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TPST1 tyrosylprotein sulfotransferase 1 [ Homo sapiens (human) ]

Gene ID: 8460, updated on 11-Apr-2024

Summary

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Official Symbol
TPST1provided by HGNC
Official Full Name
tyrosylprotein sulfotransferase 1provided by HGNC
Primary source
HGNC:HGNC:12020
See related
Ensembl:ENSG00000169902 MIM:603125; AllianceGenome:HGNC:12020
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TANGO13A
Summary
Enables protein homodimerization activity and protein-tyrosine sulfotransferase activity. Involved in peptidyl-tyrosine sulfation. Is integral component of Golgi membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in gall bladder (RPKM 13.2), urinary bladder (RPKM 9.5) and 22 other tissues See more
Orthologs
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Genomic context

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Location:
7q11.21
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (66198790..66360443)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (67420877..67582531)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (65670321..65825430)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18203 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26080 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:65551291-65551918 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:65565192-65565753 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:65578710-65578900 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26081 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:65580214-65580742 Neighboring gene argininosuccinate lyase Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:65612993-65614192 Neighboring gene CGRP receptor component Neighboring gene ReSE screen-validated silencer GRCh37_chr7:65642926-65643089 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18204 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18205 Neighboring gene MPRA-validated peak6545 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr7:65779787-65780442 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:65814565-65815064 Neighboring gene RNA, U6 small nuclear 313, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr7:65827447-65827611 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:65853152-65853652 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:65853653-65854153 Neighboring gene long intergenic non-protein coding RNA 174 Neighboring gene uncharacterized LOC124901822 Neighboring gene general transcription factor IIi pseudogene 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification and characterization of tyrosylprotein sulfotransferase from human saliva. Kasinathan C, et al. Int J Biol Sci, 2005. PMID 16244708, Free PMC Article
  2. Tyrosylprotein sulfotransferase 1 expression is negatively correlated with c‑Met and lymph node metastasis in human lung cancer. Jiang Z, et al. Mol Med Rep, 2015 Oct. PMID 26238632
  3. Genetic variation in microRNA-binding site and prognosis of patients with colorectal cancer. Kim JG, et al. J Cancer Res Clin Oncol, 2015 Jan. PMID 25079514
  4. Mass spectrometric kinetic analysis of human tyrosylprotein sulfotransferase-1 and -2. Danan LM, et al. J Am Soc Mass Spectrom, 2008 Oct. PMID 18672380, Free PMC Article
  5. Human TPST1 transmembrane domain triggers enzyme dimerisation and localisation to the Golgi compartment. Goettsch S, et al. J Mol Biol, 2006 Aug 18. PMID 16859706

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TPST1 was significantly negatively correlated with the expression of cMet in lung cancer and may be a negative prognostic biomarker of lung cancer.
    Title: Tyrosylprotein sulfotransferase 1 expression is negatively correlated with c‑Met and lymph node metastasis in human lung cancer.
  2. TPST1 rs3757417T>G polymorphisms are associated with colorectal cancer.
    Title: Genetic variation in microRNA-binding site and prognosis of patients with colorectal cancer.
  3. up-regulation of TPST-1 and tyrosine sulfation of CXCR4 by LMP1 might be a potential mechanism contributing to nasopharyngeal carcinoma metastasis
    Title: Tyrosylprotein sulfotransferase-1 and tyrosine sulfation of chemokine receptor 4 are induced by Epstein-Barr virus encoded latent membrane protein 1 and associated with the metastatic potential of human nasopharyngeal carcinoma.
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  5. Affinity purified salivary TPST showed a single band of 50-54 kDa and is the first report characterizing a tyrosylprotein sulfotransferase in secretory fluid from the parotid gland
    Title: Identification and characterization of tyrosylprotein sulfotransferase from human saliva.
  6. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.
  7. The kinetic parameters of tyrosylprotein sulfotransferase-1 and -2, catalyzing tyrosine sulfation of CCR8 peptides, were determined using liquid chromatography electrospray ionisation mass spectrometry.
    Title: Mass spectrometric kinetic analysis of human tyrosylprotein sulfotransferase-1 and -2.
  8. results exclude TPST1 as the causative gene for Shwachman-Diamond syndrome
    Title: Fine mapping of the locus for Shwachman-Diamond syndrome at 7q11, identification of shared disease haplotypes, and exclusion of TPST1 as a candidate gene.
  9. Human tyrosylprotein sulfotransferase may be functional as homodimer/oligomer in the trans-Golgi compartment.
    Title: Human TPST1 transmembrane domain triggers enzyme dimerisation and localisation to the Golgi compartment.
  10. Tyrosine sulfation of CCR5 N-terminal peptide follows a discrete pattern and temporal sequence
    Title: Tyrosine sulfation of CCR5 N-terminal peptide by tyrosylprotein sulfotransferases 1 and 2 follows a discrete pattern and temporal sequence.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The chemokine receptor CCR5 is posttranslationally modified by sulfation of its N-terminal tyrosines; sulfated tyrosines contribute to the binding of CCR5 to MIP-1 alpha, MIP-1 beta, and HIV-1 gp120/CD4 complexes and to the ability of HIV-1 to enter cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-tyrosine sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-tyrosine sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-tyrosine sulfotransferase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process TAS
Traceable Author Statement
more info
  
involved_in peptidyl-tyrosine sulfation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in post-translational protein modification IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
protein-tyrosine sulfotransferase 1
Names
TPST-1
transport and golgi organization 13 homolog A
NP_003587.1
XP_005250699.1
XP_011514936.1
XP_011514937.1
XP_016868215.1
XP_016868216.1
XP_047276912.1
XP_047276913.1
XP_047276914.1
XP_047276915.1
XP_047276916.1
XP_047276918.1
XP_047276919.1
XP_054215199.1
XP_054215200.1
XP_054215201.1
XP_054215202.1
XP_054215203.1
XP_054215204.1
XP_054215205.1
XP_054215206.1
XP_054215207.1
XP_054215208.1
XP_054215209.1
XP_054215210.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003596.4 → NP_003587.1  protein-tyrosine sulfotransferase 1

    See identical proteins and their annotated locations for NP_003587.1

    Status: VALIDATED

    Source sequence(s)
    BC013188
    Consensus CDS
    CCDS5533.1
    UniProtKB/Swiss-Prot
    A4D2M0, O60507, Q6FGM7
    UniProtKB/TrEMBL
    Q75M96
    Related
    ENSP00000302413.5, ENST00000304842.6
    Conserved Domains (1) summary
    pfam13469
    Location:72 → 261
    Sulfotransfer_3; Sulfotransferase family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    66198790..66360443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420959.1 → XP_047276915.1  protein-tyrosine sulfotransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    A4D2M0, O60507, Q6FGM7

  2. XM_047420957.1 → XP_047276913.1  protein-tyrosine sulfotransferase 1 isoform X1

  3. XM_047420960.1 → XP_047276916.1  protein-tyrosine sulfotransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    A4D2M0, O60507, Q6FGM7

  4. XM_047420962.1 → XP_047276918.1  protein-tyrosine sulfotransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    A4D2M0, O60507, Q6FGM7

  5. XM_047420958.1 → XP_047276914.1  protein-tyrosine sulfotransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    A4D2M0, O60507, Q6FGM7

  6. XM_017012726.3 → XP_016868215.1  protein-tyrosine sulfotransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    A4D2M0, O60507, Q6FGM7
    UniProtKB/TrEMBL
    Q75M96
    Conserved Domains (1) summary
    pfam13469
    Location:72 → 261
    Sulfotransfer_3; Sulfotransferase family

  7. XM_017012727.3 → XP_016868216.1  protein-tyrosine sulfotransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    A4D2M0, O60507, Q6FGM7
    UniProtKB/TrEMBL
    Q75M96
    Conserved Domains (1) summary
    pfam13469
    Location:72 → 261
    Sulfotransfer_3; Sulfotransferase family

  8. XM_011516635.4 → XP_011514937.1  protein-tyrosine sulfotransferase 1 isoform X3

    See identical proteins and their annotated locations for XP_011514937.1

    UniProtKB/TrEMBL
    Q75M96
    Conserved Domains (1) summary
    pfam13469
    Location:72 → 261
    Sulfotransfer_3; Sulfotransferase family

  9. XM_047420963.1 → XP_047276919.1  protein-tyrosine sulfotransferase 1 isoform X3

  10. XM_011516634.4 → XP_011514936.1  protein-tyrosine sulfotransferase 1 isoform X3

    See identical proteins and their annotated locations for XP_011514936.1

    UniProtKB/TrEMBL
    Q75M96
    Conserved Domains (1) summary
    pfam13469
    Location:72 → 261
    Sulfotransfer_3; Sulfotransferase family

  11. XM_005250642.4 → XP_005250699.1  protein-tyrosine sulfotransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_005250699.1

    UniProtKB/TrEMBL
    Q75M96
    Conserved Domains (1) summary
    pfam13469
    Location:69 → 257
    Sulfotransfer_3; Sulfotransferase family

  12. XM_047420956.1 → XP_047276912.1  protein-tyrosine sulfotransferase 1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    67420877..67582531
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359230.1 → XP_054215205.1  protein-tyrosine sulfotransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    A4D2M0, O60507, Q6FGM7

  2. XM_054359226.1 → XP_054215201.1  protein-tyrosine sulfotransferase 1 isoform X1

  3. XM_054359231.1 → XP_054215206.1  protein-tyrosine sulfotransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    A4D2M0, O60507, Q6FGM7

  4. XM_054359232.1 → XP_054215207.1  protein-tyrosine sulfotransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    A4D2M0, O60507, Q6FGM7

  5. XM_054359227.1 → XP_054215202.1  protein-tyrosine sulfotransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    A4D2M0, O60507, Q6FGM7

  6. XM_054359228.1 → XP_054215203.1  protein-tyrosine sulfotransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    A4D2M0, O60507, Q6FGM7

  7. XM_054359229.1 → XP_054215204.1  protein-tyrosine sulfotransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    A4D2M0, O60507, Q6FGM7

  8. XM_054359234.1 → XP_054215209.1  protein-tyrosine sulfotransferase 1 isoform X3

  9. XM_054359235.1 → XP_054215210.1  protein-tyrosine sulfotransferase 1 isoform X3

  10. XM_054359233.1 → XP_054215208.1  protein-tyrosine sulfotransferase 1 isoform X3

  11. XM_054359224.1 → XP_054215199.1  protein-tyrosine sulfotransferase 1 isoform X1

  12. XM_054359225.1 → XP_054215200.1  protein-tyrosine sulfotransferase 1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O60507.1 GenPept UniProtKB/Swiss-Prot:O60507

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