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TPS1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 844194, updated on 22-Aug-2024

Summary

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Official Symbol
TPS1
Primary source
TAIR:AT1G78580
Locus tag
AT1G78580
See related
Araport:AT1G78580
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATTPS1; T30F21.9; T30F21_9; trehalose-6-phosphate synthase; TREHALOSE-6-PHOSPHATE SYNTHASE 1
Summary
Encodes an enzyme putatively involved in trehalose biosynthesis. The protein has a trehalose synthase (TPS)-like domain but no trehalose phosphatase (TPP)-like domain. ATTPS1 is able to complement yeast tps1 mutants in vivo. The gene product modulates cell growth but not cell differentiation by determining cell wall deposition and cell division.
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Genomic context

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Location:
chromosome: 1
Exon count:
20
Sequence:
Chromosome: 1; NC_003070.9 (29552340..29560912, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Sodium Bile acid symporter family Neighboring gene ncRNA Neighboring gene rhamnose biosynthesis 1 Neighboring gene ncRNA Neighboring gene NAD(H) kinase 3 Neighboring gene light-regulated zinc finger protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The trehalose 6-phosphate pathway impacts vegetative phase change in Arabidopsis thaliana. Ponnu J, et al. Plant J, 2020 Nov. PMID 32799402
  2. Functional Features of TREHALOSE-6-PHOSPHATE SYNTHASE1, an Essential Enzyme in Arabidopsis. Fichtner F, et al. Plant Cell, 2020 Jun. PMID 32276986, Free PMC Article
  3. Regulation of flowering by trehalose-6-phosphate signaling in Arabidopsis thaliana. Wahl V, et al. Science, 2013 Feb 8. PMID 23393265
  4. AtTPS1-mediated trehalose 6-phosphate synthesis is essential for embryogenic and vegetative growth and responsiveness to ABA in germinating seeds and stomatal guard cells. Gómez LD, et al. Plant J, 2010 Oct. PMID 20659274
  5. Immunogold localization of trehalose-6-phosphate synthase in leaf segments of wild-type and transgenic tobacco plants expressing the AtTPS1 gene from Arabidopsis thaliana. Almeida AM, et al. Protoplasma, 2007. PMID 17111094

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Natural variation of warm temperature-induced raffinose accumulation identifies TREHALOSE-6-PHOSPHATE SYNTHASE 1 as a modulator of thermotolerance.
    Title: Natural variation of warm temperature-induced raffinose accumulation identifies TREHALOSE-6-PHOSPHATE SYNTHASE 1 as a modulator of thermotolerance.
  2. The trehalose 6-phosphate pathway impacts vegetative phase change in Arabidopsis thaliana.
    Title: The trehalose 6-phosphate pathway impacts vegetative phase change in Arabidopsis thaliana.
  3. TPS1 is required for sucrose-induced hypocotyl elongation in light/dark cycles.
    Title: The Energy-Signaling Hub SnRK1 Is Important for Sucrose-Induced Hypocotyl Elongation.
  4. Data suggest that Arabidopsis thaliana exhibits three active trehalose-6-phosphate synthase isoforms: TPS1, TPS2, and TPS4.
    Title: Trehalose-6-phosphate synthase 1 is not the only active TPS in Arabidopsis thaliana.
  5. loss of TPS1 causes extremely late flowering; this suggests TPS1 is required for timely initiation of flowering; findings show the trehalose-6-phosphate pathway affects flowering both in leaves and at the shoot meristem, and integrate TPS1 into the existing genetic framework of flowering-time control
    Title: Regulation of flowering by trehalose-6-phosphate signaling in Arabidopsis thaliana.
  6. TSP1 plays an essential role in regulating the growth of vegetative as well as embryogenic tissue in a mechanism involving ABA and sugar metabolism.
    Title: AtTPS1-mediated trehalose 6-phosphate synthesis is essential for embryogenic and vegetative growth and responsiveness to ABA in germinating seeds and stomatal guard cells.
  7. TPS1 may play a major role in coordinating cell wall biosynthesis and cell division with cellular metabolism during embryo development.
    Title: Delayed embryo development in the ARABIDOPSIS TREHALOSE-6-PHOSPHATE SYNTHASE 1 mutant is associated with altered cell wall structure, decreased cell division and starch accumulation.
  8. It can be expected that TPS1 from tobacco has a relatively high similarity to the TPS of Arabidopsis thaliana.
    Title: Immunogold localization of trehalose-6-phosphate synthase in leaf segments of wild-type and transgenic tobacco plants expressing the AtTPS1 gene from Arabidopsis thaliana.
Submit: New GeneRIF Correction

General gene information

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Homology

NM_001334832.1
NM_001334833.1
NM_001334834.1
NM_106505.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables glycosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within developmental vegetative growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryo development ending in seed dormancy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within long-day photoperiodism, flowering IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within plant-type cell wall biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within root development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sugar mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in trehalose biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within trehalose metabolic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
trehalose-6-phosphate synthase
NP_001319403.1
  • trehalose-6-phosphate synthase (TPS1); CONTAINS InterPro DOMAIN/s: Alpha,alpha-trehalose-phosphate synthase (InterPro:IPR012766), Glycosyl transferase, family 20 (InterPro:IPR001830), Trehalose-phosphatase (InterPro:IPR003337); BEST Arabidopsis thaliana protein match is: trehalose-phosphatase/synthase 2 (TAIR:AT1G16980.1); Has 6189 Blast hits to 3807 proteins in 1021 species: Archae - 45; Bacteria - 1772; Metazoa - 831; Fungi - 808; Plants - 384; Viruses - 0; Other Eukaryotes - 2349 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    29552340..29560912 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001334832.1 → NP_001319403.1  trehalose-6-phosphate synthase [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P93653, Q94K55, Q9SYM4
    UniProtKB/TrEMBL
    A0A178WG51, A0A384L3B9, A0A5S9WVI6, W8PVS8
    Conserved Domains (1) summary
    PLN03064
    Location:1 → 941
    PLN03064; alpha,alpha-trehalose-phosphate synthase (UDP-forming); Provisional

  2. NM_106505.5 → NP_177979.1  trehalose-6-phosphate synthase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_177979.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P93653, Q94K55, Q9SYM4
    UniProtKB/TrEMBL
    A0A178WG51, A0A384L3B9, A0A5S9WVI6, W8PVS8
    Conserved Domains (1) summary
    PLN03064
    Location:1 → 941
    PLN03064; alpha,alpha-trehalose-phosphate synthase (UDP-forming); Provisional

  3. NM_001334833.1 → NP_001322931.1  trehalose-6-phosphate synthase [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P93653, Q94K55, Q9SYM4
    UniProtKB/TrEMBL
    A0A178WG51, A0A384L3B9, A0A5S9WVI6, W8PVS8
    Conserved Domains (1) summary
    PLN03064
    Location:1 → 941
    PLN03064; alpha,alpha-trehalose-phosphate synthase (UDP-forming); Provisional

  4. NM_001334834.1 → NP_001322932.1  trehalose-6-phosphate synthase [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P93653, Q94K55, Q9SYM4
    UniProtKB/TrEMBL
    A0A178WG51, A0A384L3B9, A0A5S9WVI6, W8PVS8
    Conserved Domains (1) summary
    PLN03064
    Location:1 → 941
    PLN03064; alpha,alpha-trehalose-phosphate synthase (UDP-forming); Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SYM4.1

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