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NLRC5 NLR family CARD domain containing 5 [ Homo sapiens (human) ]

Gene ID: 84166, updated on 3-Apr-2024

Summary

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Official Symbol
NLRC5provided by HGNC
Official Full Name
NLR family CARD domain containing 5provided by HGNC
Primary source
HGNC:HGNC:29933
See related
Ensembl:ENSG00000140853 MIM:613537; AllianceGenome:HGNC:29933
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NOD4; NOD27; CLR16.1
Summary
This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways. [provided by RefSeq, Oct 2011]
Expression
Broad expression in spleen (RPKM 23.6), lymph node (RPKM 20.1) and 22 other tissues See more
Orthologs
mouse all
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Genomic context

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See NLRC5 in Genome Data Viewer
Location:
16q13
Exon count:
55
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (56989557..57083520)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (62785869..62879790)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (57023469..57117432)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:56995483-56996470 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:56996471-56997458 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10866 Neighboring gene Sharpr-MPRA regulatory region 2679 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10867 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57016890-57017390 Neighboring gene uncharacterized LOC124903696 Neighboring gene cholesteryl ester transfer protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57023277-57023776 Neighboring gene Sharpr-MPRA regulatory region 12884 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10869 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:57033747-57034248 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10870 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10871 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10872 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10873 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10874 Neighboring gene CFAP69 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57060363-57060881 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_43539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10875 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10876 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10879 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10878 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10880 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:57095254-57096453 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57103335-57104060 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57104061-57104785 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10881 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7519 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7520 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7521 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7522 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57137039-57137994 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57139274-57139873 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10882 Neighboring gene copine 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7523 Neighboring gene Sharpr-MPRA regulatory region 3054 Neighboring gene Sharpr-MPRA regulatory region 6435 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57183845-57184634 Neighboring gene proteasome activator subunit 3 interacting protein 1 Neighboring gene NANOG hESC enhancer GRCh37_chr16:57212532-57213113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10884

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. NLRC5 germline variants as potential pharmacogenomic markers for immune checkpoint inhibitors. Meng XY. J Immunother Cancer, 2023 Jun. PMID 37277194, Free PMC Article
  2. Transcription and splicing regulation by NLRC5 shape the interferon response in human pancreatic β cells. Szymczak F, et al. Sci Adv, 2022 Sep 16. PMID 36103539, Free PMC Article
  3. NLRC5 Might Promote Endometrial Cancer Progression by Inducing PD-L1 Expression. Zhu SD, et al. Technol Cancer Res Treat, 2022 Jan-Dec. PMID 35880269, Free PMC Article
  4. NLRC5 modulates phenotypic transition and inflammation of human venous smooth muscle cells by activating Wnt/β-catenin pathway via TLR4 in varicose veins. Fang T, et al. Microvasc Res, 2022 Sep. PMID 35835172
  5. Selective autophagy of NLRC5 promotes immune evasion of endometrial cancer. Zhan L, et al. Autophagy, 2022 Apr. PMID 35174769, Free PMC Article

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rescue of NLRC5 expression restores antigen processing machinery in head and neck cancer cells lacking functional STAT1 and p53.
    Title: Rescue of NLRC5 expression restores antigen processing machinery in head and neck cancer cells lacking functional STAT1 and p53.
  2. NLRC5 overexpression in ovarian tumors remodels the tumor microenvironment and increases T-cell reactivity toward autologous tumor-associated antigens.
    Title: NLRC5 overexpression in ovarian tumors remodels the tumor microenvironment and increases T-cell reactivity toward autologous tumor-associated antigens.
  3. USP14-mediated NLRC5 upregulation inhibits endothelial cell activation and inflammation in atherosclerosis.
    Title: USP14-mediated NLRC5 upregulation inhibits endothelial cell activation and inflammation in atherosclerosis.
  4. NLRC5 germline variants as potential pharmacogenomic markers for immune checkpoint inhibitors.
    Title: NLRC5 germline variants as potential pharmacogenomic markers for immune checkpoint inhibitors.
  5. NLRC5-CIITA Fusion Protein as an Effective Inducer of MHC-I Expression and Antitumor Immunity.
    Title: NLRC5-CIITA Fusion Protein as an Effective Inducer of MHC-I Expression and Antitumor Immunity.
  6. NLRC5 restricts dengue virus infection by promoting the autophagic degradation of viral NS3 through E3 ligase CUL2 (cullin 2).
    Title: NLRC5 restricts dengue virus infection by promoting the autophagic degradation of viral NS3 through E3 ligase CUL2 (cullin 2).
  7. NLR family CARD domain containing 5 promotes hypoxia-induced cancer progress and carboplatin resistance by activating PI3K/AKT via carcinoembryonic antigen related cell adhesion molecule 1 in non-small cell lung cancer.
    Title: NLR family CARD domain containing 5 promotes hypoxia-induced cancer progress and carboplatin resistance by activating PI3K/AKT via carcinoembryonic antigen related cell adhesion molecule 1 in non-small cell lung cancer.
  8. BMI1 induces ubiquitination and protein degradation of Nod-like receptor family CARD domain containing 5 and suppresses human leukocyte antigen class I expression to induce immune escape in non-small cell lung cancer.
    Title: BMI1 induces ubiquitination and protein degradation of Nod-like receptor family CARD domain containing 5 and suppresses human leukocyte antigen class I expression to induce immune escape in non-small cell lung cancer.
  9. Transcription and splicing regulation by NLRC5 shape the interferon response in human pancreatic beta cells.
    Title: Transcription and splicing regulation by NLRC5 shape the interferon response in human pancreatic β cells.
  10. NLRC5 modulates phenotypic transition and inflammation of human venous smooth muscle cells by activating Wnt/beta-catenin pathway via TLR4 in varicose veins.
    Title: NLRC5 modulates phenotypic transition and inflammation of human venous smooth muscle cells by activating Wnt/β-catenin pathway via TLR4 in varicose veins.
Submit: New GeneRIF Correction See all GeneRIFs (68)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
EBI GWAS Catalog
Genome-wide association study of clinical dimensions of schizophrenia: polygenic effect on disorganized symptoms.
EBI GWAS Catalog
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of NLR family, CARD domain containing 5 (NLRC5) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21709, FLJ39711

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to virus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of type I interferon-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of type I interferon-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of MHC class I biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of MHC class I biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of type I interferon-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of type II interferon-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of type II interferon-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to bacterium IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein NLRC5
Names
NOD-like receptor C5
caterpiller protein 16.1
nucleotide-binding oligomerization domain protein 4
nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 5
nucleotide-binding oligomerization domains 27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030337.3 RefSeqGene

    Range
    5073..99036
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001330552.2 → NP_001317481.1  protein NLRC5 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2 and 4 both encode the same isoform (2).
    Source sequence(s)
    AA722775, AC009090, AC023825
    Consensus CDS
    CCDS81985.1
    UniProtKB/Swiss-Prot
    Q86WI3
    Related
    ENSP00000441727.1, ENST00000539144.5
    Conserved Domains (6) summary
    sd00033
    Location:1495 → 1516
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:1436 → 1466
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:222 → 383
    NACHT; NACHT domain
    pfam17776
    Location:514 → 628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:1 → 95
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:1493 → 1793
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  2. NM_001384950.1 → NP_001371879.1  protein NLRC5 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variant 1, encodes isoform 1.
    Source sequence(s)
    AC009090, AC023825
    Consensus CDS
    CCDS10773.1
    UniProtKB/Swiss-Prot
    B5MEF1, C9JMD8, Q6P4A6, Q86VM7, Q86WI3, Q8NF42, Q8TEE2, Q8TEJ1, Q969L7
    Related
    ENSP00000509992.1, ENST00000688547.1
    Conserved Domains (6) summary
    sd00033
    Location:1524 → 1545
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:1465 → 1495
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:222 → 383
    NACHT; NACHT domain
    pfam17776
    Location:514 → 628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:1 → 95
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:1522 → 1822
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  3. NM_001384951.1 → NP_001371880.1  protein NLRC5 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variant 2, encodes isoform 2.
    Source sequence(s)
    AC009090, AC023825
    Consensus CDS
    CCDS81985.1
    Conserved Domains (6) summary
    sd00033
    Location:1495 → 1516
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:1436 → 1466
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:222 → 383
    NACHT; NACHT domain
    pfam17776
    Location:514 → 628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:1 → 95
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:1493 → 1793
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  4. NM_001384952.1 → NP_001371881.1  protein NLRC5 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variant 6, encodes isoform 3.
    Source sequence(s)
    AC009090, AC023825
    Conserved Domains (6) summary
    sd00033
    Location:1523 → 1544
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:1464 → 1494
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:222 → 383
    NACHT; NACHT domain
    pfam17776
    Location:514 → 628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:1 → 95
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:1521 → 1821
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  5. NM_001384953.1 → NP_001371882.1  protein NLRC5 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variant 5, encodes isoform 3.
    Source sequence(s)
    AC009090, AC023825
    Conserved Domains (6) summary
    sd00033
    Location:1523 → 1544
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:1464 → 1494
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:222 → 383
    NACHT; NACHT domain
    pfam17776
    Location:514 → 628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:1 → 95
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:1521 → 1821
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  6. NM_001384954.1 → NP_001371883.1  protein NLRC5 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC009090, AC023825
    Conserved Domains (6) summary
    sd00033
    Location:1496 → 1517
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:1437 → 1467
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:222 → 383
    NACHT; NACHT domain
    pfam17776
    Location:514 → 628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:1 → 95
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:1494 → 1794
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  7. NM_001384955.1 → NP_001371884.1  protein NLRC5 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC009090, AC023825
    Conserved Domains (6) summary
    sd00033
    Location:1495 → 1516
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:1436 → 1466
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:222 → 383
    NACHT; NACHT domain
    pfam17776
    Location:514 → 628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:1 → 95
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:1493 → 1793
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  8. NM_001384956.1 → NP_001371885.1  protein NLRC5 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC009090, AC023825
    Conserved Domains (6) summary
    sd00033
    Location:1495 → 1516
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:1436 → 1466
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:222 → 383
    NACHT; NACHT domain
    pfam17776
    Location:514 → 628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:1 → 95
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:1493 → 1793
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  9. NM_001384957.1 → NP_001371886.1  protein NLRC5 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC009090, AC023825
    Conserved Domains (6) summary
    sd00033
    Location:1494 → 1515
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:1435 → 1465
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:222 → 383
    NACHT; NACHT domain
    pfam17776
    Location:514 → 628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:1 → 95
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:1492 → 1792
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  10. NM_001384958.1 → NP_001371887.1  protein NLRC5 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC009090, AC023825
    Conserved Domains (7) summary
    sd00033
    Location:1466 → 1487
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:1407 → 1437
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:222 → 383
    NACHT; NACHT domain
    pfam17776
    Location:514 → 628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:1 → 95
    Atypical_Card; Atypical caspase recruitment domain
    cd21340
    Location:705 → 783
    PPP1R42; protein phosphatase 1 regulatory subunit 42
    cl39015
    Location:1464 → 1764
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  11. NM_001384959.1 → NP_001371888.1  protein NLRC5 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC009090, AC023825
    Conserved Domains (7) summary
    sd00033
    Location:1465 → 1486
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:1406 → 1436
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:222 → 383
    NACHT; NACHT domain
    pfam17776
    Location:514 → 628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:1 → 95
    Atypical_Card; Atypical caspase recruitment domain
    cd21340
    Location:705 → 783
    PPP1R42; protein phosphatase 1 regulatory subunit 42
    cl39015
    Location:1463 → 1763
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  12. NM_001384960.1 → NP_001371889.1  protein NLRC5 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC009090, AC023825
    Conserved Domains (6) summary
    sd00033
    Location:1493 → 1520
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:1383 → 1405
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:222 → 383
    NACHT; NACHT domain
    pfam17776
    Location:514 → 628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:1 → 95
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:1447 → 1735
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  13. NM_001384961.1 → NP_001371890.1  protein NLRC5 isoform 11

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variant 15, encodes isoform 11.
    Source sequence(s)
    AC023825
    UniProtKB/TrEMBL
    H0YGE2
    Conserved Domains (5) summary
    sd00033
    Location:716 → 743
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:222 → 383
    NACHT; NACHT domain
    pfam17776
    Location:514 → 628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:1 → 95
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:690 → 1069
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  14. NM_001384962.1 → NP_001371891.1  protein NLRC5 isoform 11

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variant 14, encodes isoform 11.
    Source sequence(s)
    AC023825
    UniProtKB/TrEMBL
    H0YGE2
    Conserved Domains (5) summary
    sd00033
    Location:716 → 743
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:222 → 383
    NACHT; NACHT domain
    pfam17776
    Location:514 → 628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:1 → 95
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:690 → 1069
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  15. NM_001384963.1 → NP_001371892.1  protein NLRC5 isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variant 17, encodes isoform 12.
    Source sequence(s)
    AC023825
    UniProtKB/TrEMBL
    H0YGE2
    Conserved Domains (5) summary
    sd00033
    Location:716 → 743
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:222 → 383
    NACHT; NACHT domain
    pfam17776
    Location:514 → 628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:1 → 95
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:690 → 1069
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  16. NM_001384964.1 → NP_001371893.1  protein NLRC5 isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variant 16, encodes isoform 12.
    Source sequence(s)
    AC023825
    UniProtKB/TrEMBL
    H0YGE2
    Conserved Domains (5) summary
    sd00033
    Location:716 → 743
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:222 → 383
    NACHT; NACHT domain
    pfam17776
    Location:514 → 628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:1 → 95
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:690 → 1069
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  17. NM_001384965.1 → NP_001371894.1  protein NLRC5 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC023825
    UniProtKB/TrEMBL
    H0YGE2
    Conserved Domains (5) summary
    sd00033
    Location:688 → 715
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:222 → 383
    NACHT; NACHT domain
    pfam17776
    Location:514 → 628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:1 → 95
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:819 → 1040
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  18. NM_001384966.1 → NP_001371895.1  protein NLRC5 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC023825
    UniProtKB/TrEMBL
    H0YGE2
    Conserved Domains (5) summary
    sd00033
    Location:716 → 743
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:222 → 383
    NACHT; NACHT domain
    pfam17776
    Location:514 → 628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:1 → 95
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:690 → 1069
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  19. NM_001384967.1 → NP_001371896.1  protein NLRC5 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC023825
    UniProtKB/TrEMBL
    H0YGE2
    Conserved Domains (5) summary
    sd00033
    Location:716 → 743
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:222 → 383
    NACHT; NACHT domain
    pfam17776
    Location:514 → 628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:1 → 95
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:690 → 1069
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  20. NM_001384968.1 → NP_001371897.1  protein NLRC5 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC023825
    UniProtKB/TrEMBL
    H0YGE2
    Conserved Domains (5) summary
    sd00033
    Location:716 → 743
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:222 → 383
    NACHT; NACHT domain
    pfam17776
    Location:514 → 628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:1 → 95
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:690 → 1069
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  21. NM_001384969.1 → NP_001371898.1  protein NLRC5 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC023825
    UniProtKB/TrEMBL
    H0YGE2
    Conserved Domains (5) summary
    sd00033
    Location:716 → 743
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:222 → 383
    NACHT; NACHT domain
    pfam17776
    Location:514 → 628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:1 → 95
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:690 → 1069
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  22. NM_001384970.1 → NP_001371899.1  protein NLRC5 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC023825
    UniProtKB/TrEMBL
    H0YGE2
    Conserved Domains (5) summary
    sd00033
    Location:716 → 743
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:222 → 383
    NACHT; NACHT domain
    pfam17776
    Location:514 → 628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:1 → 95
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:690 → 1069
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  23. NM_001384971.1 → NP_001371900.1  protein NLRC5 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC023825
    UniProtKB/TrEMBL
    H0YGE2
    Conserved Domains (5) summary
    sd00033
    Location:716 → 743
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:222 → 383
    NACHT; NACHT domain
    pfam17776
    Location:514 → 628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:1 → 95
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:690 → 1069
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  24. NM_001384972.1 → NP_001371901.1  protein NLRC5 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC023825
    UniProtKB/TrEMBL
    H0YGE2
    Conserved Domains (5) summary
    sd00033
    Location:659 → 686
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:205 → 326
    NACHT; NACHT domain
    pfam17776
    Location:457 → 571
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:1 → 95
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:633 → 989
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  25. NM_001384973.1 → NP_001371902.1  protein NLRC5 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC023825
    Conserved Domains (6) summary
    sd00033
    Location:716 → 743
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:222 → 383
    NACHT; NACHT domain
    pfam17776
    Location:514 → 628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:1 → 95
    Atypical_Card; Atypical caspase recruitment domain
    cd21340
    Location:705 → 783
    PPP1R42; protein phosphatase 1 regulatory subunit 42
    cl39015
    Location:745 → 1069
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  26. NM_032206.5 → NP_115582.4  protein NLRC5 isoform 1

    See identical proteins and their annotated locations for NP_115582.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 3 both encode the same isoform (1).
    Source sequence(s)
    AC009090, AC023825
    Consensus CDS
    CCDS10773.1
    UniProtKB/Swiss-Prot
    B5MEF1, C9JMD8, Q6P4A6, Q86VM7, Q86WI3, Q8NF42, Q8TEE2, Q8TEJ1, Q969L7
    Related
    ENSP00000262510.6, ENST00000262510.10
    Conserved Domains (6) summary
    sd00033
    Location:1524 → 1545
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:1465 → 1495
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:222 → 383
    NACHT; NACHT domain
    pfam17776
    Location:514 → 628
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:1 → 95
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:1522 → 1822
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RNA

  1. NR_169512.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC009090, AC023825

  2. NR_169513.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC009090, AC023825

  3. NR_169514.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC023825

  4. NR_169515.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC009090, AC023825

  5. NR_169516.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC009090, AC023825

  6. NR_169517.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC009090, AC023825
    Related
    ENST00000545081.5

  7. NR_169518.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC009090, AC023825

  8. NR_169519.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC009090, AC023825

  9. NR_169520.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC009090, AC023825

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    56989557..57083520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434762.1 → XP_047290718.1  protein NLRC5 isoform X3

  2. XM_047434763.1 → XP_047290719.1  protein NLRC5 isoform X4

  3. XM_047434760.1 → XP_047290716.1  protein NLRC5 isoform X1

  4. XM_047434761.1 → XP_047290717.1  protein NLRC5 isoform X2

  5. XM_047434764.1 → XP_047290720.1  protein NLRC5 isoform X5

  6. XM_006721300.3 → XP_006721363.1  protein NLRC5 isoform X7

    UniProtKB/TrEMBL
    H0YGE2
    Conserved Domains (5) summary
    smart00382
    Location:221 → 365
    AAA; ATPases associated with a variety of cellular activities
    COG4886
    Location:731 → 936
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00116
    Location:690 → 1069
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:716 → 743
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:222 → 383
    NACHT; NACHT domain

  7. XM_047434765.1 → XP_047290721.1  protein NLRC5 isoform X7

  8. XM_017023770.2 → XP_016879259.1  protein NLRC5 isoform X6

    UniProtKB/TrEMBL
    H0YGE2
    Related
    ENSP00000442906.1, ENST00000538805.5

  9. XM_047434766.1 → XP_047290722.1  protein NLRC5 isoform X8

RNA

  1. XR_001752000.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    62785869..62879790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314144.1 → XP_054170119.1  protein NLRC5 isoform X3

  2. XM_054314145.1 → XP_054170120.1  protein NLRC5 isoform X4

  3. XM_054314142.1 → XP_054170117.1  protein NLRC5 isoform X1

  4. XM_054314143.1 → XP_054170118.1  protein NLRC5 isoform X2

  5. XM_054314146.1 → XP_054170121.1  protein NLRC5 isoform X5

  6. XM_054314148.1 → XP_054170123.1  protein NLRC5 isoform X7

  7. XM_054314149.1 → XP_054170124.1  protein NLRC5 isoform X7

  8. XM_054314147.1 → XP_054170122.1  protein NLRC5 isoform X6

  9. XM_054314150.1 → XP_054170125.1  protein NLRC5 isoform X8

RNA

  1. XR_008484741.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86WI3.3 GenPept UniProtKB/Swiss-Prot:Q86WI3

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