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ZDHHC16 zinc finger DHHC-type palmitoyltransferase 16 [ Homo sapiens (human) ]

Gene ID: 84287, updated on 3-Apr-2024

Summary

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Official Symbol
ZDHHC16provided by HGNC
Official Full Name
zinc finger DHHC-type palmitoyltransferase 16provided by HGNC
Primary source
HGNC:HGNC:20714
See related
Ensembl:ENSG00000171307 MIM:616750; AllianceGenome:HGNC:20714
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APH2; DHHC-16
Summary
Enables palmitoyltransferase activity. Involved in protein palmitoylation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta (RPKM 10.0), lung (RPKM 9.7) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
10q24.1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (97446175..97457370)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (98326355..98337553)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (99205932..99217127)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr10:99186899-99187121 Neighboring gene phosphoglycerate mutase 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:99204892-99205472 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:99205473-99206052 Neighboring gene exosome component 1 Neighboring gene MMS19 homolog, cytosolic iron-sulfur assembly component Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:99257304-99257834 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2679 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2680 Neighboring gene ubiquitin domain containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:99277050-99277878 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:99301395-99302007 Neighboring gene uncharacterized LOC124902488 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:99302008-99302619 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:99311139-99311639 Neighboring gene NANOG hESC enhancer GRCh37_chr10:99313431-99313932

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of human Aph2 gene, involved in AP-1 regulation by interaction with JAB1. Zhang F, et al. Biochim Biophys Acta, 2006 Nov-Dec. PMID 17123647
  2. SETD2 Palmitoylation Mediated by ZDHHC16 in Epidermal Growth Factor Receptor-Mutated Glioblastoma Promotes Ionizing Radiation-Induced DNA Damage. Fan X, et al. Int J Radiat Oncol Biol Phys, 2022 Jul 1. PMID 35192890
  3. Aph2, a protein with a zf-DHHC motif, interacts with c-Abl and has pro-apoptotic activity. Li B, et al. J Biol Chem, 2002 Aug 9. PMID 12021275
  4. Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade. Abrami L, et al. Elife, 2017 Aug 15. PMID 28826475, Free PMC Article
  5. Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy. Zhou T, et al. Proc Natl Acad Sci U S A, 2015 Dec 22. PMID 26644582, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. METTL3-mediated m6A modification enhances ZDHHC16 expression in nonsmall- cell lung cancer patients, attenuating ferroptosis by suppressing CREB ubiquitination.
    Title: METTL3-mediated m6A modification enhances ZDHHC16 expression in nonsmall- cell lung cancer patients, attenuating ferroptosis by suppressing CREB ubiquitination.
  2. SETD2 Palmitoylation Mediated by ZDHHC16 in Epidermal Growth Factor Receptor-Mutated Glioblastoma Promotes Ionizing Radiation-Induced DNA Damage.
    Title: SETD2 Palmitoylation Mediated by ZDHHC16 in Epidermal Growth Factor Receptor-Mutated Glioblastoma Promotes Ionizing Radiation-Induced DNA Damage.
  3. human ZDHHC6, which modifies key proteins of the endoplasmic reticulum, is controlled by an upstream palmitoyltransferase, ZDHHC16, revealing the first palmitoylation cascade.
    Title: Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade.
  4. APH2 contains a zf-DHHC domain (148-210aa), which is involved in protein-protein or protein-DNA interaction.
    Title: Molecular cloning and characterization of human Aph2 gene, involved in AP-1 regulation by interaction with JAB1.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC2993

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-cysteine S-palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in eye development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in heart development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein palmitoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in telencephalon development ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
palmitoyltransferase ZDHHC16
Names
Abl-philin 2
probable palmitoyltransferase ZDHHC16
zinc finger DHHC domain-containing protein 16
zinc finger DHHC-type containing 16
zinc finger, DHHC domain containing 16
NP_001274732.1
NP_001274733.1
NP_115703.2
NP_932160.1
NP_932161.1
NP_932162.1
NP_932163.1
XP_006718087.1
XP_016872255.1
XP_016872256.1
XP_016872257.1
XP_016872258.1
XP_016872260.1
XP_024304001.1
XP_047281793.1
XP_047281794.1
XP_047281795.1
XP_047281796.1
XP_047281797.1
XP_047281798.1
XP_054222889.1
XP_054222890.1
XP_054222891.1
XP_054222892.1
XP_054222893.1
XP_054222894.1
XP_054222895.1
XP_054222896.1
XP_054222897.1
XP_054222898.1
XP_054222899.1
XP_054222900.1
XP_054222901.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287803.2 → NP_001274732.1  palmitoyltransferase ZDHHC16 isoform 5

    See identical proteins and their annotated locations for NP_001274732.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice site in the 3' coding region, compared to variant 5. It encodes isoform 5, which is shorter than isoform 1.
    Source sequence(s)
    AK297962, BC008074, BM678689, DC399731
    UniProtKB/TrEMBL
    B4DNL2, H0Y6E9
    Conserved Domains (1) summary
    pfam01529
    Location:156 → 231
    DHHC; DHHC palmitoyltransferase

  2. NM_001287804.2 → NP_001274733.1  palmitoyltransferase ZDHHC16 isoform 6

    See identical proteins and their annotated locations for NP_001274733.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks three exons in the central and 3' coding regions and uses an alternate in-frame splice site in the 3' coding region, compared to variant 5. It encodes isoform 6, which is shorter than isoform 1.
    Source sequence(s)
    BC008074, BC033157, BM678689, BX353685
    Consensus CDS
    CCDS73176.1
    UniProtKB/TrEMBL
    B1AMU0
    Related
    ENSP00000359883.4, ENST00000370846.8
    Conserved Domains (1) summary
    cl19890
    Location:156 → 185
    DHHC; DHHC palmitoyltransferase

  3. NM_032327.4 → NP_115703.2  palmitoyltransferase ZDHHC16 isoform 1

    See identical proteins and their annotated locations for NP_115703.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 5. Variants 1 and 5 encode the same isoform (1), which is the longest isoform.
    Source sequence(s)
    BC012830, BM678689
    Consensus CDS
    CCDS7460.1
    UniProtKB/Swiss-Prot
    D3DR52, D3DR53, D3DR54, Q5JTG7, Q5JTH0, Q8N4Z6, Q8WY84, Q969W1, Q9BSV3
    UniProtKB/TrEMBL
    H0Y6E9
    Related
    ENSP00000359891.3, ENST00000370854.7
    Conserved Domains (1) summary
    pfam01529
    Location:156 → 305
    DHHC; DHHC palmitoyltransferase

  4. NM_198043.3 → NP_932160.1  palmitoyltransferase ZDHHC16 isoform 2

    See identical proteins and their annotated locations for NP_932160.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 5. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AF258563, BM678689, DC399731
    Consensus CDS
    CCDS7461.1
    UniProtKB/TrEMBL
    H0Y6E9
    Related
    ENSP00000345383.4, ENST00000352634.8
    Conserved Domains (1) summary
    pfam01529
    Location:156 → 289
    DHHC; DHHC palmitoyltransferase

  5. NM_198044.3 → NP_932161.1  palmitoyltransferase ZDHHC16 isoform 3

    See identical proteins and their annotated locations for NP_932161.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, and lacks an alternate exon and uses an alternate in-frame splice site in the 5' coding region, compared to variant 5. It encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    BC033157, BM678689, DC399731
    Consensus CDS
    CCDS7462.1
    UniProtKB/TrEMBL
    H0Y6E9
    Related
    ENSP00000323360.3, ENST00000353979.7
    Conserved Domains (1) summary
    cl19890
    Location:126 → 175
    DHHC; DHHC palmitoyltransferase

  6. NM_198045.3 → NP_932162.1  palmitoyltransferase ZDHHC16 isoform 4

    See identical proteins and their annotated locations for NP_932162.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons, one in the 5' coding region and the other in the 3' coding region, compared to variant 5. It encodes isoform 4, which is shorter than isoform 1.
    Source sequence(s)
    BC004535, DC399731
    Consensus CDS
    CCDS7463.1
    UniProtKB/Swiss-Prot
    Q969W1
    Related
    ENSP00000304487.8, ENST00000345745.9
    Conserved Domains (1) summary
    pfam01529
    Location:91 → 224
    zf-DHHC; DHHC palmitoyltransferase

  7. NM_198046.3 → NP_932163.1  palmitoyltransferase ZDHHC16 isoform 1

    See identical proteins and their annotated locations for NP_932163.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) represents the longest transcript. Variants 1 and 5 encode the same isoform (1), which is the longest isoform.
    Source sequence(s)
    AJ294945, AK297962, BM678689, DC399731
    Consensus CDS
    CCDS7460.1
    UniProtKB/Swiss-Prot
    D3DR52, D3DR53, D3DR54, Q5JTG7, Q5JTH0, Q8N4Z6, Q8WY84, Q969W1, Q9BSV3
    UniProtKB/TrEMBL
    H0Y6E9
    Related
    ENSP00000377357.1, ENST00000393760.6
    Conserved Domains (1) summary
    pfam01529
    Location:156 → 305
    DHHC; DHHC palmitoyltransferase

RNA

  1. NR_109895.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks three internal exons and uses an alternate splice site in an internal exon, compared to variant 5. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 5z.
    Source sequence(s)
    BC004535, BG769550, DC399731

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    97446175..97457370
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016766.2 → XP_016872255.1  palmitoyltransferase ZDHHC16 isoform X1

    UniProtKB/TrEMBL
    H0Y6E9
    Conserved Domains (1) summary
    pfam01529
    Location:156 → 289
    DHHC; DHHC palmitoyltransferase

  2. XM_047425837.1 → XP_047281793.1  palmitoyltransferase ZDHHC16 isoform X3

  3. XM_017016771.2 → XP_016872260.1  palmitoyltransferase ZDHHC16 isoform X8

    UniProtKB/TrEMBL
    B1AMU0
    Conserved Domains (1) summary
    cl19890
    Location:156 → 185
    DHHC; DHHC palmitoyltransferase

  4. XM_017016768.2 → XP_016872257.1  palmitoyltransferase ZDHHC16 isoform X4

    UniProtKB/TrEMBL
    H0Y6E9
    Conserved Domains (1) summary
    cl19890
    Location:126 → 175
    DHHC; DHHC palmitoyltransferase

  5. XM_047425839.1 → XP_047281795.1  palmitoyltransferase ZDHHC16 isoform X6

  6. XM_047425842.1 → XP_047281798.1  palmitoyltransferase ZDHHC16 isoform X10

  7. XM_006718024.2 → XP_006718087.1  palmitoyltransferase ZDHHC16 isoform X2

    See identical proteins and their annotated locations for XP_006718087.1

    UniProtKB/TrEMBL
    B4DNL2, H0Y6E9
    Related
    ENSP00000396286.1, ENST00000417044.1
    Conserved Domains (1) summary
    pfam01529
    Location:156 → 231
    DHHC; DHHC palmitoyltransferase

  8. XM_017016767.2 → XP_016872256.1  palmitoyltransferase ZDHHC16 isoform X3

    UniProtKB/TrEMBL
    H0Y6E9
    Related
    ENSP00000405240.1, ENST00000420089.5
    Conserved Domains (1) summary
    pfam01529
    Location:156 → 242
    DHHC; DHHC palmitoyltransferase

  9. XM_047425838.1 → XP_047281794.1  palmitoyltransferase ZDHHC16 isoform X6

  10. XM_017016769.2 → XP_016872258.1  palmitoyltransferase ZDHHC16 isoform X5

    UniProtKB/TrEMBL
    H0Y6E9
    Conserved Domains (1) summary
    cl19890
    Location:156 → 250
    DHHC; DHHC palmitoyltransferase

  11. XM_024448233.2 → XP_024304001.1  palmitoyltransferase ZDHHC16 isoform X7

    Conserved Domains (1) summary
    pfam01529
    Location:91 → 240
    zf-DHHC; DHHC palmitoyltransferase

  12. XM_047425841.1 → XP_047281797.1  palmitoyltransferase ZDHHC16 isoform X10

  13. XM_047425840.1 → XP_047281796.1  palmitoyltransferase ZDHHC16 isoform X9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    98326355..98337553
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366914.1 → XP_054222889.1  palmitoyltransferase ZDHHC16 isoform X1

  2. XM_054366917.1 → XP_054222892.1  palmitoyltransferase ZDHHC16 isoform X3

  3. XM_054366923.1 → XP_054222898.1  palmitoyltransferase ZDHHC16 isoform X8

    UniProtKB/TrEMBL
    B1AMU0

  4. XM_054366918.1 → XP_054222893.1  palmitoyltransferase ZDHHC16 isoform X4

  5. XM_054366921.1 → XP_054222896.1  palmitoyltransferase ZDHHC16 isoform X6

  6. XM_054366926.1 → XP_054222901.1  palmitoyltransferase ZDHHC16 isoform X10

  7. XM_054366915.1 → XP_054222890.1  palmitoyltransferase ZDHHC16 isoform X2

    UniProtKB/TrEMBL
    B4DNL2

  8. XM_054366916.1 → XP_054222891.1  palmitoyltransferase ZDHHC16 isoform X3

  9. XM_054366920.1 → XP_054222895.1  palmitoyltransferase ZDHHC16 isoform X6

  10. XM_054366919.1 → XP_054222894.1  palmitoyltransferase ZDHHC16 isoform X5

  11. XM_054366922.1 → XP_054222897.1  palmitoyltransferase ZDHHC16 isoform X7

  12. XM_054366925.1 → XP_054222900.1  palmitoyltransferase ZDHHC16 isoform X10

  13. XM_054366924.1 → XP_054222899.1  palmitoyltransferase ZDHHC16 isoform X9

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q969W1.1 GenPept UniProtKB/Swiss-Prot:Q969W1

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