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ZNF528 zinc finger protein 528 [ Homo sapiens (human) ]

Gene ID: 84436, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF528provided by HGNC
Official Full Name
zinc finger protein 528provided by HGNC
Primary source
HGNC:HGNC:29384
See related
Ensembl:ENSG00000167555 MIM:615580; AllianceGenome:HGNC:29384
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 4.6), ovary (RPKM 4.2) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF528 in Genome Data Viewer
Location:
19q13.41
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (52397849..52418401)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (55477348..55503081)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52901102..52921654)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:52841280-52841780 Neighboring gene zinc finger protein 610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15046 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15047 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15048 Neighboring gene zinc finger protein 880 Neighboring gene ZNF528 antisense RNA 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:52900414-52901613 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:52923769-52924534 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:52924535-52925300 Neighboring gene developmental pluripotency associated 5 pseudogene 1 Neighboring gene zinc finger protein 534 Neighboring gene DUT pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Exome Sequencing Reveals a Phenotype Modifying Variant in ZNF528 in Primary Osteoporosis With a COL1A2 Deletion. Skarp S, et al. J Bone Miner Res, 2020 Dec. PMID 32722848, Free PMC Article
  2. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2001 Apr 27. PMID 11347906
  3. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Fei T, et al. Proc Natl Acad Sci U S A, 2017 Jun 27. PMID 28611215, Free PMC Article
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article
  5. Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling. Kouranti I, et al. Int J Mol Sci, 2022 May 5. PMID 35563538, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exome Sequencing Reveals a Phenotype Modifying Variant in ZNF528 in Primary Osteoporosis With a COL1A2 Deletion.
    Title: Exome Sequencing Reveals a Phenotype Modifying Variant in ZNF528 in Primary Osteoporosis With a COL1A2 Deletion.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1827, MGC126761, MGC138155

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 528

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032423.3 → NP_115799.2  zinc finger protein 528

    See identical proteins and their annotated locations for NP_115799.2

    Status: VALIDATED

    Source sequence(s)
    AC010332, AL832630, AL833325
    Consensus CDS
    CCDS33091.1
    UniProtKB/Swiss-Prot
    B3KPN4, Q3MIS6, Q86T88, Q96JK0
    Related
    ENSP00000353652.3, ENST00000360465.8
    Conserved Domains (5) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:193 → 628
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:243 → 263
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:255 → 280
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    52397849..52418401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723418.3 → XP_006723481.1  zinc finger protein 528 isoform X1

    See identical proteins and their annotated locations for XP_006723481.1

    Conserved Domains (5) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:277 → 712
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:327 → 347
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:339 → 364
    zf-H2C2_2; Zinc-finger double domain

  2. XM_047439511.1 → XP_047295467.1  zinc finger protein 528 isoform X2

  3. XM_017027365.2 → XP_016882854.1  zinc finger protein 528 isoform X3

    Conserved Domains (3) summary
    COG5048
    Location:131 → 566
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:181 → 201
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:193 → 218
    zf-H2C2_2; Zinc-finger double domain

  4. XM_047439512.1 → XP_047295468.1  zinc finger protein 528 isoform X3

  5. XM_011527394.3 → XP_011525696.1  zinc finger protein 528 isoform X3

    See identical proteins and their annotated locations for XP_011525696.1

    Conserved Domains (3) summary
    COG5048
    Location:131 → 566
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:181 → 201
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:193 → 218
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    55477348..55503081
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322339.1 → XP_054178314.1  zinc finger protein 528 isoform X1

  2. XM_054322338.1 → XP_054178313.1  zinc finger protein 528 isoform X1

  3. XM_054322336.1 → XP_054178311.1  zinc finger protein 528 isoform X1

  4. XM_054322337.1 → XP_054178312.1  zinc finger protein 528 isoform X1

  5. XM_054322340.1 → XP_054178315.1  zinc finger protein 528 isoform X2

  6. XM_054322342.1 → XP_054178317.1  zinc finger protein 528 isoform X3

  7. XM_054322343.1 → XP_054178318.1  zinc finger protein 528 isoform X3

  8. XM_054322341.1 → XP_054178316.1  zinc finger protein 528 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3MIS6.1 GenPept UniProtKB/Swiss-Prot:Q3MIS6

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