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Strbp spermatid perinuclear RNA binding protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 84476, updated on 10-Oct-2024

Summary

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Official Symbol
Strbpprovided by RGD
Official Full Name
spermatid perinuclear RNA binding proteinprovided by RGD
Primary source
RGD:620673
See related
EnsemblRapid:ENSRNOG00000010150 AllianceGenome:RGD:620673
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Spnr
Summary
Predicted to enable double-stranded RNA binding activity; microtubule binding activity; and single-stranded RNA binding activity. Predicted to be involved in cell differentiation and spermatogenesis. Predicted to act upstream of or within mechanosensory behavior and spermatid development. Predicted to be located in manchette and nucleus. Orthologous to human STRBP (spermatid perinuclear RNA binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 261.2), Adrenal (RPKM 148.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Strbp in Genome Data Viewer
Location:
3q11
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (41738096..41879054, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (21328310..21467753, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (21817680..21956988, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350365 Neighboring gene zinc finger and BTB domain containing 26 Neighboring gene RAB GTPase activating protein 1 Neighboring gene G protein-coupled receptor 21 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC134486087 Neighboring gene ribosomal protein S16 like 1 Neighboring gene uncharacterized LOC120101537

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mice deficient for spermatid perinuclear RNA-binding protein show neurologic, spermatogenic, and sperm morphological abnormalities. Pires-daSilva A, et al. Dev Biol, 2001 May 15. PMID 11336498
  2. Spnr, a murine RNA-binding protein that is localized to cytoplasmic microtubules. Schumacher JM, et al. J Cell Biol, 1995 May. PMID 7744952, Free PMC Article
  3. A new double-stranded RNA-binding protein that interacts with PKR. Coolidge CJ, et al. Nucleic Acids Res, 2000 Mar 15. PMID 10684936, Free PMC Article
  4. Spermatid perinuclear ribonucleic acid-binding protein binds microtubules in vitro and associates with abnormal manchettes in vivo in mice. Schumacher JM, et al. Biol Reprod, 1998 Jul. PMID 9674995
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables tubulin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell motility IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell motility ISO
Inferred from Sequence Orthology
more info
  
involved_in mechanosensory behavior IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mechanosensory behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatid development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within spermatid development ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in manchette IEA
Inferred from Electronic Annotation
more info
  
located_in manchette ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
spermatid perinuclear RNA-binding protein
Names
74 kDa double-stranded RNA-binding protein
double-stranded RNA-binding protein p74
p74

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429552.1 → NP_001416481.1  spermatid perinuclear RNA-binding protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6JET9, D3ZDD7

  2. NM_001429553.1 → NP_001416482.1  spermatid perinuclear RNA-binding protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6JET9, D3ZDD7

  3. NM_001429554.1 → NP_001416483.1  spermatid perinuclear RNA-binding protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6JET9, D3ZDD7

  4. NM_053416.3 → NP_445868.2  spermatid perinuclear RNA-binding protein

    See identical proteins and their annotated locations for NP_445868.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q9JKU6
    UniProtKB/TrEMBL
    A6JET9, D3ZDD7
    Related
    ENSRNOP00000062543.1, ENSRNOT00000066377.4
    Conserved Domains (4) summary
    smart00572
    Location:81 → 334
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    pfam17228
    Location:608 → 667
    SGP; Sulphur globule protein
    cd19909
    Location:384 → 467
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:512 → 575
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    41738096..41879054 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284719.1 → XP_063140789.1  spermatid perinuclear RNA-binding protein isoform X3

  2. XM_039105987.2 → XP_038961915.1  spermatid perinuclear RNA-binding protein isoform X7

    Conserved Domains (4) summary
    cl02675
    Location:8 → 63
    DZF; DZF domain
    pfam17228
    Location:337 → 393
    SGP; Sulphur globule protein
    cd19909
    Location:113 → 196
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:241 → 304
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

  3. XM_039105986.2 → XP_038961914.1  spermatid perinuclear RNA-binding protein isoform X6

    Conserved Domains (4) summary
    cl02675
    Location:1 → 153
    DZF; DZF domain
    pfam17228
    Location:427 → 483
    SGP; Sulphur globule protein
    cd19909
    Location:203 → 286
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:331 → 394
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

  4. XM_063284728.1 → XP_063140798.1  spermatid perinuclear RNA-binding protein isoform X6

  5. XM_063284717.1 → XP_063140787.1  spermatid perinuclear RNA-binding protein isoform X1

  6. XM_063284712.1 → XP_063140782.1  spermatid perinuclear RNA-binding protein isoform X1

  7. XM_063284714.1 → XP_063140784.1  spermatid perinuclear RNA-binding protein isoform X1

  8. XM_063284711.1 → XP_063140781.1  spermatid perinuclear RNA-binding protein isoform X1

  9. XM_063284715.1 → XP_063140785.1  spermatid perinuclear RNA-binding protein isoform X1

  10. XM_063284713.1 → XP_063140783.1  spermatid perinuclear RNA-binding protein isoform X1

  11. XM_063284716.1 → XP_063140786.1  spermatid perinuclear RNA-binding protein isoform X1

  12. XM_063284721.1 → XP_063140791.1  spermatid perinuclear RNA-binding protein isoform X4

  13. XM_063284720.1 → XP_063140790.1  spermatid perinuclear RNA-binding protein isoform X4

  14. XM_063284722.1 → XP_063140792.1  spermatid perinuclear RNA-binding protein isoform X4

  15. XM_039105982.2 → XP_038961910.1  spermatid perinuclear RNA-binding protein isoform X4

    UniProtKB/TrEMBL
    A0A0G2K3L7
    Conserved Domains (4) summary
    smart00572
    Location:81 → 334
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    pfam17228
    Location:608 → 664
    SGP; Sulphur globule protein
    cd19909
    Location:384 → 467
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:512 → 575
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

  16. XM_039105984.2 → XP_038961912.1  spermatid perinuclear RNA-binding protein isoform X4

    UniProtKB/TrEMBL
    A0A0G2K3L7
    Conserved Domains (4) summary
    smart00572
    Location:81 → 334
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    pfam17228
    Location:608 → 664
    SGP; Sulphur globule protein
    cd19909
    Location:384 → 467
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:512 → 575
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

  17. XM_039105985.2 → XP_038961913.1  spermatid perinuclear RNA-binding protein isoform X4

    UniProtKB/TrEMBL
    A0A0G2K3L7
    Conserved Domains (4) summary
    smart00572
    Location:81 → 334
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    pfam17228
    Location:608 → 664
    SGP; Sulphur globule protein
    cd19909
    Location:384 → 467
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:512 → 575
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

  18. XM_063284727.1 → XP_063140797.1  spermatid perinuclear RNA-binding protein isoform X5

  19. XM_063284725.1 → XP_063140795.1  spermatid perinuclear RNA-binding protein isoform X5

  20. XM_063284726.1 → XP_063140796.1  spermatid perinuclear RNA-binding protein isoform X5

    UniProtKB/TrEMBL
    A6JET9, D3ZDD7

  21. XM_008761777.4 → XP_008759999.1  spermatid perinuclear RNA-binding protein isoform X5

    Conserved Domains (4) summary
    smart00572
    Location:81 → 334
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    pfam17228
    Location:608 → 667
    SGP; Sulphur globule protein
    cd19909
    Location:384 → 467
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:512 → 575
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

  22. XM_063284718.1 → XP_063140788.1  spermatid perinuclear RNA-binding protein isoform X2

    Related
    ENSRNOP00000111602.1, ENSRNOT00000138609.1

  23. XM_063284724.1 → XP_063140794.1  spermatid perinuclear RNA-binding protein isoform X5

  24. XM_063284723.1 → XP_063140793.1  spermatid perinuclear RNA-binding protein isoform X5

    UniProtKB/TrEMBL
    A6JET9, D3ZDD7

RNA

  1. XR_591457.4 RNA Sequence

  2. XR_010064705.1 RNA Sequence

  3. XR_010064704.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JKU6.1 GenPept UniProtKB/Swiss-Prot:Q9JKU6

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