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ACCS 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) [ Homo sapiens (human) ]

Gene ID: 84680, updated on 3-Apr-2024

Summary

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Official Symbol
ACCSprovided by HGNC
Official Full Name
1-aminocyclopropane-1-carboxylate synthase homolog (inactive)provided by HGNC
Primary source
HGNC:HGNC:23989
See related
Ensembl:ENSG00000110455 MIM:608405; AllianceGenome:HGNC:23989
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACS; PHACS
Summary
Enables identical protein binding activity. Predicted to be involved in biosynthetic process. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 11.2), gall bladder (RPKM 7.3) and 25 other tissues See more
Orthologs
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Genomic context

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See ACCS in Genome Data Viewer
Location:
11p11.2
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (44066270..44084237)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (44221451..44239584)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (44087820..44105787)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902663 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:43949635-43950136 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:43955407-43955585 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3270 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3271 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:43964814-43965643 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:43965644-43966472 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:43968482-43968982 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:43977126-43977352 Neighboring gene 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) like Neighboring gene chromosome 11 open reading frame 96 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44003904-44004404 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44004405-44004905 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:44026425-44027286 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:44028815-44029314 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:44035825-44036324 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4649 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4648 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3272 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4650 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4651 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4652 Neighboring gene exostosin glycosyltransferase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44199715-44200215 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:44218806-44220005 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44283363-44283862 Neighboring gene VISTA enhancer hs2090 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:44299108-44299425 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44307156-44308129 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44308130-44309102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44331667-44332595 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:44325021-44325566 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:44324475-44325020 Neighboring gene ALX homeobox 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The human cDNA for a homologue of the plant enzyme 1-aminocyclopropane-1-carboxylate synthase encodes a protein lacking that activity. Koch KA, et al. Gene, 2001 Jul 11. PMID 11470512
  2. A Large-scale genetic association study of esophageal adenocarcinoma risk. Liu CY, et al. Carcinogenesis, 2010 Jul. PMID 20453000, Free PMC Article
  3. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. Yang X, et al. Cell, 2016 Feb 11. PMID 26871637, Free PMC Article
  4. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512
  5. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. Fragoza R, et al. Nat Commun, 2019 Sep 12. PMID 31515488, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: A Large-scale genetic association study of esophageal adenocarcinoma risk.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables 1-aminocyclopropane-1-carboxylate synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables pyridoxal phosphate binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables transaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in amino acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
1-aminocyclopropane-1-carboxylate synthase-like protein 1
Names
ACC synthase-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127219.2 → NP_001120691.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1

    See identical proteins and their annotated locations for NP_001120691.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC134775, BC020197, DA196370
    Consensus CDS
    CCDS7907.1
    UniProtKB/Swiss-Prot
    B4E219, Q8WUL4, Q96LX5, Q96QU6
    UniProtKB/TrEMBL
    A0A0S2Z5S5, A0A0S2Z622
    Conserved Domains (2) summary
    cd00609
    Location:99 → 476
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
    PLN02450
    Location:53 → 499
    PLN02450; 1-aminocyclopropane-1-carboxylate synthase

  2. NM_032592.4 → NP_115981.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1

    See identical proteins and their annotated locations for NP_115981.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC134775, BC020197, DA406116, DC390076
    Consensus CDS
    CCDS7907.1
    UniProtKB/Swiss-Prot
    B4E219, Q8WUL4, Q96LX5, Q96QU6
    UniProtKB/TrEMBL
    A0A0S2Z5S5, A0A0S2Z622
    Related
    ENSP00000263776.8, ENST00000263776.9
    Conserved Domains (2) summary
    cd00609
    Location:99 → 476
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
    PLN02450
    Location:53 → 499
    PLN02450; 1-aminocyclopropane-1-carboxylate synthase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    44066270..44084237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005253170.4 → XP_005253227.2  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X1

    Conserved Domains (1) summary
    PLN02450
    Location:154 → 600
    PLN02450; 1-aminocyclopropane-1-carboxylate synthase

  2. XM_011520406.3 → XP_011518708.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X2

    Conserved Domains (1) summary
    cd00609
    Location:200 → 520
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...

  3. XM_024448718.2 → XP_024304486.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A0S2Z5Z8
    Conserved Domains (1) summary
    PLN02450
    Location:53 → 417
    PLN02450; 1-aminocyclopropane-1-carboxylate synthase

  4. XM_024448719.2 → XP_024304487.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A0S2Z5Z8
    Conserved Domains (1) summary
    PLN02450
    Location:53 → 417
    PLN02450; 1-aminocyclopropane-1-carboxylate synthase

  5. XM_047427717.1 → XP_047283673.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X6

  6. XM_047427719.1 → XP_047283675.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X8

  7. XM_017018421.2 → XP_016873910.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X8

  8. XM_011520407.1 → XP_011518709.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X4

    Conserved Domains (1) summary
    cd00609
    Location:6 → 355
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...

  9. XM_005253172.2 → XP_005253229.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X5

    Conserved Domains (1) summary
    cd00609
    Location:9 → 346
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...

  10. XM_047427718.1 → XP_047283674.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X7

  11. XM_006718348.3 → XP_006718411.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X7

    See identical proteins and their annotated locations for XP_006718411.1

    Conserved Domains (1) summary
    cl27741
    Location:45 → 317
    Aminotran_1_2; Aminotransferase class I and II

RNA

  1. XR_007062513.1 RNA Sequence

  2. XR_007062514.1 RNA Sequence

  3. XR_001748005.2 RNA Sequence

  4. XR_001748008.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    44221451..44239584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370206.1 → XP_054226181.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X1

  2. XM_054370207.1 → XP_054226182.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X2

  3. XM_054370212.1 → XP_054226187.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X6

  4. XM_054370215.1 → XP_054226190.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X8

  5. XM_054370216.1 → XP_054226191.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X8

  6. XM_054370208.1 → XP_054226183.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X3

  7. XM_054370209.1 → XP_054226184.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X3

  8. XM_054370210.1 → XP_054226185.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X4

  9. XM_054370211.1 → XP_054226186.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X5

  10. XM_054370213.1 → XP_054226188.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X7

  11. XM_054370214.1 → XP_054226189.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X7

RNA

  1. XR_008488470.1 RNA Sequence

  2. XR_008488471.1 RNA Sequence

  3. XR_008488472.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96QU6.1 GenPept UniProtKB/Swiss-Prot:Q96QU6

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