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HEI10 RING/U-box superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 841784, updated on 18-Sep-2024

Summary

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Official Symbol
HEI10
Official Full Name
RING/U-box superfamily protein
Primary source
TAIR:AT1G53490
Locus tag
AT1G53490
See related
Araport:AT1G53490
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F22G10.16; homolog of human HEI10 ( Enhancer of cell Invasion No.10)
Summary
Encodes HEI10, a RING finger-containing protein. HEI10 belongs to a group of proteins well conserved among species known as ZMM. Required for class I crossover formation.
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Genomic context

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See HEI10 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
10
Sequence:
Chromosome: 1; NC_003070.9 (19963267..19966952)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene craniofacial development protein Neighboring gene mechanosensitive channel of small conductance-like 4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene mto 1 responding down 1 Neighboring gene ncRNA Neighboring gene NAD-dependent epimerase/dehydratase family protein Neighboring gene mitogen-activated protein kinase 18

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Diffusion-mediated HEI10 coarsening can explain meiotic crossover positioning in Arabidopsis. Morgan C, et al. Nat Commun, 2021 Aug 3. PMID 34344879, Free PMC Article
  2. HEI10 is subject to phase separation and mediates RPA1a degradation during meiotic interference-sensitive crossover formation. Wang T, et al. Proc Natl Acad Sci U S A, 2023 Dec 26. PMID 38134200, Free PMC Article
  3. The Arabidopsis HEI10 is a new ZMM protein related to Zip3. Chelysheva L, et al. PLoS Genet, 2012. PMID 22844245, Free PMC Article
  4. The role of rice HEI10 in the formation of meiotic crossovers. Wang K, et al. PLoS Genet, 2012 Jul. PMID 22792078, Free PMC Article
  5. FANCM-associated proteins MHF1 and MHF2, but not the other Fanconi anemia factors, limit meiotic crossovers. Girard C, et al. Nucleic Acids Res, 2014 Aug. PMID 25038251, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HEI10 is subject to phase separation and mediates RPA1a degradation during meiotic interference-sensitive crossover formation.
    Title: HEI10 is subject to phase separation and mediates RPA1a degradation during meiotic interference-sensitive crossover formation.
  2. Diffusion-mediated HEI10 coarsening can explain meiotic crossover positioning in Arabidopsis.
    Title: Diffusion-mediated HEI10 coarsening can explain meiotic crossover positioning in Arabidopsis.
  3. HEI10 protein is present as numerous foci on chromosome axes during early meiotic prophase and is retained until the end of prophase at a limited number of sites corresponding to crossovers. HEI10 is structurally and functionally related to the yeast Zip3 ZMM and that it is absolutely required for class I crossover formation in Arabidopsis thaliana. [HEI10]
    Title: The Arabidopsis HEI10 is a new ZMM protein related to Zip3.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001333596.1
NM_104227.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chiasma assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chiasma ISS
Inferred from Sequence or Structural Similarity
more info
  
colocalizes_with chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
RING/U-box superfamily protein
NP_175754.2
  • RING/U-box superfamily protein; Has 175 Blast hits to 173 proteins in 83 species: Archae - 2; Bacteria - 14; Metazoa - 69; Fungi - 24; Plants - 38; Viruses - 0; Other Eukaryotes - 28 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    19963267..19966952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_104227.2 → NP_175754.2  RING/U-box superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_175754.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4HRI2, Q9C8L1, Q9LPG5
    UniProtKB/TrEMBL
    A0A178W8Z0
    Conserved Domains (2) summary
    pfam10158
    Location:106 → 173
    LOH1CR12; Tumour suppressor protein
    pfam14634
    Location:2 → 43
    zf-RING_5; zinc-RING finger domain

  2. NM_001333596.1 → NP_001321879.1  RING/U-box superfamily protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178W7F3, A0A1P8AS84
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F4HRI2.1

Gene LinkOut

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