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METTL25 methyltransferase like 25 [ Homo sapiens (human) ]

Gene ID: 84190, updated on 5-Mar-2024

Summary

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Official Symbol
METTL25provided by HGNC
Official Full Name
methyltransferase like 25provided by HGNC
Primary source
HGNC:HGNC:26228
See related
Ensembl:ENSG00000127720 AllianceGenome:HGNC:26228
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C12orf26
Summary
Predicted to enable methyltransferase activity. Predicted to be involved in methylation. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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Location:
12q21.31
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (82358529..82479239)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (82337989..82458720)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (82752308..82873018)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2426 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:82495963-82497162 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:82514940-82515440 Neighboring gene uncharacterized LOC105369873 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:82540979-82541568 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:82707907-82708408 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:82751975-82752535 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:82752536-82753096 Neighboring gene Sharpr-MPRA regulatory region 15106 Neighboring gene coiled-coil domain containing 59 Neighboring gene hepatitis A virus cellular receptor 1 pseudogene Neighboring gene uncharacterized LOC107987180 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:82926586-82926790 Neighboring gene KIAA1586 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Creation of genome-wide protein expression libraries using random activation of gene expression. Harrington JJ, et al. Nat Biotechnol, 2001 May. PMID 11329013
  2. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Boldt K, et al. Nat Commun, 2016 May 13. PMID 27173435, Free PMC Article
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. Oláh J, et al. J Biol Chem, 2011 Sep 30. PMID 21832049, Free PMC Article
  4. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. Capalbo L, et al. Nat Commun, 2019 Oct 4. PMID 31586073, Free PMC Article
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ22789

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable methyltransferase-like protein 25
Names
methyltransferase-like protein 25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053173.2 RefSeqGene

    Range
    5124..125834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001319675.2 → NP_001306604.1  probable methyltransferase-like protein 25 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' region and initiates translation at downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC083811, AC089998
    UniProtKB/Swiss-Prot
    Q8N6Q8
    Conserved Domains (1) summary
    cl17173
    Location:67 → 333
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. NM_001347934.2 → NP_001334863.1  probable methyltransferase-like protein 25 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC083811, AC089998
    UniProtKB/Swiss-Prot
    Q8N6Q8

  3. NM_032230.3 → NP_115606.2  probable methyltransferase-like protein 25 isoform 1

    See identical proteins and their annotated locations for NP_115606.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC083811, AC089998
    Consensus CDS
    CCDS9024.1
    UniProtKB/Swiss-Prot
    Q8N6Q8, Q9H5Y3
    Related
    ENSP00000248306.3, ENST00000248306.8
    Conserved Domains (1) summary
    cl17173
    Location:154 → 420
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RNA

  1. NR_144940.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC083811, AC089998

  2. NR_144941.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC083811, AC089998

  3. NR_144942.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC083811, AC089998

  4. NR_144943.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC083811, AC089998

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    82358529..82479239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538827.4 → XP_011537129.1  probable methyltransferase-like protein 25 isoform X2

    Conserved Domains (1) summary
    cl17173
    Location:99 → 365
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. XM_011538828.4 → XP_011537130.1  probable methyltransferase-like protein 25 isoform X3

    Conserved Domains (1) summary
    cl17173
    Location:154 → 420
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  3. XM_047429659.1 → XP_047285615.1  probable methyltransferase-like protein 25 isoform X5

  4. XM_011538829.4 → XP_011537131.1  probable methyltransferase-like protein 25 isoform X4

    Related
    ENST00000547357.5
    Conserved Domains (1) summary
    cl17173
    Location:154 → 420
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  5. XM_047429660.1 → XP_047285616.1  probable methyltransferase-like protein 25 isoform X7

  6. XM_047429661.1 → XP_047285617.1  probable methyltransferase-like protein 25 isoform X8

  7. XM_005269186.6 → XP_005269243.2  probable methyltransferase-like protein 25 isoform X6

    Conserved Domains (1) summary
    cl17173
    Location:154 → 420
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  8. XM_047429658.1 → XP_047285614.1  probable methyltransferase-like protein 25 isoform X1

RNA

  1. XR_007063135.1 RNA Sequence

  2. XR_007063138.1 RNA Sequence

  3. XR_944768.4 RNA Sequence

  4. XR_007063137.1 RNA Sequence

  5. XR_007063136.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    82337989..82458720
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373450.1 → XP_054229425.1  probable methyltransferase-like protein 25 isoform X2

  2. XM_054373451.1 → XP_054229426.1  probable methyltransferase-like protein 25 isoform X3

  3. XM_054373453.1 → XP_054229428.1  probable methyltransferase-like protein 25 isoform X5

  4. XM_054373452.1 → XP_054229427.1  probable methyltransferase-like protein 25 isoform X4

  5. XM_054373455.1 → XP_054229430.1  probable methyltransferase-like protein 25 isoform X7

  6. XM_054373456.1 → XP_054229431.1  probable methyltransferase-like protein 25 isoform X8

  7. XM_054373454.1 → XP_054229429.1  probable methyltransferase-like protein 25 isoform X6

  8. XM_054373449.1 → XP_054229424.1  probable methyltransferase-like protein 25 isoform X1

RNA

  1. XR_008488698.1 RNA Sequence

  2. XR_008488701.1 RNA Sequence

  3. XR_008488697.1 RNA Sequence

  4. XR_008488700.1 RNA Sequence

  5. XR_008488699.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N6Q8.2 GenPept UniProtKB/Swiss-Prot:Q8N6Q8

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