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RECK reversion inducing cysteine rich protein with kazal motifs [ Homo sapiens (human) ]

Gene ID: 8434, updated on 3-Apr-2024

Summary

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Official Symbol
RECKprovided by HGNC
Official Full Name
reversion inducing cysteine rich protein with kazal motifsprovided by HGNC
Primary source
HGNC:HGNC:11345
See related
Ensembl:ENSG00000122707 MIM:605227; AllianceGenome:HGNC:11345
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ST15
Summary
The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Expression
Ubiquitous expression in gall bladder (RPKM 6.7), endometrium (RPKM 6.4) and 24 other tissues See more
Orthologs
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Genomic context

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See RECK in Genome Data Viewer
Location:
9p13.3
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (36036913..36124455)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (36058906..36146459)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (36036910..36124452)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily S member 1 pseudogene Neighboring gene olfactory receptor family 2 subfamily AM member 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19885 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19886 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19887 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28344 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36102296-36102796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19888 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19889 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28345 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28346 Neighboring gene GLI pathogenesis related 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:36161748-36162328 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:36162329-36162909 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28347 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36166491-36166991 Neighboring gene calicin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. RECK gene polymorphisms in hepatitis B-related hepatocellular carcinoma: A case-control study. Said EM, et al. Arab J Gastroenterol, 2022 Aug. PMID 35941073
  2. RECK Variants are Associated with Clinicopathological Features and Decreased Susceptibility in Mexican Patients with Colorectal Cancer. María Márquez-González R, et al. Tohoku J Exp Med, 2022 Jun 8. PMID 35444107
  3. Methylation degree of metalloproteinase inhibitor RECK gene: Links to RECK protein level and hepatocellular carcinoma in chronic HCV infection patients. Abo El-Khair SM, et al. J Biochem Mol Toxicol, 2021 Oct. PMID 34392581
  4. Two RECK Splice Variants (Long and Short) Are Differentially Expressed in Patients with Stable and Unstable Coronary Artery Disease: A Pilot Study. Vancheri C, et al. Genes (Basel), 2021 Jun 19. PMID 34205376, Free PMC Article
  5. Reversion inducing cysteine rich protein with Kazal motifs and cardiovascular diseases: The RECKlessness of adverse remodeling. Russell JJ, et al. Cell Signal, 2021 Jul. PMID 33781845, Free PMC Article

See all (173) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of RECK as a protective prognostic indicator and a tumor suppressor through regulation of the ERK/MAPK signaling pathway in gastric cancer.
    Title: Identification of RECK as a protective prognostic indicator and a tumor suppressor through regulation of the ERK/MAPK signaling pathway in gastric cancer.
  2. [miR-181c promotes the migration and angiogenesis of human A549 cells via targeting inhibition of reversion-inducing cysteine-rich protein with Kazal motifs (RECK)].
    Title: [miR-181c promotes the migration and angiogenesis of human A549 cells via targeting inhibition of reversion-inducing cysteine-rich protein with Kazal motifs (RECK)].
  3. RECK gene polymorphisms in hepatitis B-related hepatocellular carcinoma: A case-control study.
    Title: RECK gene polymorphisms in hepatitis B-related hepatocellular carcinoma: A case-control study.
  4. Mycoplasma pneumoniae downregulates RECK to promote matrix metalloproteinase-9 secretion by bronchial epithelial cells.
    Title: Mycoplasma pneumoniae downregulates RECK to promote matrix metalloproteinase-9 secretion by bronchial epithelial cells.
  5. RECK Variants are Associated with Clinicopathological Features and Decreased Susceptibility in Mexican Patients with Colorectal Cancer.
    Title: RECK Variants are Associated with Clinicopathological Features and Decreased Susceptibility in Mexican Patients with Colorectal Cancer.
  6. Methylation degree of metalloproteinase inhibitor RECK gene: Links to RECK protein level and hepatocellular carcinoma in chronic HCV infection patients.
    Title: Methylation degree of metalloproteinase inhibitor RECK gene: Links to RECK protein level and hepatocellular carcinoma in chronic HCV infection patients.
  7. Reversion inducing cysteine rich protein with Kazal motifs and cardiovascular diseases: The RECKlessness of adverse remodeling.
    Title: Reversion inducing cysteine rich protein with Kazal motifs and cardiovascular diseases: The RECKlessness of adverse remodeling.
  8. MiR-590-5p regulates cell proliferation, apoptosis, migration and invasion in oral squamous cell carcinoma by targeting RECK.
    Title: MiR-590-5p regulates cell proliferation, apoptosis, migration and invasion in oral squamous cell carcinoma by targeting RECK.
  9. Two RECK Splice Variants (Long and Short) Are Differentially Expressed in Patients with Stable and Unstable Coronary Artery Disease: A Pilot Study.
    Title: Two RECK Splice Variants (Long and Short) Are Differentially Expressed in Patients with Stable and Unstable Coronary Artery Disease: A Pilot Study.
  10. Reversion-inducing cysteine-rich protein with Kazal motifs and MT1-MMP promote the formation of robust fibrillin fibers.
    Title: Reversion-inducing cysteine-rich protein with Kazal motifs and MT1-MMP promote the formation of robust fibrillin fibers.
Submit: New GeneRIF Correction See all GeneRIFs (155)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Wnt-protein binding IEA
Inferred from Electronic Annotation
more info
  
enables coreceptor activity IEA
Inferred from Electronic Annotation
more info
  
enables endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metalloendopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in blood vessel maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in embryo implantation IEA
Inferred from Electronic Annotation
more info
  
involved_in embryonic forelimb morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of metalloendopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of metalloendopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of establishment of blood-brain barrier IEA
Inferred from Electronic Annotation
more info
  
involved_in sprouting angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Wnt signalosome IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
reversion-inducing cysteine-rich protein with Kazal motifs
Names
membrane-anchored glycoprotein (metastasis and invasion)
suppression of tumorigenicity 15 (reversion-inducing-cysteine-rich protein with kazal motifs)
suppression of tumorigenicity 5 (reversion-inducing-cysteine-rich protein with kazal motifs)
suppressor of tumorigenicity 15 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316345.2 → NP_001303274.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains two alternate exons in the 5' end compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK292653, BC050306
    UniProtKB/TrEMBL
    A8K9D8
    Conserved Domains (2) summary
    pfam14828
    Location:674 → 739
    Amnionless
    cl28910
    Location:505 → 571
    MFS; Major Facilitator Superfamily

  2. NM_001316346.2 → NP_001303275.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate 3'-most exon in place of the last 13 exons compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK292653, AL138834, BC060806, BX393623, CA431378
    UniProtKB/TrEMBL
    Q6P9E2

  3. NM_001316347.2 → NP_001303276.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate 3'-most exon in place of the last 13 exons compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK292653, BC060806, CA431378, JQ756320
    UniProtKB/TrEMBL
    Q6P9E2

  4. NM_001316348.2 → NP_001303277.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate 3'-most exon in place of the last 13 exons compared to variant 1. The resulting isoform (5) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK292653, BC060806, CA431378
    UniProtKB/TrEMBL
    Q6P9E2
    Related
    ENST00000479053.1

  5. NM_021111.3 → NP_066934.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform 1 precursor

    See identical proteins and their annotated locations for NP_066934.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK292653, BC050306, D50406
    Consensus CDS
    CCDS6597.1
    UniProtKB/Swiss-Prot
    B2RNS1, O95980, Q5W0K6, Q8WX37
    UniProtKB/TrEMBL
    A8K9D8
    Related
    ENSP00000367202.3, ENST00000377966.4
    Conserved Domains (2) summary
    pfam03137
    Location:633 → 658
    OATP; Organic Anion Transporter Polypeptide (OATP) family
    pfam14828
    Location:802 → 886
    Amnionless; Amnionless

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    36036913..36124455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015207.2 → XP_016870696.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform X1

    UniProtKB/TrEMBL
    A8K9D8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    36058906..36146459
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054363985.1 → XP_054219960.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95980.1 GenPept UniProtKB/Swiss-Prot:O95980

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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