mMDH1 Lactate/malate dehydrogenase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: mMDH1
Official Full Name: Lactate/malate dehydrogenase family protein
Primary source: TAIR:AT1G53240
Locus tag: AT1G53240
See related: Araport:AT1G53240
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: mitochondrial malate dehydrogenase 1
Summary: mMDH1 encodes a mitochrondrial malate dehydrogenase. It is expressed at higher levels than the other mitochrondrial isoform mMDH2 (At3G15020) according to transcript and proteomic analyses.
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Genomic context

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See mMDH1 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 7

Sequence:: Chromosome: 1; NC_003070.9 (19854615..19857146, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study has shown that mMDH is an important respiratory element in Arabidopsis seeds, with a significant impact on early seedling growth. Perturbation of both mMDH genes in Arabidopsis seeds significantly elevated respiration rates at all stages of seed maturation, markedly reduced reserve accumulation, and accelerated the aging process in seeds.
Title: Loss of Mitochondrial Malate Dehydrogenase Activity Alters Seed Metabolism Impairing Seed Maturation and Post-Germination Growth in Arabidopsis.
Results suggest that mitochondrial malate dehydrogenase (mMDH) activity is finely controlled in response to variations in mitochondrial adenine nucleotide balance.
Title: Adenine nucleotide-dependent and redox-independent control of mitochondrial malate dehydrogenase activity in Arabidopsis thaliana.
a metabolic repair cycle involving mMDH and l-2HGDH is conserved in plant and mammalian mitochondria. [Malate dehydrogenase] [mMDH1]
Title: Plants Possess a Cyclic Mitochondrial Metabolic Pathway similar to the Mammalian Metabolic Repair Mechanism Involving Malate Dehydrogenase and l-2-Hydroxyglutarate Dehydrogenase.
Mitochondrial malate dehydrogenase 1 exhibited a negative correlation of mRNA and protein levels during cold-acclimation and de-acclimation in Arabidopsis.
Title: Analysis of differential expression patterns of mRNA and protein during cold-acclimation and de-acclimation in Arabidopsis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_104202.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables L-malate dehydrogenase (NAD+) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables copper ion binding	HDA more info	PubMed

Process	Evidence Code	Pubs
involved_in malate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to cold	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
NOT located_in Golgi apparatus	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in plant-type cell wall	HDA more info	PubMed

General protein information

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Preferred Names: Lactate/malate dehydrogenase family protein

NP_564625.1

Lactate/malate dehydrogenase family protein; FUNCTIONS IN: malate dehydrogenase activity, copper ion binding; INVOLVED IN: response to cadmium ion, response to salt stress, response to cold, defense response to bacterium, peptidyl-cysteine S-nitrosylation; LOCATED IN: mitochondrion, cell wall, chloroplast; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Lactate/malate dehydrogenase, C-terminal (InterPro:IPR022383), Malate dehydrogenase, NAD-dependent, eukaryote/gamma proteobacteria (InterPro:IPR010097), NAD(P)-binding domain (InterPro:IPR016040), L-lactate/malate dehydrogenase (InterPro:IPR001557), Lactate/malate dehydrogenase, N-terminal (InterPro:IPR001236), Malate dehydrogenase, active site (InterPro:IPR001252), Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal (InterPro:IPR015955); BEST Arabidopsis thaliana protein match is: Lactate/malate dehydrogenase family protein (TAIR:AT3G15020.1); Has 17502 Blast hits to 17499 proteins in 5422 species: Archae - 240; Bacteria - 12205; Metazoa - 1281; Fungi - 536; Plants - 649; Viruses - 0; Other Eukaryotes - 2591 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

19854615..19857146 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_104202.3 → NP_564625.1 Lactate/malate dehydrogenase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_564625.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8LBB9, Q9MAH7, Q9ZP06

UniProtKB/TrEMBL

A0A178WFE8, A0A654EJR6

Conserved Domains (2) summary

cd01337
Location:31 → 339

MDH_glyoxysomal_mitochondrial; Glyoxysomal and mitochondrial malate dehydrogenases

PLN00106
Location:12 → 334

PLN00106; malate dehydrogenase