RETNLB resistin like beta [Homo sapiens (human)] - Gene

Summary

Official Symbol: RETNLBprovided by HGNC
Official Full Name: resistin like betaprovided by HGNC
Primary source: HGNC:HGNC:20388
See related: Ensembl:ENSG00000163515 MIM:605645; AllianceGenome:HGNC:20388
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: XCP2; FIZZ1; FIZZ2; HXCP2; RELMb; RELMbeta; RELM-beta
Summary: Predicted to enable hormone activity. Involved in epithelial cell proliferation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in colon (RPKM 39.2), small intestine (RPKM 12.6) and 1 other tissue See more
Orthologs: mouse all
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Genomic context

Location:: 3q13.13

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (108755638..108757410, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (111476011..111477791, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (108474485..108476257, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Resistin-like beta reduction is associated to low survival rate and is downregulated by adjuvant therapy in colorectal cancer patients.
Title: Resistin-like beta reduction is associated to low survival rate and is downregulated by adjuvant therapy in colorectal cancer patients.
Investigating resistin like beta (RETNLB) as a tumor promoter for oral squamous cell carcinoma.
Title: Investigating resistin like beta (RETNLB) as a tumor promoter for oral squamous cell carcinoma.
Helicobacter pylori Infection Facilitates the Expression of Resistin-like Molecule Beta in Gastric Carcinoma and Precursor Lesions.
Title: Helicobacter pylori Infection Facilitates the Expression of Resistin-like Molecule Beta in Gastric Carcinoma and Precursor Lesions.
Plasma RELMbeta levels in necrotizing enterocolitis group were significantly higher than control group.
Title: Early diagnosis of necrotizing enterocolitis by plasma RELMβ and thrombocytopenia in preterm infants: A pilot study.
Investigated the function and mechanism of RELM-beta in TGF-beta1-induced endothelium-mesenchymal transition in endothelial cell lines. We found that TGF-beta1 stimulation significantly upregulated RELM-beta expression; RELM-beta knockdown could attenuate TGF-beta1-induced cell proliferation and migration of endothelial cell lines.
Title: TGF-β1-induced SMAD2/3/4 activation promotes RELM-β transcription to modulate the endothelium-mesenchymal transition in human endothelial cells.
RELMbeta-overexpression can facilitate invasion and migration of gastric carcinoma cells.
Title: Resistin-Like Molecule-β Promotes Invasion and Migration of Gastric Carcinoma Cells.
RELMbeta levels were increased in Abdominal aortic aneurysm patients in the serum and in the aortic tissue. Increased RELMbeta levels may be involved in the pathogenesis of AAA formation and progress.
Title: Association of resistin-like molecule β levels and abdominal aortic aneurysm.
The data demonstrated that RELM-a is a promising novel biomarker of angiogenesis in patients with gastric cancer.
Title: High expression of RELM-α correlates with poor prognosis and promotes angiogenesis in gastric cancer.
elevated RELM-beta expression in asthmatic airways contributes to airways remodelling at least partly by increasing fibroblast proliferation and differentiation with resulting deposition of extracellular matrix proteins.
Title: Resistin-like molecule-β (RELM-β) targets airways fibroblasts to effect remodelling in asthma: from mouse to man.
It is concluded that proper exercise training prevents up-regulation of FIZZ1/RELMalpha induced by cigarette smoking, which may be involved in the mechanism of proper exercise training modulating airway hyperresponsiveness.
Title: Exercise training attenuated chronic cigarette smoking-induced up-regulation of FIZZ1/RELMα in lung of rats.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:480717

NoName (e-PCR)
- UniSTS:485842

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in epithelial cell proliferation	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: resistin-like beta

Names: C/EBP-epsilon regulated myeloid-specific secreted cysteine-rich protein precursor 2; colon and small intestine-specific cysteine-rich protein; colon carcinoma-related gene protein; cysteine-rich secreted A12-alpha-like protein 1; cysteine-rich secreted protein A12-alpha-like 1; cysteine-rich secreted protein FIZZ2; found in inflammatory zone 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001412183.1 → NP_001399112.1 resistin-like beta isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses the same exon combination as variant 1 but represents the allele encoded by the T2T-CHM13v2.0 genome assembly. The encoded isoform (2) uses a downstream in-frame start codon and has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

CP068275
NM_032579.3 → NP_115968.1 resistin-like beta isoform 1 precursor

See identical proteins and their annotated locations for NP_115968.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) uses the same exon combination as variant 2 but represents the allele encoded by the GRCh38 reference genome. The encoded isoform (1) has a longer N-terminus than isoform 2.

Source sequence(s)

AC092185, AY358655

Consensus CDS

CCDS2953.1

UniProtKB/Swiss-Prot

Q14D27, Q9BQ08

UniProtKB/TrEMBL

Q2UXL7

Related

ENSP00000295755.6, ENST00000295755.7

Conserved Domains (1) summary

pfam06954
Location:23 → 110

Resistin; Resistin