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UTP23 UTP23 small subunit processome component [ Homo sapiens (human) ]

Gene ID: 84294, updated on 23-Mar-2024

Summary

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Official Symbol
UTP23provided by HGNC
Official Full Name
UTP23 small subunit processome componentprovided by HGNC
Primary source
HGNC:HGNC:28224
See related
Ensembl:ENSG00000147679 AllianceGenome:HGNC:28224
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C8orf53
Summary
Enables mRNA 3'-UTR binding activity and mRNA 5'-UTR binding activity. Predicted to be involved in rRNA processing. Predicted to act upstream of or within endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Implicated in colorectal adenocarcinoma. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 6.0), ovary (RPKM 5.7) and 25 other tissues See more
Orthologs
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Genomic context

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See UTP23 in Genome Data Viewer
Location:
8q24.11
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (116766524..116774684)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (117894649..117917286)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (117778763..117786923)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27827 Neighboring gene uncharacterized LOC105375713 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27828 Neighboring gene eukaryotic translation initiation factor 3 subunit H Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:117690347-117691260 Neighboring gene NANOG hESC enhancer GRCh37_chr8:117702562-117703067 Neighboring gene NANOG hESC enhancer GRCh37_chr8:117742295-117742846 Neighboring gene uncharacterized LOC124902006 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27830 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27831 Neighboring gene uncharacterized LOC112268030 Neighboring gene RAD21 cohesin complex component Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19473 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19474 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27832 Neighboring gene RAD21 antisense RNA 1 Neighboring gene microRNA 3610

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Down-regulation of UTP23 promotes paclitaxel resistance and predicts poorer prognosis in ovarian cancer. Fu Z, et al. Pathol Res Pract, 2019 Nov. PMID 31540773
  2. The PINc domain protein Utp24, a putative nuclease, is required for the early cleavage steps in 18S rRNA maturation. Bleichert F, et al. Proc Natl Acad Sci U S A, 2006 Jun 20. PMID 16769905, Free PMC Article
  3. Utp23p is required for dissociation of snR30 small nucleolar RNP from preribosomal particles. Hoareau-Aveilla C, et al. Nucleic Acids Res, 2012 Apr. PMID 22180534, Free PMC Article
  4. The ribosome biogenesis factor yUtp23/hUTP23 coordinates key interactions in the yeast and human pre-40S particle and hUTP23 contains an essential PIN domain. Wells GR, et al. Nucleic Acids Res, 2017 May 5. PMID 28082392, Free PMC Article
  5. Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Takagi M, et al. Cell, 2005 Oct 7. PMID 16213212

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cytoplasmic expression of UTP23 promotes colorectal cancer progression.
    Title: Cytoplasmic expression of UTP23 promotes colorectal cancer progression.
  2. UTP23 Is a Promising Prognostic Biomarker and Is Associated with Immune Infiltration in Breast Cancer.
    Title: UTP23 Is a Promising Prognostic Biomarker and Is Associated with Immune Infiltration in Breast Cancer.
  3. UTP23 Functions in Breast Cancer Progression and Predicts Poor Prognosis of Luminal a Breast Cancer.
    Title: UTP23 Functions in Breast Cancer Progression and Predicts Poor Prognosis of Luminal a Breast Cancer.
  4. Our findings elucidated a previously unknown function for UTP23 in regulating paclitaxel sensitivity and UTP23 could serve as a potential prognostic predictor for ovarian cancer
    Title: Down-regulation of UTP23 promotes paclitaxel resistance and predicts poorer prognosis in ovarian cancer.
  5. yUtp23/hUTP23 could therefore be central to the coordinated integration and release of ES6 binding factors and likely plays a pivotal role in remodeling this pre-rRNA region in both yeast and humans. Finally, studies using RNAi-rescue systems in human cells revealed that intact PIN domain and Zinc finger motifs in human hUTP23 are essential for 18S rRNA maturation.
    Title: The ribosome biogenesis factor yUtp23/hUTP23 coordinates key interactions in the yeast and human pre-40S particle and hUTP23 contains an essential PIN domain.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC14595

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA 5'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small ribosomal subunit rRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
rRNA-processing protein UTP23 homolog
Names
UTP23, small subunit (SSU) processome component, homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032334.3 → NP_115710.2  rRNA-processing protein UTP23 homolog

    See identical proteins and their annotated locations for NP_115710.2

    Status: VALIDATED

    Source sequence(s)
    AC087350, AK315770, AP002905, BP231814
    Consensus CDS
    CCDS6320.1
    UniProtKB/Swiss-Prot
    B2RE25, Q96NJ8, Q9BRU9
    Related
    ENSP00000308332.2, ENST00000309822.7
    Conserved Domains (1) summary
    cd09866
    Location:2 → 148
    PIN_Fcf1-Utp23-H; PIN domain of rRNA-processing protein Fcf1- and Utp23-like homologs found in eukaryotes except fungi

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    116766524..116774684
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    117894649..117917286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361351.1 → XP_054217326.1  rRNA-processing protein UTP23 homolog isoform X1

    UniProtKB/Swiss-Prot
    B2RE25, Q96NJ8, Q9BRU9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BRU9.2 GenPept UniProtKB/Swiss-Prot:Q9BRU9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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