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FAB1D FORMS APLOID AND BINUCLEATE CELLS 1A [ Arabidopsis thaliana (thale cress) ]

Gene ID: 840326, updated on 15-Oct-2023

Summary

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Gene symbol
FAB1D
Gene description
FORMS APLOID AND BINUCLEATE CELLS 1A
Primary source
Araport:AT1G34260
Locus tag
AT1G34260
See related
TAIR:AT1G34260
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F23M19.8; F23M19_8; FORMS APLOID AND BINUCLEATE CELLS 1A
Summary
Encodes a protein that is predicted to act as a phosphatidylinositol-3P 5-kinase, but, because it lacks a FYVE domain, it is unlikely to be efficiently targeted to membranes containing the porposed phosphatidylinositol-3P substrate. Therefore, its molecular function remains unknown.
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Genomic context

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See FAB1D in Genome Data Viewer
Location:
chromosome: 1
Exon count:
14
Sequence:
Chromosome: 1; NC_003070.9 (12485318..12492207)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Putative membrane lipoprotein Neighboring gene pseudo Neighboring gene Exostosin family protein Neighboring gene miscRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of FAB1 phosphatidylinositol kinases in Arabidopsis pollen tube growth and fertilization. Serrazina S, et al. New Phytol, 2014 Aug. PMID 24807078
  2. Rapid structural changes and acidification of guard cell vacuoles during stomatal closure require phosphatidylinositol 3,5-bisphosphate. Bak G, et al. Plant Cell, 2013 Jun. PMID 23757398, Free PMC Article
  3. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The function of the Arabidopsis genes encoding FAB1B and FAB1D, both highly expressed in pollen, were investigated.
    Title: Characterization of FAB1 phosphatidylinositol kinases in Arabidopsis pollen tube growth and fertilization.
  2. Data indicate that single and double mutants of phosphatidylinositol 3-phosphate 5-kinases (PI3P5Ks) FAB1A, FAB1B, FAB1C and FAB1D exhibited slow stomatal closure upon ABA treatment.
    Title: Rapid structural changes and acidification of guard cell vacuoles during stomatal closure require phosphatidylinositol 3,5-bisphosphate.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

NM_001333092.1
NM_001333094.1
NM_103148.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-phosphate 5-kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phosphatidylinositol metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
FORMS APLOID AND BINUCLEATE CELLS 1A
NP_001319143.1
  • FORMS APLOID AND BINUCLEATE CELLS 1A (FAB1D); FUNCTIONS IN: 1-phosphatidylinositol-4-phosphate 5-kinase activity, phosphatidylinositol phosphate kinase activity, ATP binding; INVOLVED IN: phosphatidylinositol metabolic process, cellular protein metabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Chaperonin Cpn60/TCP-1 (InterPro:IPR002423), Phosphatidylinositol-4-phosphate 5-kinase, core (InterPro:IPR002498); BEST Arabidopsis thaliana protein match is: FORMS APLOID AND BINUCLEATE CELLS 1C (TAIR:AT1G71010.1); Has 3115 Blast hits to 2757 proteins in 368 species: Archae - 419; Bacteria - 0; Metazoa - 983; Fungi - 610; Plants - 538; Viruses - 0; Other Eukaryotes - 565 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    12485318..12492207
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001333093.1 → NP_001321920.1  FORMS APLOID AND BINUCLEATE CELLS 1A [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XID0
    UniProtKB/TrEMBL
    A0A178WIJ4
    Conserved Domains (2) summary
    cd03334
    Location:161 → 429
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd17300
    Location:1180 → 1443
    PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins

  2. NM_001333092.1 → NP_001319143.1  FORMS APLOID AND BINUCLEATE CELLS 1A [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XID0
    UniProtKB/TrEMBL
    A0A178WIJ4
    Conserved Domains (2) summary
    cd03334
    Location:161 → 429
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd17300
    Location:1180 → 1443
    PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins

  3. NM_103148.4 → NP_174686.1  FORMS APLOID AND BINUCLEATE CELLS 1A [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_174686.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XID0
    UniProtKB/TrEMBL
    A0A178WIJ4
    Conserved Domains (2) summary
    cd03334
    Location:161 → 429
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd17300
    Location:1180 → 1443
    PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins

  4. NM_001333094.1 → NP_001321919.1  FORMS APLOID AND BINUCLEATE CELLS 1A [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WIJ4, A0A1P8ASD3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XID0.1

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