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SLC41A2 solute carrier family 41 member 2 [ Homo sapiens (human) ]

Gene ID: 84102, updated on 5-Mar-2024

Summary

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Official Symbol
SLC41A2provided by HGNC
Official Full Name
solute carrier family 41 member 2provided by HGNC
Primary source
HGNC:HGNC:31045
See related
Ensembl:ENSG00000136052 MIM:610802; AllianceGenome:HGNC:31045
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLC41A1-L1
Summary
Predicted to enable inorganic cation transmembrane transporter activity. Predicted to be involved in magnesium ion transmembrane transport. Predicted to act upstream of or within metal ion transport. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver (RPKM 11.3), duodenum (RPKM 5.8) and 20 other tissues See more
Orthologs
mouse all
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Genomic context

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See SLC41A2 in Genome Data Viewer
Location:
12q23.3
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (104801801..104958746, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (104763412..104920359, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (105195579..105352524, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene carbohydrate sulfotransferase 11 Neighboring gene ATP synthase F(0) complex subunit C1, mitochondrial-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6921 Neighboring gene Sharpr-MPRA regulatory region 14866 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:104920569-104921159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6922 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:104949096-104949598 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:104950760-104951594 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23947 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6923 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6924 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6925 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6926 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6927 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:104997281-104997908 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:104997909-104998535 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:104998957-104999544 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:104999545-105000132 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr12:105017531-105018268 Neighboring gene microRNA 3922 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:105026139-105026640 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6928 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6929 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:105065189-105065793 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:105081721-105081916 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6930 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6931 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:105102028-105102832 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:105102833-105103637 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:105114284-105114912 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:105116877-105117495 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6934 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:105136527-105137148 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:105144840-105145417 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6936 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24027 Neighboring gene Sharpr-MPRA regulatory region 12146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6937 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24038 Neighboring gene Sharpr-MPRA regulatory region 3023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6938 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4799 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4800 Neighboring gene uncharacterized LOC105369952 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:105379748-105380260 Neighboring gene keratin 18 pseudogene 20 Neighboring gene NOP protein chaperone 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. SLC41A2 encodes a plasma-membrane Mg2+ transporter. Sahni J, et al. Biochem J, 2007 Jan 15. PMID 16984228, Free PMC Article
  2. Functional characterization of the mouse [corrected] solute carrier, SLC41A2. Goytain A, et al. Biochem Biophys Res Commun, 2005 May 13. PMID 15809054
  3. The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters. Wabakken T, et al. Biochem Biophys Res Commun, 2003 Jul 4. PMID 12810078
  4. Systematic identification of pathological lamin A interactors. Dittmer TA, et al. Mol Biol Cell, 2014 May. PMID 24623722, Free PMC Article
  5. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. Xiao T, et al. Proc Natl Acad Sci U S A, 2018 Jul 31. PMID 29987050, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC125330, MGC125331, DKFZp434K0427

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables magnesium ion transmembrane transporter activity TAS
Traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cobalt ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in iron ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in magnesium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in magnesium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in manganese ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in nickel cation transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
solute carrier family 41 member 2
Names
SLC41A1-like 1
solute carrier family 41 (magnesium transporter), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001352169.2 → NP_001339098.1  solute carrier family 41 member 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same isoform (a).
    Source sequence(s)
    AC089985, AC090051
    Consensus CDS
    CCDS9100.2
    UniProtKB/Swiss-Prot
    Q3KP68, Q96JW4, Q9H0E5
    Conserved Domains (1) summary
    pfam01769
    Location:414 → 555
    MgtE; Divalent cation transporter

  2. NM_001352170.3 → NP_001339099.1  solute carrier family 41 member 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same isoform (a).
    Source sequence(s)
    AC089985, AC090051
    Consensus CDS
    CCDS9100.2
    UniProtKB/Swiss-Prot
    Q3KP68, Q96JW4, Q9H0E5
    Conserved Domains (1) summary
    pfam01769
    Location:414 → 555
    MgtE; Divalent cation transporter

  3. NM_001352171.3 → NP_001339100.1  solute carrier family 41 member 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same isoform (a).
    Source sequence(s)
    AC089985, AC090051
    Consensus CDS
    CCDS9100.2
    UniProtKB/Swiss-Prot
    Q3KP68, Q96JW4, Q9H0E5
    Related
    ENSP00000258538.3, ENST00000258538.8
    Conserved Domains (1) summary
    pfam01769
    Location:414 → 555
    MgtE; Divalent cation transporter

  4. NM_001352172.3 → NP_001339101.1  solute carrier family 41 member 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same isoform (a).
    Source sequence(s)
    AC089985, AC090051
    Consensus CDS
    CCDS9100.2
    UniProtKB/Swiss-Prot
    Q3KP68, Q96JW4, Q9H0E5
    Conserved Domains (1) summary
    pfam01769
    Location:414 → 555
    MgtE; Divalent cation transporter

  5. NM_001387125.1 → NP_001374054.1  solute carrier family 41 member 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same isoform (a).
    Source sequence(s)
    AC089985, AC090051
    Consensus CDS
    CCDS9100.2
    UniProtKB/Swiss-Prot
    Q3KP68, Q96JW4, Q9H0E5
    Conserved Domains (1) summary
    pfam01769
    Location:414 → 555
    MgtE; Divalent cation transporter

  6. NM_001387126.1 → NP_001374055.1  solute carrier family 41 member 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same isoform (a).
    Source sequence(s)
    AC089985, AC090051
    Consensus CDS
    CCDS9100.2
    UniProtKB/Swiss-Prot
    Q3KP68, Q96JW4, Q9H0E5
    Conserved Domains (1) summary
    pfam01769
    Location:414 → 555
    MgtE; Divalent cation transporter

  7. NM_001387127.1 → NP_001374056.1  solute carrier family 41 member 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same isoform (a).
    Source sequence(s)
    AC089985, AC090051
    Consensus CDS
    CCDS9100.2
    UniProtKB/Swiss-Prot
    Q3KP68, Q96JW4, Q9H0E5
    Conserved Domains (1) summary
    pfam01769
    Location:414 → 555
    MgtE; Divalent cation transporter

  8. NM_001387128.1 → NP_001374057.1  solute carrier family 41 member 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variants 10 and 11, encodes isoform b.
    Source sequence(s)
    AC089985, AC090051
    Conserved Domains (1) summary
    pfam01769
    Location:200 → 332
    MgtE; Divalent cation transporter

  9. NM_001387129.1 → NP_001374058.1  solute carrier family 41 member 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 9 and 11, encodes isoform b.
    Source sequence(s)
    AC089985, AC090051
    Conserved Domains (1) summary
    pfam01769
    Location:200 → 332
    MgtE; Divalent cation transporter

  10. NM_001387130.1 → NP_001374059.1  solute carrier family 41 member 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variants 9 and 10, encodes isoform b.
    Source sequence(s)
    AC089985, AC090051
    Conserved Domains (1) summary
    pfam01769
    Location:200 → 332
    MgtE; Divalent cation transporter

  11. NM_001387131.1 → NP_001374060.1  solute carrier family 41 member 2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variants 13 and 14, encodes isoform c.
    Source sequence(s)
    AC089985, AC090051
    Conserved Domains (1) summary
    pfam01769
    Location:200 → 332
    MgtE; Divalent cation transporter

  12. NM_001387132.1 → NP_001374061.1  solute carrier family 41 member 2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variants 12 and 14, encodes isoform c.
    Source sequence(s)
    AC089985, AC090051
    Conserved Domains (1) summary
    pfam01769
    Location:200 → 332
    MgtE; Divalent cation transporter

  13. NM_001387133.1 → NP_001374062.1  solute carrier family 41 member 2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14), as well as variants 12 and 13, encodes isoform c.
    Source sequence(s)
    AC089985, AC090051
    Conserved Domains (1) summary
    pfam01769
    Location:200 → 332
    MgtE; Divalent cation transporter

  14. NM_032148.6 → NP_115524.3  solute carrier family 41 member 2 isoform a

    See identical proteins and their annotated locations for NP_115524.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1-8 all encode the same isoform (a).
    Source sequence(s)
    AC089985, AC090051
    Consensus CDS
    CCDS9100.2
    UniProtKB/Swiss-Prot
    Q3KP68, Q96JW4, Q9H0E5
    Conserved Domains (1) summary
    pfam01769
    Location:414 → 555
    MgtE; Divalent cation transporter

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    104801801..104958746 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047429648.1 → XP_047285604.1  solute carrier family 41 member 2 isoform X1

    UniProtKB/Swiss-Prot
    Q3KP68, Q96JW4, Q9H0E5

  2. XM_017020013.2 → XP_016875502.1  solute carrier family 41 member 2 isoform X1

    UniProtKB/Swiss-Prot
    Q3KP68, Q96JW4, Q9H0E5
    Conserved Domains (1) summary
    pfam01769
    Location:414 → 555
    MgtE; Divalent cation transporter

  3. XM_005269179.2 → XP_005269236.1  solute carrier family 41 member 2 isoform X1

    See identical proteins and their annotated locations for XP_005269236.1

    UniProtKB/Swiss-Prot
    Q3KP68, Q96JW4, Q9H0E5
    Conserved Domains (1) summary
    pfam01769
    Location:414 → 555
    MgtE; Divalent cation transporter

  4. XM_011538811.3 → XP_011537113.1  solute carrier family 41 member 2 isoform X1

    See identical proteins and their annotated locations for XP_011537113.1

    UniProtKB/Swiss-Prot
    Q3KP68, Q96JW4, Q9H0E5
    Conserved Domains (1) summary
    pfam01769
    Location:414 → 555
    MgtE; Divalent cation transporter

  5. XM_017020016.3 → XP_016875505.1  solute carrier family 41 member 2 isoform X4

  6. XM_011538813.3 → XP_011537115.1  solute carrier family 41 member 2 isoform X5

    Conserved Domains (1) summary
    pfam01769
    Location:188 → 328
    MgtE; Divalent cation transporter

  7. XM_047429649.1 → XP_047285605.1  solute carrier family 41 member 2 isoform X2

  8. XM_047429650.1 → XP_047285606.1  solute carrier family 41 member 2 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    104763412..104920359 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373422.1 → XP_054229397.1  solute carrier family 41 member 2 isoform X1

    UniProtKB/Swiss-Prot
    Q3KP68, Q96JW4, Q9H0E5

  2. XM_054373423.1 → XP_054229398.1  solute carrier family 41 member 2 isoform X1

    UniProtKB/Swiss-Prot
    Q3KP68, Q96JW4, Q9H0E5

  3. XM_054373424.1 → XP_054229399.1  solute carrier family 41 member 2 isoform X1

    UniProtKB/Swiss-Prot
    Q3KP68, Q96JW4, Q9H0E5

  4. XM_054373425.1 → XP_054229400.1  solute carrier family 41 member 2 isoform X1

    UniProtKB/Swiss-Prot
    Q3KP68, Q96JW4, Q9H0E5

  5. XM_054373428.1 → XP_054229403.1  solute carrier family 41 member 2 isoform X4

  6. XM_054373430.1 → XP_054229405.1  solute carrier family 41 member 2 isoform X5

  7. XM_054373429.1 → XP_054229404.1  solute carrier family 41 member 2 isoform X6

  8. XM_054373426.1 → XP_054229401.1  solute carrier family 41 member 2 isoform X2

  9. XM_054373427.1 → XP_054229402.1  solute carrier family 41 member 2 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96JW4.2 GenPept UniProtKB/Swiss-Prot:Q96JW4

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