containing three SH3 domains, as isoform 1.
    Source sequence(s)
    AC093797, AC096659, AC104805, AC108472
    Consensus CDS
    CCDS3845.1
    UniProtKB/Swiss-Prot
    A6NEK9, B3KPQ7, B7Z1G5, B7Z3X6, C9JKV9, D3DP62, D3DP63, E9PAS5, E9PAW4, G3XAI0, H7BXR4, J3KNZ5, O60592, O60593, O94875, Q96EX0
    Related
    ENSP00000284776.7, ENST00000284776.11
    Conserved Domains (4) summary
    smart00459
    Location:67 → 117
    Sorb; Sorbin homologous domain
    cd11917
    Location:1040 → 1100
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:866 → 920
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:941 → 997
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    185585523..185956372 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    188926307..189297353 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O94875.3 GenPept UniProtKB/Swiss-Prot:O94875

Gene LinkOut

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