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TRIM55 tripartite motif containing 55 [ Homo sapiens (human) ]

Gene ID: 84675, updated on 5-Mar-2024

Summary

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Official Symbol
TRIM55provided by HGNC
Official Full Name
tripartite motif containing 55provided by HGNC
Primary source
HGNC:HGNC:14215
See related
Ensembl:ENSG00000147573 MIM:606469; AllianceGenome:HGNC:14215
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF29; muRF2; MURF-2
Summary
The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein associates transiently with microtubules, myosin, and titin during muscle sarcomere assembly. It may act as a transient adaptor and plays a regulatory role in the assembly of sarcomeres. Four alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Biased expression in heart (RPKM 14.3), liver (RPKM 6.5) and 2 other tissues See more
Orthologs
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Genomic context

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Location:
8q13.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (66113351..66175485)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (66538238..66601172)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (67039364..67087720)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986950 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27466 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27467 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27469 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:66862529-66863728 Neighboring gene uncharacterized LOC105375883 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27470 Neighboring gene Sharpr-MPRA regulatory region 3041 Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 beta Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19250 Neighboring gene Sharpr-MPRA regulatory region 492 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27472 Neighboring gene H3K27ac hESC enhancers GRCh37_chr8:67025273-67025924 and GRCh37_chr8:67025925-67026577 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27471 Neighboring gene tRNA-Tyr (anticodon GTA) 5-1 Neighboring gene tRNA-Tyr (anticodon GTA) 5-2 Neighboring gene tRNA-Ala (anticodon AGC) 8-2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:67035753-67036952 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:67038910-67039182 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27476 Neighboring gene uncharacterized LOC112268029 Neighboring gene uncharacterized LOC124901954 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr8:67098699-67099309 Neighboring gene corticotropin releasing hormone

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TRIM55 inhibits colorectal cancer development via enhancing protein degradation of c-Myc. Lin M, et al. Cancer Med, 2023 Jun. PMID 37212463, Free PMC Article
  2. Overexpression of Tripartite Motif Conaining 55 (TRIM55) Inhibits Migration and Invasion of Hepatocellular Carcinoma (HCC) Cells via Epithelial-Mesenchymal Transition and Matrix Metalloproteinase-2 (MMP2). Li X, et al. Med Sci Monit, 2019 Jan 27. PMID 30685767, Free PMC Article
  3. Genome-wide study of gene variants associated with differential cardiovascular event reduction by pravastatin therapy. Shiffman D, et al. PLoS One, 2012. PMID 22666496, Free PMC Article
  4. Genetic and functional implications of an exonic TRIM55 variant in heart failure. Heliste J, et al. J Mol Cell Cardiol, 2020 Jan. PMID 31866377
  5. Perturbation of the titin/MURF1 signaling complex is associated with hypertrophic cardiomyopathy in a fish model and in human patients. Higashikuse Y, et al. Dis Model Mech, 2019 Nov 15. PMID 31628103, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SUMO-3 promotes the ubiquitin-dependent turnover of TRIM55.
    Title: SUMO-3 promotes the ubiquitin-dependent turnover of TRIM55.
  2. TRIM55 inhibits colorectal cancer development via enhancing protein degradation of c-Myc.
    Title: TRIM55 inhibits colorectal cancer development via enhancing protein degradation of c-Myc.
  3. Genetic and functional implications of an exonic TRIM55 variant in heart failure.
    Title: Genetic and functional implications of an exonic TRIM55 variant in heart failure.
  4. Overexpression of TRIM55 was associated with lower cell migration and invasion ability, and it led to high expression of E-cadherin and low expression of Vimentin and MMP2.
    Title: Overexpression of Tripartite Motif Conaining 55 (TRIM55) Inhibits Migration and Invasion of Hepatocellular Carcinoma (HCC) Cells via Epithelial-Mesenchymal Transition and Matrix Metalloproteinase-2 (MMP2).
  5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide study of gene variants associated with differential cardiovascular event reduction by pravastatin therapy.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of tripartite motif containing 55 (TRIM55) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed
Knockdown of tripartite motif containing 55 (TRIM55) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • AC084082.3

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in diapedesis IEA
Inferred from Electronic Annotation
more info
  
involved_in leukocyte migration involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in macrophage migration IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of non-canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IC
Inferred by Curator
more info
 PubMed 
located_in microtubule NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tripartite motif-containing protein 55
Names
muscle specific ring finger 2
muscle-specific RING finger protein 2
ring finger protein 29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033058.3 → NP_149047.2  tripartite motif-containing protein 55 isoform 2

    See identical proteins and their annotated locations for NP_149047.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an additional exon within the coding region compared to variant 1, which causes a frameshift. The resulting isoform (2) has a distinct and shorter C-terminus, as compared to isoform 1.
    Source sequence(s)
    AJ431704, AK091310
    Consensus CDS
    CCDS6187.1
    UniProtKB/Swiss-Prot
    Q9BYV6
    Related
    ENSP00000276573.7, ENST00000276573.11
    Conserved Domains (3) summary
    cd00162
    Location:26 → 85
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00643
    Location:119 → 161
    zf-B_box; B-box zinc finger
    cl23765
    Location:168 → 294
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  2. NM_184085.2 → NP_908973.1  tripartite motif-containing protein 55 isoform 1

    See identical proteins and their annotated locations for NP_908973.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AJ291712, AK091310
    Consensus CDS
    CCDS6184.1
    UniProtKB/Swiss-Prot
    B3KRC0, B3KRJ3, Q53XX3, Q8IUD9, Q8IUE4, Q96DV2, Q96DV3, Q9BYV5, Q9BYV6
    Related
    ENSP00000323913.4, ENST00000315962.9
    Conserved Domains (3) summary
    cd00162
    Location:26 → 85
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00643
    Location:119 → 161
    zf-B_box; B-box zinc finger
    cl23765
    Location:168 → 294
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  3. NM_184086.2 → NP_908974.1  tripartite motif-containing protein 55 isoform 3

    See identical proteins and their annotated locations for NP_908974.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon within the coding region compared to variant 1. The resulting isoform (3) lacks an internal region, as compared to isoform 1.
    Source sequence(s)
    AK091310
    Consensus CDS
    CCDS6185.1
    UniProtKB/Swiss-Prot
    Q9BYV6
    Related
    ENSP00000297348.8, ENST00000353317.9
    Conserved Domains (3) summary
    pfam00643
    Location:119 → 161
    zf-B_box; B-box zinc finger
    cd16760
    Location:21 → 84
    RING-HC_MuRF2; RING finger, HC subclass, found in muscle-specific RING finger protein 2 (MuRF-2) and similar proteins
    cl25407
    Location:168 → 294
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  4. NM_184087.2 → NP_908975.1  tripartite motif-containing protein 55 isoform 4

    See identical proteins and their annotated locations for NP_908975.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks four exons within the coding region compared to variant 1. The translation frame remains the same. The resulting isoform (4) lacks an internal region, as compared to isoform 1. This isoform (4) was detected specifically in cardiac muscle.
    Source sequence(s)
    AJ277493, AK091310
    Consensus CDS
    CCDS6186.1
    UniProtKB/Swiss-Prot
    Q9BYV6
    Related
    ENSP00000332302.4, ENST00000350034.4
    Conserved Domains (2) summary
    cd16760
    Location:21 → 84
    RING-HC_MuRF2; RING finger, HC subclass, found in muscle-specific RING finger protein 2 (MuRF-2) and similar proteins
    cl00034
    Location:122 → 166
    Bbox_SF; B-box-type zinc finger superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    66113351..66175485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517617.3 → XP_011515919.1  tripartite motif-containing protein 55 isoform X4

    Conserved Domains (2) summary
    pfam00643
    Location:1 → 39
    zf-B_box; B-box zinc finger
    cl23765
    Location:46 → 172
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  2. XM_017013908.2 → XP_016869397.1  tripartite motif-containing protein 55 isoform X2

  3. XM_005251316.5 → XP_005251373.1  tripartite motif-containing protein 55 isoform X1

    Conserved Domains (3) summary
    cd00162
    Location:26 → 85
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00643
    Location:119 → 161
    zf-B_box; B-box zinc finger
    cl23765
    Location:168 → 294
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  4. XM_024447308.1 → XP_024303076.1  tripartite motif-containing protein 55 isoform X3

    Conserved Domains (3) summary
    pfam00643
    Location:119 → 161
    zf-B_box; B-box zinc finger
    cd16760
    Location:21 → 84
    RING-HC_MuRF2; RING finger, HC subclass, found in muscle-specific RING finger protein 2 (MuRF-2) and similar proteins
    cl25407
    Location:168 → 294
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    66538238..66601172
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361361.1 → XP_054217336.1  tripartite motif-containing protein 55 isoform X5

    UniProtKB/Swiss-Prot
    B3KRC0, B3KRJ3, Q53XX3, Q8IUD9, Q8IUE4, Q96DV2, Q96DV3, Q9BYV5, Q9BYV6

  2. XM_054361363.1 → XP_054217338.1  tripartite motif-containing protein 55 isoform X5

    UniProtKB/Swiss-Prot
    B3KRC0, B3KRJ3, Q53XX3, Q8IUD9, Q8IUE4, Q96DV2, Q96DV3, Q9BYV5, Q9BYV6

  3. XM_054361369.1 → XP_054217344.1  tripartite motif-containing protein 55 isoform X4

  4. XM_054361365.1 → XP_054217340.1  tripartite motif-containing protein 55 isoform X6

  5. XM_054361364.1 → XP_054217339.1  tripartite motif-containing protein 55 isoform X1

  6. XM_054361360.1 → XP_054217335.1  tripartite motif-containing protein 55 isoform X5

    UniProtKB/Swiss-Prot
    B3KRC0, B3KRJ3, Q53XX3, Q8IUD9, Q8IUE4, Q96DV2, Q96DV3, Q9BYV5, Q9BYV6

  7. XM_054361362.1 → XP_054217337.1  tripartite motif-containing protein 55 isoform X5

    UniProtKB/Swiss-Prot
    B3KRC0, B3KRJ3, Q53XX3, Q8IUD9, Q8IUE4, Q96DV2, Q96DV3, Q9BYV5, Q9BYV6

  8. XM_054361368.1 → XP_054217343.1  tripartite motif-containing protein 55 isoform X3

  9. XM_054361367.1 → XP_054217342.1  tripartite motif-containing protein 55 isoform X7

  10. XM_054361366.1 → XP_054217341.1  tripartite motif-containing protein 55 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BYV6.2 GenPept UniProtKB/Swiss-Prot:Q9BYV6

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