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Rab27b RAB27B, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

Gene ID: 84590, updated on 2-Nov-2024

Summary

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Symbol
Rab27bprovided by RGD
Full Name
RAB27B, member RAS oncogene familyprovided by RGD
Primary source
RGD:620114
See related
EnsemblRapid:ENSRNOG00000012176 AllianceGenome:RGD:620114
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including GTPase activity; guanyl ribonucleotide binding activity; and myosin V binding activity. Involved in anterograde axonal protein transport; regulation of exocytosis; and synaptic vesicle endocytosis. Located in apical plasma membrane and zymogen granule membrane. Is active in synaptic vesicle membrane. Orthologous to human RAB27B (RAB27B, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 111.5), Spleen (RPKM 81.5) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rab27b in Genome Data Viewer
Location:
18q12.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (65870230..66069597, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (63597554..63794124, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (68486006..68644595, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482985 Neighboring gene coiled-coil domain containing 68 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC120098183

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RAB27B requirement for stretch-induced exocytosis in bladder umbrella cells. Gallo LI, et al. Am J Physiol Cell Physiol, 2018 Mar 1. PMID 29167152, Free PMC Article
  2. Rab27b is Involved in Lysosomal Exocytosis and Proteolipid Protein Trafficking in Oligodendrocytes. Shen YT, et al. Neurosci Bull, 2016 Aug. PMID 27325508, Free PMC Article
  3. Rab27b localizes to zymogen granules and regulates pancreatic acinar exocytosis. Chen X, et al. Biochem Biophys Res Commun, 2004 Oct 29. PMID 15451418
  4. NADPH oxidase is internalized by clathrin-coated pits and localizes to a Rab27A/B GTPase-regulated secretory compartment in activated macrophages. Ejlerskov P, et al. J Biol Chem, 2012 Feb 10. PMID 22157766, Free PMC Article
  5. Functional involvement of Noc2, a Rab27 effector, in rat parotid acinar cells. Imai A, et al. Arch Biochem Biophys, 2006 Nov 15. PMID 17067543

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RAB27B regulates discoidal- and/or fusiform-shaped vesicle exocytosis in bladder umbrella cells.
    Title: RAB27B requirement for stretch-induced exocytosis in bladder umbrella cells.
  2. The data of this study suggested that Rab27b is involved in myelin biogenesis by regulating PLP transport from late endosomes/lysosomes to the cell membrane in oligodendrocytes.
    Title: Rab27b is Involved in Lysosomal Exocytosis and Proteolipid Protein Trafficking in Oligodendrocytes.
  3. cyt b(558) depends on clathrin for internalization, and in activated macrophages NADPH oxidase occupies a Rab27A/B-regulated secretory compartment
    Title: NADPH oxidase is internalized by clathrin-coated pits and localizes to a Rab27A/B GTPase-regulated secretory compartment in activated macrophages.
  4. Selective modulation of the GTP/GDP switch mechanism of Rab27b impairs synaptic vesicle recycling and suggests that Rab27b, in concert with Rab3a, is involved in synaptic vesicle exocytosis.
    Title: Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis.
  5. Study shows that the Slp1/Rab27B/CRMP-2 complex directly links TrkB to Kinesin-1, and that this association is required for the anterograde transport of TrkB-containing vesicles in axons.
    Title: Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27.
  6. the Rab27B-Slac2-c complex is an important constituent of secretory granule exocytosis in parotid acinar cells
    Title: The small GTPase Rab27B regulates amylase release from rat parotid acinar cells.
  7. These results demonstrate that Rab27b is present on ZGs and plays an important role in regulating acinar exocytosis.
    Title: Rab27b localizes to zymogen granules and regulates pancreatic acinar exocytosis.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GDP binding ISO
Inferred from Sequence Orthology
more info
  
enables GDP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables myosin V binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in anterograde axonal protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in multivesicular body sorting pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of exocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi stack ISO
Inferred from Sequence Orthology
more info
  
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in melanosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in melanosome ISO
Inferred from Sequence Orthology
more info
  
located_in multivesicular body membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synaptic vesicle membrane EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network transport vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in zymogen granule membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ras-related protein Rab-27B
NP_445911.1
XP_006254992.1
XP_017456535.1
XP_038953121.1
XP_038953122.1
XP_038953123.1
XP_038953127.1
XP_063133705.1
XP_063133706.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053459.1 → NP_445911.1  ras-related protein Rab-27B

    See identical proteins and their annotated locations for NP_445911.1

    Status: PROVISIONAL

    Source sequence(s)
    AF325693
    UniProtKB/Swiss-Prot
    Q99P74
    UniProtKB/TrEMBL
    A6IXZ5
    Related
    ENSRNOP00000095120.1, ENSRNOT00000106463.2
    Conserved Domains (1) summary
    cd04127
    Location:6 → 185
    Rab27A; Rab GTPase family 27a (Rab27a)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    65870230..66069597 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097195.2 → XP_038953123.1  ras-related protein Rab-27B isoform X1

    UniProtKB/Swiss-Prot
    Q99P74
    UniProtKB/TrEMBL
    A6IXZ5
    Conserved Domains (1) summary
    cd04127
    Location:6 → 185
    Rab27A; Rab GTPase family 27a (Rab27a)

  2. XM_063277636.1 → XP_063133706.1  ras-related protein Rab-27B isoform X1

    UniProtKB/Swiss-Prot
    Q99P74
    UniProtKB/TrEMBL
    A6IXZ5

  3. XM_063277635.1 → XP_063133705.1  ras-related protein Rab-27B isoform X1

    UniProtKB/Swiss-Prot
    Q99P74
    UniProtKB/TrEMBL
    A6IXZ5

  4. XM_006254930.5 → XP_006254992.1  ras-related protein Rab-27B isoform X1

    See identical proteins and their annotated locations for XP_006254992.1

    UniProtKB/Swiss-Prot
    Q99P74
    UniProtKB/TrEMBL
    A6IXZ5
    Conserved Domains (1) summary
    cd04127
    Location:6 → 185
    Rab27A; Rab GTPase family 27a (Rab27a)

  5. XM_039097193.2 → XP_038953121.1  ras-related protein Rab-27B isoform X1

    UniProtKB/Swiss-Prot
    Q99P74
    UniProtKB/TrEMBL
    A6IXZ5
    Conserved Domains (1) summary
    cd04127
    Location:6 → 185
    Rab27A; Rab GTPase family 27a (Rab27a)

  6. XM_039097194.2 → XP_038953122.1  ras-related protein Rab-27B isoform X1

    UniProtKB/Swiss-Prot
    Q99P74
    UniProtKB/TrEMBL
    A6IXZ5
    Conserved Domains (1) summary
    cd04127
    Location:6 → 185
    Rab27A; Rab GTPase family 27a (Rab27a)

  7. XM_017601046.3 → XP_017456535.1  ras-related protein Rab-27B isoform X2

    UniProtKB/TrEMBL
    A0A8L2Q7R9
    Related
    ENSRNOP00000016369.2, ENSRNOT00000016369.5

  8. XM_039097199.2 → XP_038953127.1  ras-related protein Rab-27B isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99P74.3 GenPept UniProtKB/Swiss-Prot:Q99P74

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