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ELOF1 elongation factor 1 [ Homo sapiens (human) ]

Gene ID: 84337, updated on 5-Mar-2024

Summary

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Official Symbol
ELOF1provided by HGNC
Official Full Name
elongation factor 1provided by HGNC
Primary source
HGNC:HGNC:28691
See related
Ensembl:ENSG00000130165 MIM:619818; AllianceGenome:HGNC:28691
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ELF1
Summary
Predicted to enable RNA polymerase II complex binding activity. Predicted to be involved in epigenetic maintenance of chromatin in transcription-competent conformation and transcription elongation from RNA polymerase II promoter. Predicted to be located in nucleus. Predicted to be part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 39.1), prostate (RPKM 12.1) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
19p13.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (11553046..11559230, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (11680553..11686741, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11663861..11670045, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ECSIT signaling integrator Neighboring gene ribosomal protein S12 pseudogene 32 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10117 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10118 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11648637-11649582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10119 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14022 Neighboring gene calponin 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11662408-11663379 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14024 Neighboring gene Sharpr-MPRA regulatory region 7075 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10120 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14025 Neighboring gene uncharacterized LOC124904638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11687946-11688558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11688559-11689170 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10121 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14027 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:11692934-11693099 Neighboring gene acid phosphatase 5, tartrate resistant Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14029 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene 76

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability. Geijer ME, et al. Nat Cell Biol, 2021 Jun. PMID 34108662, Free PMC Article
  2. Identification and characterization of Elf1, a conserved transcription elongation factor in Saccharomyces cerevisiae. Prather D, et al. Mol Cell Biol, 2005 Nov. PMID 16260625, Free PMC Article
  3. ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation. van der Weegen Y, et al. Nat Cell Biol, 2021 Jun. PMID 34108663, Free PMC Article
  4. Cell-free cotranslation and selection using in vitro virus for high-throughput analysis of protein-protein interactions and complexes. Miyamoto-Sato E, et al. Genome Res, 2005 May. PMID 15867431, Free PMC Article
  5. A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. Tsang HT, et al. Genomics, 2006 Sep. PMID 16730941

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation.
    Title: ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation.
  2. Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability.
    Title: Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase II complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in transcription elongation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of transcription elongation factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transcription elongation factor 1 homolog
Names
ELF1 homolog, elongation factor 1
elongation factor 1 homolog (ELF1, S. cerevisiae)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363673.3 → NP_001350602.2  transcription elongation factor 1 homolog

    Status: VALIDATED

    Source sequence(s)
    AC008481
    Consensus CDS
    CCDS12264.1
    UniProtKB/Swiss-Prot
    P60002, Q8R1J7, Q96II4
    UniProtKB/TrEMBL
    K7EPC8
    Related
    ENSP00000465765.2, ENST00000587806.5
    Conserved Domains (1) summary
    pfam05129
    Location:20 → 80
    Elf1; Transcription elongation factor Elf1 like

  2. NM_001363674.4 → NP_001350603.2  transcription elongation factor 1 homolog

    Status: VALIDATED

    Source sequence(s)
    AC008481, AC009001
    Consensus CDS
    CCDS12264.1
    UniProtKB/Swiss-Prot
    P60002, Q8R1J7, Q96II4
    UniProtKB/TrEMBL
    K7EPC8
    Conserved Domains (1) summary
    pfam05129
    Location:20 → 80
    Elf1; Transcription elongation factor Elf1 like

  3. NM_001363675.4 → NP_001350604.2  transcription elongation factor 1 homolog

    Status: VALIDATED

    Source sequence(s)
    AC008481, AC009001
    Consensus CDS
    CCDS12264.1
    UniProtKB/Swiss-Prot
    P60002, Q8R1J7, Q96II4
    UniProtKB/TrEMBL
    K7EPC8
    Conserved Domains (1) summary
    pfam05129
    Location:20 → 80
    Elf1; Transcription elongation factor Elf1 like

  4. NM_032377.4 → NP_115753.1  transcription elongation factor 1 homolog

    See identical proteins and their annotated locations for NP_115753.1

    Status: VALIDATED

    Source sequence(s)
    AC008481, BG718042
    Consensus CDS
    CCDS12264.1
    UniProtKB/Swiss-Prot
    P60002, Q8R1J7, Q96II4
    UniProtKB/TrEMBL
    K7EPC8
    Related
    ENSP00000252445.3, ENST00000252445.8
    Conserved Domains (1) summary
    pfam05129
    Location:20 → 80
    Elf1; Transcription elongation factor Elf1 like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    11553046..11559230 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    11680553..11686741 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P60002.1 GenPept UniProtKB/Swiss-Prot:P60002

Gene LinkOut

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