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PGM2 Phosphoglucomutase/phosphomannomutase family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 843410, updated on 18-Sep-2024

Summary

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Official Symbol
PGM2
Official Full Name
Phosphoglucomutase/phosphomannomutase family protein
Primary source
TAIR:AT1G70730
Locus tag
AT1G70730
See related
Araport:AT1G70730
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F5A18.9; F5A18_9; phosphoglucomutase 2
Summary
Encodes a cytosolic phosphoglucomutase (PGM). Two Arabidopsis PGM proteins (AT1G70730/PGM2 and AT1G23190/PGM3) have high sequence similarities and redundant functions. Mature plants possessing a single cPGM allele had a major reduction in cPGM activity. Whereas pgm2 and pgm3 single mutants are undistinguishable from the wild type, loss of both PGM2 and PGM3 severely impairs male and female gametophyte development.
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Genomic context

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See PGM2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
19
Sequence:
Chromosome: 1; NC_003070.9 (26668646..26673166, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene glycosyl hydrolase 9B1 Neighboring gene Plant invertase/pectin methylesterase inhibitor superfamily protein Neighboring gene Protein kinase superfamily protein Neighboring gene myosin-binding protein (Protein of unknown function, DUF593)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Loss of cytosolic phosphoglucomutase compromises gametophyte development in Arabidopsis. Egli B, et al. Plant Physiol, 2010 Dec. PMID 20959421, Free PMC Article
  2. Starch synthase 4 is located in the thylakoid membrane and interacts with plastoglobule-associated proteins in Arabidopsis. Gámez-Arjona FM, et al. Plant J, 2014 Oct. PMID 25088399
  3. A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome. Marmagne A, et al. Mol Cell Proteomics, 2007 Nov. PMID 17644812
  4. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
  5. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001160992.1
NM_001160993.2
NM_105741.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoglucomutase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoglucomutase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within gametophyte development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
Phosphoglucomutase/phosphomannomutase family protein
NP_001154464.1
  • Phosphoglucomutase/phosphomannomutase family protein; FUNCTIONS IN: intramolecular transferase activity, phosphotransferases, magnesium ion binding, phosphoglucomutase activity; INVOLVED IN: carbohydrate metabolic process; LOCATED IN: cytosol, nucleus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Alpha-D-phosphohexomutase, conserved site (InterPro:IPR016066), Alpha-D-phosphohexomutase, C-terminal (InterPro:IPR005843), Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III (InterPro:IPR016055), Alpha-D-phosphohexomutase, alpha/beta/alpha domain III (InterPro:IPR005846), Alpha-D-phosphohexomutase, alpha/beta/alpha domain II (InterPro:IPR005845), Alpha-D-phosphohexomutase (InterPro:IPR005841), Alpha-D-phosphohexomutase, alpha/beta/alpha domain I (InterPro:IPR005844); BEST Arabidopsis thaliana protein match is: Phosphoglucomutase/phosphomannomutase family protein (TAIR:AT1G23190.1); Has 6684 Blast hits to 6671 proteins in 2112 species: Archae - 92; Bacteria - 4940; Metazoa - 519; Fungi - 202; Plants - 162; Viruses - 0; Other Eukaryotes - 769 (source: NCBI BLink).
NP_001154465.1
  • Phosphoglucomutase/phosphomannomutase family protein; FUNCTIONS IN: intramolecular transferase activity, phosphotransferases, magnesium ion binding, phosphoglucomutase activity; INVOLVED IN: carbohydrate metabolic process; LOCATED IN: cytosol, nucleus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Alpha-D-phosphohexomutase, conserved site (InterPro:IPR016066), Alpha-D-phosphohexomutase, C-terminal (InterPro:IPR005843), Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III (InterPro:IPR016055), Alpha-D-phosphohexomutase, alpha/beta/alpha domain III (InterPro:IPR005846), Alpha-D-phosphohexomutase, alpha/beta/alpha domain II (InterPro:IPR005845), Alpha-D-phosphohexomutase (InterPro:IPR005841), Alpha-D-phosphohexomutase, alpha/beta/alpha domain I (InterPro:IPR005844); BEST Arabidopsis thaliana protein match is: Phosphoglucomutase/phosphomannomutase family protein (TAIR:AT1G23190.1); Has 6668 Blast hits to 6655 proteins in 2105 species: Archae - 91; Bacteria - 4924; Metazoa - 519; Fungi - 202; Plants - 162; Viruses - 0; Other Eukaryotes - 770 (source: NCBI BLink).
NP_177230.1
  • Phosphoglucomutase/phosphomannomutase family protein; FUNCTIONS IN: intramolecular transferase activity, phosphotransferases, magnesium ion binding, phosphoglucomutase activity; INVOLVED IN: response to cadmium ion, carbohydrate metabolic process; LOCATED IN: cytosol, nucleus, plasma membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Alpha-D-phosphohexomutase, conserved site (InterPro:IPR016066), Alpha-D-phosphohexomutase, C-terminal (InterPro:IPR005843), Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III (InterPro:IPR016055), Alpha-D-phosphohexomutase, alpha/beta/alpha domain III (InterPro:IPR005846), Alpha-D-phosphohexomutase, alpha/beta/alpha domain II (InterPro:IPR005845), Alpha-D-phosphohexomutase (InterPro:IPR005841), Alpha-D-phosphohexomutase, alpha/beta/alpha domain I (InterPro:IPR005844); BEST Arabidopsis thaliana protein match is: Phosphoglucomutase/phosphomannomutase family protein (TAIR:AT1G23190.1); Has 8013 Blast hits to 8000 proteins in 2264 species: Archae - 118; Bacteria - 6090; Metazoa - 518; Fungi - 215; Plants - 166; Viruses - 0; Other Eukaryotes - 906 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    26668646..26673166 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001160993.2 → NP_001154465.1  Phosphoglucomutase/phosphomannomutase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001154465.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178W3C5, A0A5S9WT56, F4I6W4
    Conserved Domains (2) summary
    cd03085
    Location:86 → 662
    PGM1; Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction, ...
    PLN02307
    Location:77 → 662
    PLN02307; phosphoglucomutase

  2. NM_105741.4 → NP_177230.1  Phosphoglucomutase/phosphomannomutase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_177230.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9SGC1
    UniProtKB/TrEMBL
    A0A178W3C5, A0A5S9WT56, A0A654EMU1, Q0WN31
    Conserved Domains (1) summary
    PLN02307
    Location:1 → 585
    PLN02307; phosphoglucomutase

  3. NM_001160992.1 → NP_001154464.1  Phosphoglucomutase/phosphomannomutase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001154464.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178W3C5, A0A5S9WT56, F4I6W3
    Conserved Domains (2) summary
    cd03085
    Location:29 → 605
    PGM1; Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction, ...
    PLN02307
    Location:15 → 605
    PLN02307; phosphoglucomutase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SGC1.1

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