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HPR hydroxypyruvate reductase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 843129, updated on 18-Sep-2024

Summary

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Official Symbol
HPR
Official Full Name
hydroxypyruvate reductase
Primary source
TAIR:AT1G68010
Locus tag
AT1G68010
See related
Araport:AT1G68010
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATHPR1; hydroxypyruvate reductase
Summary
Encodes hydroxypyruvate reductase.
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Genomic context

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See HPR in Genome Data Viewer
Location:
chromosome: 1
Exon count:
13
Sequence:
Chromosome: 1; NC_003070.9 (25493193..25496053)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene phosphatidylinositol synthase 1 Neighboring gene UDP-Glycosyltransferase / trehalose-phosphatase family protein Neighboring gene RING/FYVE/PHD zinc finger superfamily protein Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Cytosolic Bypass and G6P Shunt in Plants Lacking Peroxisomal Hydroxypyruvate Reductase. Li J, et al. Plant Physiol, 2019 Jun. PMID 30886114, Free PMC Article
  2. Hydroxypyruvate reductase with a carboxy-terminal targeting signal to microbodies is expressed in Arabidopsis. Mano S, et al. Plant Cell Physiol, 1997 Apr. PMID 9177031
  3. Shoot-specific down-regulation of protein farnesyltransferase (alpha-subunit) for yield protection against drought in canola. Wang Y, et al. Mol Plant, 2009 Jan. PMID 19529821, Free PMC Article
  4. Fatty acid beta-oxidation in germinating Arabidopsis seeds is supported by peroxisomal hydroxypyruvate reductase when malate dehydrogenase is absent. Pracharoenwattana I, et al. Plant Mol Biol, 2010 Jan. PMID 19812894
  5. Peroxisomal hydroxypyruvate reductase is not essential for photorespiration in Arabidopsis but its absence causes an increase in the stoichiometry of photorespiratory CO2 release. Cousins AB, et al. Photosynth Res, 2011 Sep. PMID 21567290

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Cytosolic Bypass and G6P Shunt in Plants Lacking Peroxisomal Hydroxypyruvate Reductase.
    Title: A Cytosolic Bypass and G6P Shunt in Plants Lacking Peroxisomal Hydroxypyruvate Reductase.
  2. Elimination of both HPR and PMDH in peroxisomes causes a slight decrease in the rates of photosynthesis under photorespiratory conditions. [HPR1]
    Title: Peroxisomal hydroxypyruvate reductase is not essential for photorespiration in Arabidopsis but its absence causes an increase in the stoichiometry of photorespiratory CO2 release.
  3. The results indicate that HPR can oxidise NADH at sufficient rate in the absence of PMDH to support beta-oxidation and hence seed germination.
    Title: Fatty acid beta-oxidation in germinating Arabidopsis seeds is supported by peroxisomal hydroxypyruvate reductase when malate dehydrogenase is absent.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001198420.1
NM_001334339.1
NM_105471.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables hydroxypyruvate reductase (NADH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydroxypyruvate reductase (NADH) activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables poly(U) RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to light stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to water deprivation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in oxidative photosynthetic carbon pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within photorespiration TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in apoplast HDA PubMed 
located_in chloroplast HDA PubMed 
located_in cytosol HDA PubMed 
located_in mitochondrion HDA PubMed 
located_in peroxisome HDA PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
hydroxypyruvate reductase
NP_001185349.1
  • hydroxypyruvate reductase (HPR); CONTAINS InterPro DOMAIN/s: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain (InterPro:IPR006139), D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding (InterPro:IPR006140), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: D-3-phosphoglycerate dehydrogenase (TAIR:AT3G19480.1).
NP_176968.1
  • hydroxypyruvate reductase (HPR); FUNCTIONS IN: glycerate dehydrogenase activity, poly(U) RNA binding; INVOLVED IN: photorespiration; LOCATED IN: apoplast, chloroplast, peroxisome; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain (InterPro:IPR006139), D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding (InterPro:IPR006140), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: D-3-phosphoglycerate dehydrogenase (TAIR:AT3G19480.1); Has 27648 Blast hits to 27644 proteins in 2724 species: Archae - 466; Bacteria - 17022; Metazoa - 727; Fungi - 1147; Plants - 556; Viruses - 5; Other Eukaryotes - 7725 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    25493193..25496053
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_105471.4 → NP_176968.1  hydroxypyruvate reductase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_176968.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DHJ0, F4HVJ9, O04213, Q9C9W5
    UniProtKB/TrEMBL
    A0A178WM81, A0A5S9WQL9, A0A654ELZ9
    Conserved Domains (1) summary
    PLN02306
    Location:1 → 386
    PLN02306; hydroxypyruvate reductase

  2. NM_001198420.1 → NP_001185349.1  hydroxypyruvate reductase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001185349.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9WQL9, A0A654ELZ9
    Conserved Domains (2) summary
    PLN02306
    Location:1 → 387
    PLN02306; hydroxypyruvate reductase
    COG1052
    Location:88 → 357
    LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]

  3. NM_001334339.1 → NP_001320607.1  hydroxypyruvate reductase [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8ANC0, A0A5S9WQL9, A0A654ELZ9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9C9W5.1

Gene LinkOut

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