ILA ILITYHIA [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ILA
Official Full Name: ILITYHIA
Primary source: TAIR:AT1G64790
Locus tag: AT1G64790
See related: Araport:AT1G64790
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F13O11.35; F13O11_35; ILITHYIA
Summary: ILITHYIA (ILA) is a HEAT repeat protein involved in plant immunity. The gene is also involved in systemic acquired resistance induced by P. syringae expressing avrRps4. Loss-of-function mutants of ILA caused pleiotropic defects in the mutant plants. The mutant plants are smaller in size and the leaves are serrated and yellow to light green in color. Required for bacterium-triggered stomatal closure.
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Genomic context

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See ILA in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 62

Sequence:: Chromosome: 1; NC_003070.9 (24064822..24083428, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NOXY7/GCN1 but not GCN2 regulates adaptation to mitochondrial dysfunction, high boron concentration, and activation of plant immunity to infection by Pseudomonas syringae pv tomato.[NOXY7]
Title: Arabidopsis nonresponding to oxylipins locus NOXY7 encodes a yeast GCN1 homolog that mediates noncanonical translation regulation and stress adaptation.
Although both ILA and GCN2 genes are necessary to mediate eIF2alpha phosphorylation upon treatments with the aromatic amino acid biosynthesis inhibitor glyphosate, their mutants develop distinct root and chloroplast phenotypes.
Title: Arabidopsis ILITHYIA protein is necessary for proper chloroplast biogenesis and root development independent of eIF2α phosphorylation.
ILITYHIA(ILA) functions in immunity against bacterial infection. [ILA]
Title: The HEAT repeat protein ILITYHIA is required for plant immunity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001198384.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in induced systemic resistance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within systemic acquired resistance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: ILITYHIA

NP_001185313.1

ILITHYIA (ILA); FUNCTIONS IN: binding; INVOLVED IN: systemic acquired resistance, defense response to bacterium; LOCATED IN: cytosol, nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: HEAT (InterPro:IPR000357), Armadillo-like helical (InterPro:IPR011989), HEAT, type 2 (InterPro:IPR021133), Armadillo-type fold (InterPro:IPR016024).

NP_176659.6

ILITHYIA (ILA); FUNCTIONS IN: binding; INVOLVED IN: systemic acquired resistance, defense response to bacterium; LOCATED IN: cytosol, nucleus, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: HEAT (InterPro:IPR000357), Armadillo-like helical (InterPro:IPR011989), HEAT, type 2 (InterPro:IPR021133), Armadillo-type fold (InterPro:IPR016024); Has 3576 Blast hits to 2493 proteins in 284 species: Archae - 50; Bacteria - 199; Metazoa - 1336; Fungi - 986; Plants - 555; Viruses - 13; Other Eukaryotes - 437 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

24064822..24083428 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_105153.8 → NP_176659.6 ILITYHIA [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_176659.6

Status: REVIEWED

UniProtKB/TrEMBL

A0A178W5M3, A0A654EWQ2

Conserved Domains (6) summary

COG5181
Location:1861 → 2526

HSH155; U2 snRNP spliceosome subunit [RNA processing and modification]

cd00020
Location:2453 → 2562

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam12074
Location:344 → 689

DUF3554; Domain of unknown function (DUF3554)

pfam13513
Location:2268 → 2322

HEAT_EZ; HEAT-like repeat

pfam13646
Location:1442 → 1538

HEAT_2; HEAT repeats

sd00044
Location:1865 → 1893

HEAT; HEAT repeat [structural motif]
NM_001334178.1 → NP_001322207.1 ILITYHIA [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178W5M3, A0A1P8AT97, A0A654EWQ2
NM_001198384.1 → NP_001185313.1 ILITYHIA [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001185313.1

Status: REVIEWED

UniProtKB/Swiss-Prot

F4I893, F4I894, Q9XIR5

UniProtKB/TrEMBL

A0A178W5M3, A0A654EWQ2

Conserved Domains (5) summary

COG5181
Location:1947 → 2612

HSH155; U2 snRNP spliceosome subunit [RNA processing and modification]

cd00020
Location:2539 → 2648

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam12074
Location:463 → 808

DUF3554; Domain of unknown function (DUF3554)

pfam13513
Location:2354 → 2408

HEAT_EZ; HEAT-like repeat

sd00044
Location:1951 → 1979

HEAT; HEAT repeat [structural motif]