GAD2 glutamate decarboxylase 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: GAD2
Official Full Name: glutamate decarboxylase 2
Primary source: TAIR:AT1G65960
Locus tag: AT1G65960
See related: Araport:AT1G65960
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F12P19.12; F12P19_12; glutamate decarboxylase 2; GLUTAMATE DECARBOXYLASE 2
Summary: glutamate decarboxylase (GAD2)
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Genomic context

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See GAD2 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 5

Sequence:: Chromosome: 1; NC_003070.9 (24551807..24557730)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GABA signalling modulates stomatal opening to enhance plant water use efficiency and drought resilience.
Title: GABA signalling modulates stomatal opening to enhance plant water use efficiency and drought resilience.

Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Orthologs from OrthoDB

NM_001124084.1

Supported by ESTs:

NM_001334228.1

Supported by ESTs:

NM_001334229.1

Supported by ESTs:

NM_105268.7

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables calmodulin binding	TAS Traceable Author Statement more info	PubMed
enables glutamate decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within glutamate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glutamate metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: glutamate decarboxylase 2

NP_001117556.1

glutamate decarboxylase 2 (GAD2); CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Pyridoxal phosphate-dependent decarboxylase (InterPro:IPR002129), Glutamate decarboxylase (InterPro:IPR010107), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421); BEST Arabidopsis thaliana protein match is: glutamate decarboxylase (TAIR:AT5G17330.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NP_001319328.1

glutamate decarboxylase 2 (GAD2); CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Pyridoxal phosphate-dependent decarboxylase (InterPro:IPR002129), Glutamate decarboxylase (InterPro:IPR010107), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421); BEST Arabidopsis thaliana protein match is: glutamate decarboxylase (TAIR:AT5G17330.1); Has 2686 Blast hits to 2683 proteins in 834 species: Archae - 189; Bacteria - 1522; Metazoa - 142; Fungi - 352; Plants - 304; Viruses - 2; Other Eukaryotes - 175 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

24551807..24557730

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001334228.1 → NP_001319328.1 glutamate decarboxylase 2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

Q56W28
NM_001334229.1 → NP_001320515.1 glutamate decarboxylase 2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

Q56W28
NM_001124084.1 → NP_001117556.1 glutamate decarboxylase 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001117556.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q42472, Q8RXH0, Q944L6

UniProtKB/TrEMBL

A0A178WE81, A0A5S9WSI3, A0A7G2E4E0

Conserved Domains (1) summary

TIGR01788
Location:17 → 444

Glu-decarb-GAD; glutamate decarboxylase
NM_105268.7 → NP_176771.2 glutamate decarboxylase 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_176771.2

Status: REVIEWED

UniProtKB/TrEMBL

Q56W28

Conserved Domains (1) summary

cl18945
Location:1 → 315

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...